User talk:Pharmstd2018

November 2018

Hello, I'm CAPTAIN RAJU. I wanted to let you know that one or more of your recent contributions to Ibuprofen have been undone because they did not appear constructive. If you would like to experiment, please use the sandbox. If you have any questions, you can ask for assistance at the Help Desk. CAPTAIN RAJU^(T) 20:46, 4 November 2018 (UTC)

Welcome

Welcome to Wikipedia and Wikiproject Medicine

Welcome to Wikipedia! We have compiled some guidance for new healthcare editors:

1. Please keep the mission of Wikipedia in mind. We provide the public with accepted knowledge, working in a community.
2. We do that by finding high quality secondary sources and summarizing what they say, giving WP:WEIGHT as they do. Please do not try to build content by synthesizing content based on primary sources.
3. Please use high-quality, recent, secondary sources for medical content (see WP:MEDRS; for the difference between primary and secondary sources, see the WP:MEDDEF section.) High-quality sources include review articles (which are not the same as peer-reviewed), position statements from nationally and internationally recognized bodies (like CDC, WHO, FDA), and major medical textbooks. Lower-quality sources are typically removed. Please beware of predatory publishers – check the publishers of articles (especially open source articles) at Beall's list.
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5. We don't use terms like "currently", "recently," "now", or "today". See WP:RELTIME.
6. More generally see WP:MEDHOW, which gives great tips for editing about health -- for example, it provides a way to format citations quickly and easily
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Once again, welcome, and thank you for joining us! Please share these guidelines with other new editors.

– the WikiProject Medicine team Jytdog (talk) 16:42, 5 November 2018 (UTC)

November 2018

Please stop adding unsourced content, as you did on Aripiprazole. This violates Wikipedia's policy on verifiability. If you continue to do so, you may be blocked from editing Wikipedia. ~ GB fan 16:43, 5 November 2018 (UTC)

Please stop adding unsourced content, as you did on Cannabidiol. This violates Wikipedia's policy on verifiability. If you continue to do so, you may be blocked from editing Wikipedia. Zefr (talk) 18:27, 5 November 2018 (UTC)

Your recent editing history at Cannabidiol shows that you are currently engaged in an edit war. To resolve the content dispute, please do not revert or change the edits of others when you are reverted. Instead of reverting, please use the talk page to work toward making a version that represents consensus among editors. The best practice at this stage is to discuss, not edit-war. See BRD for how this is done. If discussions reach an impasse, you can then post a request for help at a relevant noticeboard or seek dispute resolution. In some cases, you may wish to request temporary page protection.

Being involved in an edit war can result in your being blocked from editing—especially if you violate the three-revert rule, which states that an editor must not perform more than three reverts on a single page within a 24-hour period. Undoing another editor's work—whether in whole or in part, whether involving the same or different material each time—counts as a revert. Also keep in mind that while violating the three-revert rule often leads to a block, you can still be blocked for edit warring—even if you don't violate the three-revert rule—should your behavior indicate that you intend to continue reverting repeatedly. Zefr (talk) 18:35, 5 November 2018 (UTC)

References

Just follow the steps 1, 2 and 3 as shown and fill in the details

Thank you for contributing to Wikipedia. Remember that when adding content about health, please only use high-quality reliable sources as references. We typically use review articles, major textbooks and position statements of national or international organizations (There are several kinds of sources that discuss health: here is how the community classifies them and uses them). WP:MEDHOW walks you through editing step by step. A list of resources to help edit health content can be found here. The edit box has a built-in citation tool to easily format references based on the PMID or ISBN.

1. While editing any article or a wikipage, on the top of the edit window you will see a toolbar which says "cite" click on it
2. Then click on "templates",
3. Choose the most appropriate template and fill in the details beside a magnifying glass followed by clicking said button,

We also provide style advice about the structure and content of medicine-related encyclopedia articles. The welcome page is another good place to learn about editing the encyclopedia. If you have any questions, please feel free to drop me a note. Doc James (talk · contribs · email) 20:04, 5 November 2018 (UTC)

November 2018

Please do not add or change content, as you did at Donepezil, without citing a reliable source. Please review the guidelines at Wikipedia:Citing sources and take this opportunity to add references to the article. Thank you. Natureium (talk) 21:30, 5 November 2018 (UTC)

