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Revision as of 21:02, 6 March 2011
Template:PBB Nuclear receptor-interacting protein 1 is a protein that in humans is encoded by the NRIP1 gene.[1][2]
RIP140 has an important role in regulating lipid and glucose metabolism. [3], and regulates gene expression in metabolic tissues including heart [4], skeletal muscle [5], liver [6] and adipose [7]
Knockout mice that completely lack the RIP140 molecule are lean and stay lean, even on a rich diet.[8] RIP140 is part of the chain by which tumors can cause cachexia.[9][10]
A major role for RIP140 in adipose tissue is to block the expression of genes involved in energy dissipation and mitochondrial uncoupling, including uncoupling protein 1 and carnitine palmitoyltransferase 1b.[11]
Knockout mice (females) are also infertile because they fail to ovulate.[12]
Interactions
NRIP1 has been shown to interact with Retinoic acid receptor alpha,[13][14][15] YWHAQ,[16] Glucocorticoid receptor,[17][16][18] Histone deacetylase 5,[19] CTBP2,[20][19] Estrogen receptor alpha,[1][21][15] Aryl hydrocarbon receptor,[22] Steroidogenic factor 1,[23][24] DAX1,[24] CTBP1[19][25] and Retinoid X receptor alpha.[14][15]
See also
External links
- NRIP1 protein, human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- NURSA C258
References
- ^ a b Cavailles V, Dauvois S, L'Horset F, Lopez G, Hoare S, Kushner PJ, Parker MG (1995). "Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor". EMBO J. 14 (15): 3741–51. PMC 394449. PMID 7641693.
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ignored (help)CS1 maint: multiple names: authors list (link) Cite error: The named reference "pmid7641693" was defined multiple times with different content (see the help page). - ^ Katsanis N, Ives JH, Groet J, Nizetic D, Fisher EM (1998). "Localisation of receptor interacting protein 140 (RIP140) within 100 kb of D21S13 on 21q11, a gene-poor region of the human genome". Hum Genet. 102 (2): 221–3. doi:10.1007/s004390050682. PMID 9521594.
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ignored (help)CS1 maint: multiple names: authors list (link) - ^ Rosell M, Jones MC, Parker MG (2010). "Role of nuclear receptor corepressor RIP140 in metabolic syndrome". Biochim Biophys Acta. doi:10.1016/j.bbadis.2010.12.106. PMID 21193034.
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(help)CS1 maint: multiple names: authors list (link) - ^ Fritah A, Steel JH, Nichol D, Parker N, Williams S, Price A, Strauss L, Ryder TA, Mobberley MA, Poutanen M, Parker M, White R (2010). "Elevated expression of the metabolic regulator receptor-interacting protein 140 results in cardiac hypertrophy and impaired cardiac function". Cardiovasc Res. 86 (3): 443–451. PMID 20083575.
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(help); Text "doi: 10.1093/cvr/cvp418" ignored (help)CS1 maint: multiple names: authors list (link) - ^ Seth A, Steel JH, Nichol D, Pocock V, Kumaran MK, Fritah A, Mobberley M, Ryder TA, Rowlerson A, Scott J, Poutanen M, White R, Parker M. (2007). "The transcriptional corepressor RIP140 regulates oxidative metabolism in skeletal muscle". Cell Metab. 6 (3): 236–245. doi:10.1016/j.cmet.2007.08.004. PMID 17767910.
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ignored (help)CS1 maint: multiple names: authors list (link) - ^ Herzog B, Hallberg M, Seth A, Woods A, White R, Parker MG. (2007). "The nuclear receptor cofactor, receptor-interacting protein 140, is required for the regulation of hepatic lipid and glucose metabolism by liver X receptor". Mol Endocrionol. 21 (11): 2687–97. doi:10.1210/me.2007-1213. PMID 17684114.
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ignored (help)CS1 maint: multiple names: authors list (link) - ^ Rosell M, Jones MC, Parker MG (2010). "Role of nuclear receptor corepressor RIP140 in metabolic syndrome". Biochim Biophys Acta. doi:10.1016/j.bbadis.2010.12.106. PMID 21193034.
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(help)CS1 maint: multiple names: authors list (link) - ^ Leonardsson G, Steel JH, Christian M, Pocock V, Milligan S, Bell J, So PW, Medina-Gomez G, Vidal-Puig A, White R, Parker MG (2004). "Nuclear receptor corepressor RIP140 regulates fat accumulation". Proc Natl Acad Sci U S A. 101 (22): 8437–42. doi:10.1073/pnas.0401013101. PMID 15155905.
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ignored (help)CS1 maint: multiple names: authors list (link) - ^ "A common denominator of inflammations and fatty liver". News. Science Centric. 2008-05-31. Retrieved 2008-08-31.
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(help) [dead link] - ^ Diaz MB, Krones-Herzig A, Metzger D, Ziegler A, Vegiopoulos A, Klingenspor M, Müller-Decker K, Herzig S (2008). "Nuclear receptor cofactor receptor interacting protein 140 controls hepatic triglyceride metabolism during wasting in mice". Hepatology. 48 (3): 782–791. doi:10.1002/hep.22383. PMID 18712775.
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ignored (help)CS1 maint: multiple names: authors list (link) - ^ Debevec D, Christian M, Morganstein D, Seth A, Herzog B, Parker M, White R (2007). "Receptor interacting protein 140 regulates expression of uncoupling protein 1 in adipocytes through specific peroxisome proliferator activated receptor isoforms and estrogen-related receptor alpha". Mol. Endocrinol. 21 (7): 1581–92. doi:10.1210/me.2007-0103. PMC 2072047. PMID 17456798.
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ignored (help)CS1 maint: multiple names: authors list (link) - ^ White R, Leonardsson G, Rosewell I, Ann Jacobs M, Milligan S, Parker M. (2000). "The nuclear receptor co-repressor nrip1 (RIP140) is essential for female fertility". Nat. Med. 6 (12): 1368–74. PMID 11100122.
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: Text "doi 10.1038/82183" ignored (help)CS1 maint: multiple names: authors list (link) - ^ Hu, Xinli (2004). "Suppressive effect of receptor-interacting protein 140 on coregulator binding to retinoic acid receptor complexes, histone-modifying enzyme activity, and gene activation". J. Biol. Chem. 279 (1). United States: 319–25. doi:10.1074/jbc.M307621200. ISSN 0021-9258. PMID 14581481.
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ignored (help)CS1 maint: year (link) - ^ Tazawa, Hiroshi (2003). "Regulation of subnuclear localization is associated with a mechanism for nuclear receptor corepression by RIP140". Mol. Cell. Biol. 23 (12). United States: 4187–98. doi:10.1128/MCB.23.12.4187-4198.2003. ISSN 0270-7306. PMC 156128. PMID 12773562.
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ignored (help)CS1 maint: year (link) - ^ Subramaniam, N (1999). "Receptor interacting protein RIP140 inhibits both positive and negative gene regulation by glucocorticoids". J. Biol. Chem. 274 (25). UNITED STATES: 18121–7. doi:10.1074/jbc.274.25.18121. ISSN 0021-9258. PMID 10364267.
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Further reading
This article incorporates text from the United States National Library of Medicine, which is in the public domain.