Osmosis Jones

Osmosis Jones
Theatrical poster for Osmosis Jones
Directed by	Bobby Farrelly Peter Farrelly Tom Sito Piet Kroon music= Randy Edelman
Written by	Marc Hyman
Produced by	Dennis Edwards Bobby Farrelly Peter Farrelly Zak Penn Bradley Thomas
Starring	Bill Murray Chris Rock Laurence Fishburne David Hyde Pierce Brandy Norwood William Shatner Molly Shannon
Production company	Warner Bros. Animation
Distributed by	Warner Bros. Pictures
Release date	August 10 2001
Running time	95 min.
Language	English
Budget	$75 million

Osmosis Jones (also known as Ozzy & Drix: The Fantastic Voyage Adventures of Osmosis Jones) (2001) is a live-action/animated film whose title character is Osmosis Jones, an anthropomorphic white blood cell. Unusual for this genre, the live action characters and cartoon characters never meet. The live action characters are people as they appear in the real world, and the animated characters are the cells and germs which live inside a man named Frank, whom the story concerns. It spawned a Saturday morning cartoon spinoff, Ozzy & Drix, which aired on Kids WB from 2002 to 2004, and featured Osmosis Jones and his friend Drix inside a new body.

Plot

Frank is a slovenly zookeeper. Much to the frustration of his young daughter Shane, he eats and drinks compulsively and has no regard for germs or diseases. In the opening scene, Frank consumes a hard-boiled egg that he recovers from the filth and straw of the chimpanzees' enclosure, where it landed after a chimp stole the egg from his hand and Frank pried it from the ape's mouth. Here, Frank cites the "ten second rule" as justification for the unsanitary act.

Inside Frank's body, the story unfolds. Protagonist Osmosis Jones, a former agent of Immunity (Frank's immune system), is a hot-tempered, adventure-seeking white blood cell. He is a rebel cop, frequently disobeying what an authority tells him to do. At the beginning of the story, he is relocated to the mouth to fight against germs entering the body via ingestion following an incident during which he induced Frank to vomit all over Shane's teacher, which was considered a false alarm because he had been the only one to suspect an incoming pathological threat. After several newcomer Germs, believed to be gingivitis, hijack a "squad car" in the mouth, Osmosis Jones and his senior partner, who is piloting their helicopter, are pulled into the lungs by a massive yawn while in pursuit. Even after the germs evade capture and pass into "Immunity's" jurisdiction, Osmosis disobeys direct orders and continues the pursuit on foot. The criminals escape and Osmosis accidentally triggers a major cramp in Frank's leg.

Meanwhile, Mayor Phlegmming is preparing for re-election, campaigning with the promise of more junk food (much to the joy of the citizens in the Love Handle District). The Mayor's reckless policies are largely responsible for Frank's deteriorating health; but his re-election hopes are complicated by the arrival of Thrax, a deadly virus that came with the hard-boiled egg. In an attempt to cover up the severity of the situation, Phlegmming 'tells' Frank to take a cold-suppressant pill. The pill, nicknamed Drix (short for his brand name Drixenol), arrives in the body and covers Frank's infected throat with a disinfectant to cover the irritation. Osmosis Jones is assigned as Drix's partner, much to his chagrin. Eventually, they reveal Thrax's plot to masquerade as the common cold while at the same time plotting to overheat Frank's body, killing him from the inside. Thrax is motivated by a desire to become the nastiest new virus, attempting to kill each new victim faster than the previous. His grandiose plan for Frank is death within 48 hours, breaking all previous medical records.

Osmosis and Drix confront Thrax in one of Frank's zits, where Drix launches a grenade of medication at Thrax and his cronies, popping the skin blemish, and seemingly ending Thrax's siege. To hide the truth, Phlegmming forces Drix to leave the body and fires Osmosis; both protagonists having insisted that Thrax was more than the common cold.

The heroic duo's prediction rings true when Thrax survives the explosion and decides to launch a lone assault on Frank's hypothalamus by disabling its self-regulative capabilities. Soon after does so, Leah Estrogen, the mayor's secretary and Ozzy's love interest throughout the movie, discovers his work (the temperature having risen to 100.735 and alerts security. Thrax manages to evade them; taking Leah hostage, he escapes from the brain to the mouth.