Hi Pharmstd2018! I've noticed you've been adding information to a lot of pharmaceutical articles without a proper source. For any kind of biomedical information, we have to include WP:MEDRS sources. Your additions are helpful, but we can't keep them if we don't have the source attached. I see that someone added some information on this a little higher up on your talk page. I suggest you read this, because I do appreciate your edits and don't want al of your work to have to be undone. Natureium (talk) 13:26, 6 November 2018 (UTC)

Wikipedia and copyright

Hello Pharmstd2018, and welcome to Wikipedia. All or some of your addition(s) to Amoxicillin/clavulanic acid have been removed, as they appear to have added copyrighted material without evidence of permission from the copyright holder. While we appreciate your contributions to Wikipedia, there are certain things you must keep in mind about using information from sources to avoid copyright and plagiarism issues here.

• You can only copy/translate a small amount of a source, and you must mark what you take as a direct quotation with double quotation marks (") and cite the source using an inline citation. You can read about this at Wikipedia:Non-free content in the sections on "text". See also Help:Referencing for beginners, for how to cite sources here.
• Aside from limited quotation, you must put all information in your own words and structure, in proper paraphrase. Following the source's words too closely can create copyright problems, so it is not permitted here; see Wikipedia:Close paraphrasing. (There is a college-level introduction to paraphrase, with examples, hosted by the Online Writing Lab of Purdue.) Even when using your own words, you are still, however, asked to cite your sources to verify the information and to demonstrate that the content is not original research.
• Our primary policy on using copyrighted content is Wikipedia:Copyrights. You may also want to review Wikipedia:Copy-paste.
• If you own the copyright to the source you want to copy or are a legally designated agent, you may be able to license that text so that we can publish it here. Understand, though, that unlike many other sites, where a person can license their content for use there and retain non-free ownership, that is not possible at Wikipedia. Rather, the release of content must be irrevocable, to the world, into the public domain (PD) or under a suitably-free and compatible copyright license. Such a release must be done in a verifiable manner, so that the authority of the person purporting to release the copyright is evidenced. See Wikipedia:Donating copyrighted materials.
• In very rare cases (that is, for sources that are PD or compatibly licensed) it may be possible to include greater portions of a source text. However, please seek help at Wikipedia:Media copyright questions, the help desk or the Teahouse before adding such content to the article. 99.9% of sources may not be added in this way, so it is necessary to seek confirmation first. If you do confirm that a source is public domain or compatibly licensed, you will still need to provide full attribution; see Wikipedia:Plagiarism for the steps you need to follow.
• Also note that Wikipedia articles may not be copied or translated without attribution. If you want to copy or translate from another Wikipedia project or article, you must follow the copyright attribution steps in Wikipedia:Translation#How to translate. See also Wikipedia:Copying within Wikipedia.

It's very important that contributors understand and follow these practices, as policy requires that people who persistently do not must be blocked from editing. If you have any questions about this, you are welcome to leave me a message on my talk page. Thank you. Natureium (talk) 13:28, 6 November 2018 (UTC)

Copied?

Where is the stuff that you just posted on your userpage from? It appears to be copy/pasted from somewhere. Jytdog (talk) 23:46, 24 November 2018 (UTC)

Speedy deletion nomination of Xanthine oxidase inhibitor from natural sources

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A tag has been placed on Xanthine oxidase inhibitor from natural sources requesting that it be speedily deleted from Wikipedia. This has been done under section G12 of the criteria for speedy deletion, because the page appears to be an unambiguous copyright infringement. This page appears to be a direct copy from https://www.researchgate.net/publication/272182190_Natural_Xanthine_Oxidase_Inhibitors_for_Management_of_Gout_A_Review. For legal reasons, we cannot accept copyrighted text or images taken from other web sites or printed material, and as a consequence, your addition will most likely be deleted. You may use external websites or other printed material as a source of information, but not as a source of sentences. This part is crucial: say it in your own words. Wikipedia takes copyright violations very seriously and persistent violators will be blocked from editing.

If the external website or image belongs to you, and you want to allow Wikipedia to use the text or image — which means allowing other people to use it for any reason — then you must verify that externally by one of the processes explained at Wikipedia:Donating copyrighted materials. The same holds if you are not the owner but have their permission. If you are not the owner and do not have permission, see Wikipedia:Requesting copyright permission for how you may obtain it. You might want to look at Wikipedia's copyright policy for more details, or ask a question here.

