Lomachenko won gold at the 2008 Olympic Games in Beijing, China. He avenged his 2007 World Championship defeat to Selimov in the first round. Lomachenko beat his five opponents by an astonishing 58-13 on the way to his first gold medal, and was subsequently named the outstanding boxer for the tournament and awarded the Val Barker Trophy.
After winning the gold medal, Lomachenko made the decision to turn pro. After meeting with several fight promoters, Lomachenko signed a contract to fight for Top Rank. Lomachenko made his professional debut in United States 12 October 2013 as part of the undercard to the Timothy Bradley vs. Juan Manuel Marquez main event defeating Mexican fighter Jose Ramirez with a fourth round knockout.