Frank is taken to the hospital under the influence of Thrax's attack. Ozzy rescues Leah and fights Thrax directly, when Thrax leaves Frank's mouth after causing a confultion using pollen. Ozzy is launched out after him by Drix (who has returned to the body and used his standard dosage to temporarily freeze Thrax's chief weapon). During this time Frank goes into cardiac arrest. Thrax and Ozzy arrive on one of Shane's false eyelashes, which she was wearing atop her natural ones. During the struggle, Thrax threatens to kill Shane, but Ozzy causes him to knock Shane's false eyelash into a vessel of alcohol below, so that he is dissolved. Just as doctors give up attempting to revive Frank, he is revived when Ozzy returns the missing hypothalamus chromosone. Ozzy is reinstated into "Immunity" with full privleges, he and Drix (whom he has decided to take as his partner) are declared heroes, and Ozzy finally wins Leah's affection.

The end of the movie shows Frank and Shane on a hike. Frank, having survived Thrax's attack, has begun to improve his diet and personal hygiene. Phlegmming has lost his position as mayor and now is assigned to cleaning the bowels. He ejects himself from the body via the rectum by touching a button marked "DO NOT TOUCH!".

Interlaced with the main plot are several live action sequences that detail Frank's troublesome relationship with Shane. Her mother died at an early age; viewers may speculate that Frank has deteriorated as a result of depression caused by emotional loss, although there is reason to suspect that his wife also led an unhealthy lifestyle which may have caused her death, as suggested during a conversation between Frank and Shane. Frank had humiliated Shane previously by vomiting on her teacher, Mrs. Boyd, during a science fair, in which he ate another student's oyster experiment; Ozzy, patrolling the stomach at the time, saw a nasty germ that had come along with the swallowed oysters and pressed the "puke" button, spraying Mrs. Boyd with bile. The event was put on the front page of the local news, making Ozzy the town laughingstock. This event was responsible for Osmosis Jones' being transferred to duty in the mouth as a punitive measure to keep him from causing any further trouble.

Osmosis Jones' suspicions have frequently been dismissed by others, though ironically he is usually correct even when he lacks the tact or caution to take care of problems without making a mess. This is evidenced by Thrax: "They’re making this too easy. You know, in all the bodies I’ve been in, no one has ever gotten wise to me, and now for the first time an immunity cell has figured out everything, and they don’t believe him!" .

Frank attempted to mend matters, but failed. Throughout the film, Shane is ashamed of her father and attempts to reform him. Seeing him facing a terminal virus prompts an epiphany in both of them, with the result that Frank begins caring for his body, and Shane develops a sense of daughterly pride in her father.

Characters

Live action characters/cities

• Frank (Downtown Frank/The City of Frank) (Bill Murray) is a 40-year-old man prone to eat junk food, discount healthcare of himself, and behave laconically.

• Shane (Elena Franklin) is Frank’s 10-year-old daughter. Due to her father’s shortcomings, health is very important to her. She has become somewhat depressed after her mother’s death, and as a result her grades and relationships with other people are suffering. She is Thrax's second intended victim until his death.

• Mrs. Boyd (Molly Shannon) is Shane’s science and P.E. teacher in school. Having had her reputation and those of her three children ruined after her embarrassment by Frank, she has a 200-yard restraining order against him to prevent any further embarrassment.

• Bob (Chris Elliott) is Frank’s brother and coworker, who, when Frank lost a job at a pea soup factory, got him a job at the zoo. Bob is also the person to which Frank trusted Shane's future when Frank was becoming feverish from his illness.

Animated characters

• Osmosis "Ozzy" Jones (voice of Chris Rock) The Protagonist. An over-zealous white blood cell, specifically a natural killer cell. Osmosis' positive reputation was destroyed when he saw a salmonella pathogen about to enter Frank through a recently ingested raw oyster and reacted by causing him to vomit onto Mrs. Boyd. Since this discrediting incident, he has been placed in out-of-the-way patrols. Therefore he seizes any opportunity to be able to make a difference. It is because of this that he is not believed about Thrax’s infection. Being a cell, Ozzy is able to contort his body drastically, to ooze under doors, and to combine his eyes into one, which allows him to escape Thrax's fate at the film's climax. Few other cells, though presumably able to do likewise, are shown doing so. It was shown in one scene that if enough force is exerted then his morphing will go back to normal as when Ozzy disguised himself as a germ to learn about Thrax's plan, his cover was blown when Thrax's henchman Lard affectionately but roughly patted Ozzy on the back contorting his body back to normal.

• Thrax (voice of Laurence Fishburne) The Antagonist. A tall, extremely virulent, and unusually powerful virus. He claims loudly: “Ebola is a case of dandruff compared to me!”. He is red-skinned and angular in design. He carries a chain consisting of numerous chromosomes removed from other victims. His left index finger is a long claw, which can melt the cellular equivalent of steel, consume cells and other viruses in flames, and alter the properties of other cells. His claw can even melt synthetic polyester fiber (though at a much slower rate), a feature that comes into play at the climax. He appears to be resistant to heat and can glide using his trench coat. Thrax is suave and enjoys jazz. He is known as the Red Death, a reference to Edgar Allan Poe's "The Masque of the Red Death". His name is a play on the word Anthrax. After taking a look at Frank's memory he comically quips "this guy was sick before I even got here". It is likely that he is a fictional virus, but could be meningitis. Thrax is killed at the film's climax when he falls into a tub of rubbing alcohol.