If you think this page should not be deleted for this reason, you may contest the nomination by visiting the page and clicking the button labelled "Contest this speedy deletion". This will give you the opportunity to explain why you believe the page should not be deleted. However, be aware that once a page is tagged for speedy deletion, it may be deleted without delay. Please do not remove the speedy deletion tag from the page yourself, but do not hesitate to add information in line with Wikipedia's policies and guidelines. Praxidicae (talk) 21:27, 26 November 2018 (UTC)

Hormone-sensitive lipase inhibitor moved to draftspace

I've moved this article to draft because it is promotional, cites the same author in 5 of the sources, and looks to be copied and pasted from somewhere. Where did this article originally come from? Natureium (talk) 21:38, 26 November 2018 (UTC)

Your submission at Articles for creation: Xanthine oxidase inhibitors from natural sources (November 27)

Your recent article submission to Articles for Creation has been reviewed! Unfortunately, it has not been accepted at this time. The reasons left by Jovanmilic97 were: Please check the submission for any additional comments left by the reviewer. You are encouraged to edit the submission to address the issues raised and resubmit when they have been resolved.

• If you would like to continue working on the submission, go to Draft:Xanthine oxidase inhibitors from natural sources and click on the "Edit" tab at the top of the window.
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• If you need any assistance, you can ask for help at the Articles for creation help desk or on the reviewer's talk page.
• You can also use Wikipedia's real-time chat help from experienced editors.

Jovanmilic97 (talk) 11:26, 27 November 2018 (UTC)

Hello, Pharmstd2018! Having an article declined at Articles for Creation can be disappointing. If you are wondering why your article submission was declined, please post a question at the Articles for creation help desk. If you have any other questions about your editing experience, we'd love to help you at the Teahouse, a friendly space on Wikipedia where experienced editors lend a hand to help new editors like yourself! See you there! Jovanmilic97 (talk) 11:26, 27 November 2018 (UTC)

Image source problem with File:Xanthine oxidase inhibitor.png

Image Copyright problem

Thank you for uploading File:Xanthine oxidase inhibitor.png.

This image is a derivative work, containing an "image within an image". Examples of such images would include a photograph of a sculpture, a scan of a magazine cover, or a screenshot of a computer game or movie. In each of these cases, the rights of the creator of the original image must be considered, as well as those of the creator of the derivative work.

While the description page states who made this derivative work, it currently doesn't specify who created the original work, so the overall copyright status is unclear. If you did not create the original work depicted in this image, you will need to specify the owner of the copyright.

If you have uploaded other derivative works, consider checking that you have specified their source and tagged them, too. You can find a list of files you have created in your upload log. Unsourced and untagged images may be deleted one week after they have been tagged, as described in section F4 of the criteria for speedy deletion. If the image is copyrighted under a non-free license (per Wikipedia:Fair use) then the image will be deleted 48 hours after 16:48, 27 November 2018 (UTC). If the file is already gone, you can still make a request for undeletion and ask for a chance to fix the problem. If you have any questions please ask them at the Media copyright questions page. Thank you. Ronhjones  ^(Talk) 16:48, 27 November 2018 (UTC)

Your contributed article, Xanthine oxidase ihibitors

If this is the first article that you have created, you may want to read the guide to writing your first article.

You may want to consider using the Article Wizard to help you create articles.

Hello, I noticed that you recently created a new page, Xanthine oxidase ihibitors. First, thank you for your contribution; Wikipedia relies solely on the efforts of volunteers such as you. Unfortunately, the page you created covers a topic on which we already have a page – Xanthine oxidase inhibitor. Because of the duplication, your article has been tagged for speedy deletion. Please note that this is not a comment on you personally and we hope you will continue helping to improve Wikipedia. If the topic of the article you created is one that interests you, then perhaps you would like to help out at Xanthine oxidase inhibitor. If you have new information to add, you might want to discuss it at the article's talk page.

