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U.S. Highway 178 is a spur of U.S. Highway 78. It currently runs for 237 miles (381 km) from Dorchester, South Carolina at U.S. Highway 78 to Rosman, North Carolina at U.S. Highway 64. It passes through the states of South Carolina and North Carolina. It goes through the cities of Pickens, Anderson, Orangeburg, and Bowman, South Carolina.
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Inside the town limits of Rosman, North Carolina, U.S. 178 is called Pickens Highway, referring to Pickens, South Carolina. Once U.S. 178 crosses the North Carolina state line into South Carolina, road signs frequently refer to the road as Moorefield Memorial Highway, commemorating a former South Carolina highway engineer of that name. Inside the city limits of Pickens, South Carolina, U.S. 178 is called Pendleton Street.
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