• Drix (voice of David Hyde Pierce) is a cold pill; he is red and yellow, boxy, and robotic. His right arm is a cannon used to shoot an assorted variety of medication, including one that freezes any target. He is a follower of written rules and compensates for his doubts of himself by acting haughtily. He is learned, but not clever. Drix disagrees with Osmosis’s methods, but respects Osmosis for continuing to fight illness despite the lack of faith in him.

• Leah Estrogen (voice of Brandy Norwood) is Mayor Phlegmming’s assistant, greatly relied upon by the Mayor for her skills. She is one of few inhabitants of Frank who realize the flaws of the current administration, and one of the few willing to believe Osmosis’s claims of a large-scale infection. She is Osmosis's love interest, but resists his advances until the end of the film.

• Mayor Phlegmming (voice of William Shatner). Is the short, overweight mayor of the "City of Frank" and is the film's secondary antagonist. He is either the cause or a reflection of Frank’s negligence, and is constantly preoccupied with everything but his job, except when it concerns planning his re-election. He can be considered an anti-hero for his support of an unhealthy Frank. Even in the midst of disaster, his concern is more with his own convenience than anything else, which was revealed by Leah towards the climax of Frank. At the film's climax, when the city of Frank is burning down due to his negligence, Phlegmming is shown having realizes his mistakes and sheds a tear. In a deleted scene, he willingly resigns and is placed in the bowels. His name is a pun on the word phlegm, which he creates inside Frank.

• Tom Colonic (voice of Ron Howard) is Mayor Phlegmming’s opposition in the election. He is a tall, thin cell, and supports a healthier Frank. His mannerisms and personality resemble John F. Kennedy's. He may have become the new mayor after Mayor Phlegmming was sacked.

• The Chief of Police (voice of Joel Silver) is an extremely large, somewhat gelatinous cell with a short temper. He is evidently used to (though frustrated by) Ozzy’s adventures. Ultimately, he becomes supportive of Osmosis when severe symptoms appear.

• Other Germs: In addition to Thrax there are several other germs in Frank's body, most of whom become Thrax's henchmen. This is achieved after Thrax kills the Crime Don of Frank's body (voice of Rodger Bumpass) by impaling him and then slicing him in half with his index finger claw. Although several other germs are in his employ, the only recurring germs are three thugs from the Don's mafia. Cyclops (voice of Eddie Barth) has only one eye; Spider Legs (voice of Carlos Alazraqui) has spider-like legs that give his lower body the appearance of a swivel chair; and Lard is mute and is very fat. Throughout the film they are shown aiding Thrax until their deaths. Lard is killed in the explosion of the Zit, while only Thrax, Cyclops, and Spider Legs survive. Later, in Frank's ingrown toe, Spider Legs and Cyclops try to convince Thrax to hide until they are greater in numbers. Thrax denies this, kills them both, and nonchalantly walks away remarking, "Medical books aren't written about losers!", indicating his determination to continue attacking Frank.

Film production and box office reception

Osmosis Jones went through a troubled time in production. The animated sequences, directed by Tom Sito and Piet Kroon, went into production as planned, but acquiring both a director and a star actor for the live-action sequences took some time, until Bill Murray was cast as the main character of Frank, and Peter and Bobby Farrelly stepped in to direct the live action sequences. As part of their contract, the Farrelly Brothers are credited as the primary directors of the film, although they did no supervision of the animated portions of the film.

Upon its original release, the film lost a considerable amount of money, and was the second-to-last production for Warner Bros.' feature traditional animation department (following The Iron Giant, and followed by Looney Tunes: Back in Action, which both also lost money upon their original releases). Osmosis Jones was not a huge box-office success and received mixed reviews.

Footage cut from the final film

• In the original script and in early cuts of the movie, a scene was featured when Osmosis and Drix go to the Gonad's Gym. It involved their talking to the "exercising" sperm cells. The scene was cut in order to get a PG rating and appeal to a family audience. The Gonad's Gym logo does appear on Drix's suitcase during a scene in police station locker room.
• In an earlier "cut" of the film, Ozzy and Drix visit an amusement park behind Frank's eye, called "See World". A sign advertising the latter can still be seen near Frank's stomach, which functions as the "arrivals" terminal of an airport.
• The DVD release contains three extended (and half-animated) scenes, all of which appear in cut-down form in the final edit:

Drix and Jones visit the eyes, while Drix complains that he has to visit the nose and the throat. Jones gets doughnuts and calls the information desk on his cell phone while at the eyes.