If you think the article you created should remain separate, you may contest the nomination by visiting the page and clicking the button labelled "Contest this speedy deletion". This will give you the opportunity to explain why you believe the page should not be deleted. However, be aware that once a page is tagged for speedy deletion, it may be deleted without delay. Please do not remove the speedy deletion tag from the page yourself, but do not hesitate to add information in line with Wikipedia's policies and guidelines. If the page is deleted, and you wish to retrieve the deleted material for future reference or improvement, then please contact the deleting administrator, or if you have already done so, you can place a request here. Additionally if you would like to have someone review articles you create before they go live so they are not nominated for deletion shortly after you post them, allow me to suggest the article creation process and using our search feature to find related information we already have in the encyclopedia. Try not to be discouraged. Wikipedia looks forward to your future contributions.  GILO   A&E⇑  13:36, 1 December 2018 (UTC)

Your submission at Articles for creation: Xanthine oxidase inhibitors (December 6)

Your recent article submission to Articles for Creation has been reviewed! Unfortunately, it has not been accepted at this time. The reason left by Graeme Bartlett was: Please check the submission for any additional comments left by the reviewer. You are encouraged to edit the submission to address the issues raised and resubmit when they have been resolved.

• If you would like to continue working on the submission, go to Draft:Xanthine oxidase inhibitors and click on the "Edit" tab at the top of the window.
• If you now believe the draft cannot meet Wikipedia's standards or do not wish to progress it further, you may request deletion. Please go to Draft:Xanthine oxidase inhibitors, click on the "Edit" tab at the top of the window, add "{{db-self}}" at the top of the draft text and click the blue "publish changes" button to save this edit.
• If you need any assistance, you can ask for help at the Articles for creation help desk or on the reviewer's talk page.
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Graeme Bartlett (talk) 02:06, 6 December 2018 (UTC)

Your submission at Articles for creation: Xanthine oxidase inhibitors from natural sources (December 6)

Your recent article submission to Articles for Creation has been reviewed! Unfortunately, it has not been accepted at this time. The reason left by HighKing was:  The comment the reviewer left was: Please check the submission for any additional comments left by the reviewer. You are encouraged to edit the submission to address the issues raised and resubmit when they have been resolved.

• If you would like to continue working on the submission, go to Draft:Xanthine oxidase inhibitors from natural sources and click on the "Edit" tab at the top of the window.
• If you now believe the draft cannot meet Wikipedia's standards or do not wish to progress it further, you may request deletion. Please go to Draft:Xanthine oxidase inhibitors from natural sources, click on the "Edit" tab at the top of the window, add "{{db-self}}" at the top of the draft text and click the blue "publish changes" button to save this edit.
• If you need any assistance, you can ask for help at the Articles for creation help desk or on the reviewer's talk page.
• You can also use Wikipedia's real-time chat help from experienced editors.

HighKing⁺⁺ 22:32, 6 December 2018 (UTC)

Pancreatic lipase inhibitors from natural sources

Human pancreatic lipase

Pancreatic lipase, also known as pancreatic triacylglycerol lipase or steapsin is a lipolytic enzyme synthesized and released in the pancreatic juice by the pancreas, plays an essential role in digestion and absorption of triglycerides from the gut It that breaks down fat molecules obtained from diet. It mainly responsible for the hydrolysis of ester linkages of triglycerides in order to convert them to monoglycerides and free fatty acids.(1)

Pancreatic enzymes inhibitors

They are agents that limit diet lipids digestion and fats absorption from intestine (2). The only FDA approved pharmacological agent works as a potent pancreatic lipase inhibitor & one of the best-selling drugs is orlistat (Xenical).(3) Orlistat hydrogenated derivative of lipstatin derived from Streptomyces toxytricini that increases fecal fat excretion in dose dependent manner, thus inhibit approximately 25-30% of calories ingested as fat. It's one of the best-selling drugs over the world for there effectiveness in the treatment of human obesity.(4)(6) Orlistat has unpleasant GI side effects (like oily stools, oily spotting, and flatulence ) that make researchers tend to find more reliable to use agents and here we will discuss there tendencies to find pancreatic lipase inhibitors from natural sources that work locally with less systemic side effects.

Obesity and Pancreatic lipase inhibitors

Obesity is a metabolic disorder, caused by an imbalance between the energy intake and expenditure. Obesity and central obesity are strongly related to increase morbidity and mortality rate, cardiovascular complications (hypertension, HF, Afib, stroke for example), dyslipidemia and type 2 diabetes mellitus. So several pharmacological and non-pharmacological strategies have been implemented to find treatments for this critical problem.(7-9) The elevation in plasma triglycerides is considered the major contributor for the development of obesity and it's complications. Thus, the inhibition of diet lipids absorption is such a rate limiting step in prevention of human obesity and this can occur by the inhibiting of the enzyme responsible for the hydrolysis of diet fat and therefore inhibits there absorption.(10) In this article we will discuss some natural sources tested in vitro for there ability to inhibit pancreatic lipase enzyme that secreted from pancreas.

Medicinal plants with pancreatic lipase inhibitory effect.

plants materials were collected during the flowering phase of these plants.They were cleaned and dried at room temperature then passed through a 24 mesh sieve to create a homogeneous powder which stored at room temperature and protected from light. Methanolic extract were conducted and enzyme preparation were done then pancreatic lipase activity were measured by sperctrophotometric assay through measuring the p-nitrophenol releas.The net result of this process is obtaining IC50 of each plant extract.

Anthemis palaestina Boiss

A.palaestina is one of the most potent plant extracts that shows dose dependent pancreatic lipase inhibitory effect ranging from20-56% with a IC50 about 107mcg/ml. By this result we can consider these plants as a promising agents for the treatment of hypertriglyceridemia and an adjunctive method to treat human obesity. In Addition to anti-PL effect of this plant, it was previously reported that A.plaestina has antioxidant activity.(11) Further studies are needed, using animal models, to verify the inhibitory activities of these plant in-vivo.

Salvia spinosa

S.spinosa belongs to Lamiaceae family and it's also consider potent plants extract that has anti-PL activity ranging from 5-55% in dose dependent manner with a IC50 about 156.2mcg/ml. It's also such a promising materials for the treatment of hypertriglyceridemia and an adjunctive method to treat human obesity. However, Further studies are needed using animal models to verify the inhibitory activities of these plant in-vivo.

Rosemary, Rosmarinus officinalis

Rosemary has been used for a wide range of disease as antispasmodic,anti-inflammatory,antimicrobial,anticarcinogenic,a reliever of respiratory symptoms and a stimulator of hair growth.(12) Rosemary methanolic extracts and pure compounds was recently studied for both hormone sensitive lipase (HSL) and pancreatic lipase (PL).This would provide promising strategy in combating both obesity and hyperglycemia and their complications.(13) Rosemary methanolic extract exhibited a significant inhibitory activity on both enzymes with an IC50 13.8mcg/ml for PL and 95.2mcg/ml for HSL. The rosemary extract was more effective against PL than that of HSL. They also studied the effect of pure compounds {rosmarinic acid (RA), chlorogenic acid (CA), caffeic acid (CaA) and gallic acid (GA)} on PL and HSL and the conclusion of this study is that all tested compounds were able to inhibit both PL and HSL in dose dependent manner with highest potency of GA towards PL and HSL. However, further studies are needed to determine whether these in vitro findings would correlate with the in vivo effects.

Gingko biloba L. (Ginkgoaceae)

G. biloba has been used for medical purposes as dietary supplement or phytomedicine. It has a cardiovascular, neuroprotective and cerebrovascular effects. The plant extract of Ginkgo biloba after investigation showed a fat mass reduction, hypolipidaemic effect, and a potential weight reduction effect. The extract have different types of active compounds, the most important ones are terpene trilactones (TTLs) and flavonol glycosides. These active compounds have antioxidant effects, inhibition of platelet aggregation and thromboxane & fatty acid synthase inhibition activity which is the target for the treatment of obesity. An in vitro study done to evaluate the inhibitory effect of G. biloba against PL, the study was computer-aided molecular docking of TTLs, into the binding pocket of PL in order to reach to conclusions about terpenes/PL-binding energetics. The results were the anti-lipase activity of the methanolic extract of G.biloba leaves revealed a potent PL inhibition activity in a concentration-dependent manner with IC50 = 16.5 μg/mL.(14)

Berberine and Dihydroberberine

Berberine (BBR) is an isoquinoline alkaloid found in Hydrastis canadensis, Berberis and Cortex phellodendri. BBR was found to help diabetes and serum lipid profile by reducing serum cholesterol, triglyc-erides, and LDL-cholesterol. An in vitro study done to evaluate its inhibitory effect by computer-aided molecular docking of BBR and HBBR into the binding pocket of PL. It showed that it has a potential hypolipidemic effects and fat-mass reduction activities.(15)

Willd(candle nut/buah keras), and fruits of Archidendron jiringa

In a study of 98 plants from malaysia by Ado et al. to evaluate the antipancreatic lipase activity of their methanolic exracts the above two plants showed the highest antilipase activity which is 100% and are equivalent to 0.11mcg of orlistat/ml.(16)

Cudrania tricuspidata

In a study of an in-vitro screening for procine pancreatic lipase inhibiton activity using ethanol exracts of each plants,Cudrania tricuspidata showed anti-lipase activity at concentration (50-250mg/kg).In addition,this plant exrtact decrease triglycerol levels at concentration 50mg/kg and delay lipid absorption at higher concentrations.