Frank picks his nose during the dam-bursting sequence, and Jones saves Drix from ending up on Frank's fingertip. In the end, they are inhaled into the sinuses.

The race to catch Thrax on his way to the uvula is extended; we see Thrax leap from his car and glide away. After Jones takes the wrong turn, he takes a "shortcut" to the uvula by way of the esophagus, riding a massive, acidic belch up the throat (A reference to the 1991 classic Thelma & Louise). Osmosis says "What the hell is a uvula?" It was later edited from hell to heck.

• A draft of the script reveals that Osmosis, as a young boy, went to a family reunion. At that time Frank went to the doctors to have some blood removed. The needle drew out all of Ozzy's relatives, apparently leaving him all alone. The ending has Frank getting a blood transfusion to save his life, with his own prior blood. Thus Ozzy's family and relatives would have returned to Frank, in a parody of the abductees returning in Close Encounters of the Third Kind. This was detailed in the film's commentary.
• Another scene that was cancelled so as to cut time was a scene where it showed how Phlegmming got kicked out of office. In the final cut it's assumed that he was impeached but in a deleted scene he realizes all of his mistakes and willingly resigns thus putting Tom Colonic in office. This explains how he lost office at the film's end. This was supposed to connect with a scene when Phelgmming sees the city going up in flames and sheds a tear upon realizing all that he has done has caused Frank's near-destruction (this scene being left in the final cut).

Pop Culture References

• In the film Titanic during Frank's near death experience, the leader of a group of street performers remarks, "Gentlemen, playing with you has been my greatest pleasure of my life," before playing one final stanza. As they play their requiem tune symbolizing the apparent end of Frank. In the film Titanic the ships orchestral quartet does the same (as it has been rumored happened on the actual Titanic). Mayor Phlegmming's scene of shedding a tear at realizing how he's doomed everyone in Frank also parallels Titanic's captain Edward Smith and Titanic's builder Thomas Andrews Jr. both of whom went down with the ship.
• The Matrix is parodied briefly during the final fight between Jones and Thrax (Matrix star Laurence Fishbourne) on the surface of Shane's eyeball. As Thrax gives Jones a roundhouse kick and Jones bends down to duck, the scene freezes and the camera swivels around the two in trademark Matrix style.
• In the scene where Jones stops Drix from leaving Frank, one of the germs is holding a Pikachu.

Merchandising

There was very little merchandising for the film. Trendmasters planned on releasing a toy line of the characters from the film (including but not limited to action figures, "flingable snot" and the like). However, they claimed they would only release the toys if the film exceeded $65 million at the box office. Unfortunately, the film failed to do so and the toys were never released. One of a few products released was a video game based on the series Ozzy & Drix. Hats, posters, soundtracks and presskits for the film can be found on eBay.

Soundtrack

1. "Summer In the City" - St. Lunatics
2. "Big Ball" - Drama
3. "Solo Star" - Solange Knowles
4. "Open" - Brandy
5. "Fill Me In (Part 2)" - Craig David
6. "I Believe" - R. Kelly
7. "Cool, Daddy Cool" - Kid Rock
8. "Turn It Out" - De La Soul
9. "Take It To Da House" - Trick Daddy
10. "Just In Case" - Nivea
11. "Why Did You Have To Be" - Debelah Morgan
12. "Don't Be Mad" - Sunshine Anderson
13. "Here We Go Again" - Nappy Roots
14. "Love Me Or Leave Me" - Ms. Toi
15. "Rider Like Me" - Ezekiel Lewis
16. "Break U Off" - Uncle Kracker

Hidden Tracks Only In Certain Albums.

1. "Work"-Britney Spears
2. "Body"-Brandy Norwood

Cast and crew

Directors

• Tom Sito and Piet Kroon
• Peter Farrelly and Bobby Farrelly (live action)

Voice cast

• Chris Rock - Osmosis Jones
• Laurence Fishburne - Thrax
• David Hyde Pierce - Drix
• Brandy Norwood - Leah
• William Shatner - Mayor Flemming
• Ron Howard - Tom Colonic

In addition, Ben Stein, Joel Silver, John Melendez and Kid Rock's band (including himself, Joe C., and Uncle Kracker) have cameo voice roles.

Live action cast

• Bill Murray - Frank Detomello
• Elena Franklin - Shane Detomello
• Chris Elliott - Bob Detomello
• Molly Shannon - Mrs. Boyd

External links

• Official site
• Osmosis Jones at IMDb