References

(1)Chapus C, Rovery M, Sarda L, Verger R (1988). "Minireview on pancreatic lipase and colipase". Biochimie. 70 (9): 1223–1234. doi:10.1016/0300-9084(88)90188-5. PMID 3147715.

(2)Klein S. Long-term pharmacotherapy for obesity. Obes. Res. 2004; 12 Suppl:163S-166S.

(3)Lean M. E. J., Campbell P. Orlistat. J. Drug Eval. 2004; 2:179-218

(4)Hauptman J. B., Jeunet F. S., Hartman D. Initial studies in humans with the novel gastrointestinal lipase inhibitor Ro 18-0647 (tetrahydrolipstatin). Am. J. Clin. Nutr. 1992; 55:309S-313S

(5)Drent M. L., Larsson I., William-Olsson T., Quaade F., Czubayko F., von Bergmann K., Strobel W., Sjostrom L., van der Veen E. A. Orlistat (Ro 18-0647), a lipase inhibitor, in the treatment of human obesity: a multiple dose study. Int. J. Obes. Rela.t Metab. Disord. 1995; 19:221-226.

(6)Sjostrom L., Rissanen A., Andersen T., Boldrin M., Golay A., Koppeschaar H. P. F., Krempf M. Randomized placebo-controlled trial of orlistat for weight loss and prevention of weight regain in obese patients. Lancet 1998; 352:167-173.

(7)Cairns E. Obesity: the fat lady sings? Drug Discov. Today 2005; 10:305-307.

(8)Vega G. L. Results of expert meetings: obesity and cardiovascular disease. Obesity, the metabolic syndrome, and cardiovascular disease. Am. Heart J. 2001; 142:1108-1116.

(9)Ioannides-Demos L. L., Proietto J., Tonkin A. M., McNeil J. J. Safety of drug therapies used for weight loss and treatment of obesity. Drug Saf. 2006; 29:277-302.

(10)Verger R. Interfacial activation of lipases: Facts and artifacts. Trends Biotechnol. 1997; 15:32-38.

(11)Tawaha K., Alali F. Q., Gharaibeh M., Mohammad M., El-Elimat T. Antioxidant activity and total phenolic content of selected Jordanian plant species. Food Chem. 2007; 104:1372-1378.

(12)Al-Sereiti MR, Abu-Amer KM, Sen P (1999). Pharmacology of rosemary (Rosmarinus officinalis Linn.) and its therapeutic potentials. Indian J. Exp. Biol., 37: 124-130.

(13)Bassani V, Casadebaig J, Jacob M, Menut C, Lechat I , Lamaty G (1990). Preparation of a low-alcohol extract of Rosmarinus officinalis using a reverse osmosis membrane. Int. J. Pharm., 63: 57-63.

(14) Yasser Bustanji, Ihab M. Al-Masri, Mohammad Mohammad, Mohammad Hudaib, Khaled Tawaha, Hamada Tarazi & Hatim S. AlKhatib (2011) Pancreatic lipase inhibition activity of trilactone terpenes of Ginkgobiloba, Journal of Enzyme Inhibition and Medicinal Chemistry, 26:4, 453-459, DOI: 10.3109/14756366.2010.525509

(15) Al-masri, I., Issa, A., Khdair, A. and Bustanji, Y. (2018). Inhibition of pancreatic lipase by berberine and dihydroberberine: an investigation by docking simulation and experimental validation. [online] Academia.edu. Available at: http://www.academia.edu/19808499/Inhibition_of_pancreatic_lipase_by_berberine_and_dihydroberberine_an_investigation_by_docking_simulation_and_experimental_validation

(16)M. A. Ado, F. Abas, A. S. Mohammed, and H. M. Ghazali, “Anti- and pro-lipase activity of selected medicinal, herbal and aquatic plants, and structure elucidation of an anti-lipase compound,” Molecules, vol. 18, no. 12, pp. 14651–14669, 2013.

(17)Y. S. Kim, Y. Lee, J. Kim et al., “Inhibitory activities of Cudrania tricuspidata leaves on pancreatic lipase in vitro and lipolysis in vivo,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 878365, 8 pages, 2012.