Haplogroup L3
Haplogroup L3 | |
---|---|
Possible time of origin | 60,000–70,000 YBP[1] |
Possible place of origin | Asia or East Africa[1] |
Ancestor | L3'4 |
Descendants | L3a, L3b'f, L3c'd, L3e'i'k'x, L3h, M, N |
Defining mutations | 769, 1018, 16311[2] |
Haplogroup L3 is a human mitochondrial DNA (mtDNA) haplogroup. The clade has played a pivotal role in the prehistory of the human species. It represents the most common parent maternal lineage of all people outside Africa, and for many individuals within the continent as well.[3][4]
Origin
![](http://upload.wikimedia.org/wikipedia/commons/thumb/a/ab/World_map_of_prehistoric_human_migrations.jpg/220px-World_map_of_prehistoric_human_migrations.jpg)
Haplogroup L3's exact place of origin is uncertain. According to the Recent African origin of modern humans (Out-of-Africa) theory, the clade is believed to have arisen and dispersed from East Africa, initially thought to have occurred between 84,000 and 104,000 years ago.[5] An analysis of 369 complete African L3 sequences placed the maximal date of the clade's expansion at around 70,000 years ago. This virtually rules out a successful exit out of Africa before 74,000, the date of the Toba volcanic super-eruption in Sumatra [1], thus making an origin around 70,000 bc most likely. The Time to Most Recent Common Ancestor for the L3 lineage has also recently been estimated to date to between 58,900 and 70,200 years ago, around the time of and associated with the Out-of-Africa expansion of the ancestors of non-African modern humans from Eastern Africa into Eurasia around 70,000 years ago, and also with a similar expansion within Africa around that time also from the East of the continent.[1]
An Asia center of origin and dispersal for haplogroup L3 has also been hypothesized based on the similar coalescence dates of L3 and its Eurasian-distributed M and N derivative clades (~71 kya), the distant location in Southeast Asia of the oldest subclades of M and N, and the comparable age of the paternal haplogroup DE. According to this hypothesis, after an initial Out-of-Africa migration of early anatomically modern humans around 125 kya, fully modern human L3-carrying females are thus proposed to have back-migrated from the maternal haplogroup's place of origin in Eurasia around 70 kya along with males bearing the paternal haplogroup E, which is also proposed to have originated in Eurasia. These new Eurasian lineages are then suggested to have largely replaced the old autochthonous male and female North-East African lineages and later re-entered Eurasia.[6]
Phylogenetically, haplogroup L6 and L4 are the closest to L3 out of the L lineages. Both L6 and L4 are primarily distributed and have their greatest diversity in Eastern Africa. L4'6 (L3'4'6) has a TMRCA of 114,288 years before present while L3'4 link at 95,240 ybp in the middle paleolithic.[3]
Genome study 2018
A research about ancient DNA supports an Asian origin of paternal haplogroup DE and maternal haplogroup L3. The study suggest a back migration into Africa and a following admixture of the native Africans with immigrating Asians. It is suggested L3 originated somewhere near Tibet and Central-Asia.[7]
Distribution
![](http://upload.wikimedia.org/wikipedia/commons/thumb/2/2a/Interpolation_maps_for_L3_total_haplogroups.png/220px-Interpolation_maps_for_L3_total_haplogroups.png)
L3 is common in Northeast Africa and some other parts of East Africa,[8] in contrast to others parts of Africa where the haplogroups L1 and L2 represent around two thirds of mtDNA lineages.[9] L3 sublineages are also frequent in the Arabian peninsula.
L3 is subdivided into several clades, two of which spawned the macrohaplogroups M and N that are today carried by most people outside Africa.[9] There is at least one relatively deep non-M, non-N clade of L3 outside Africa, L3f1b6, which is found at a frequency of 1% in Asturias, Spain. It diverged from African L3 lineages at least 10,000 years ago.[10]
According to Maca-Meyer et al. (2001), "L3 is more related to Eurasian haplogroups than to the most divergent African clusters L1 and L2".[11] L3 is the haplogroup from which all modern humans outside Africa derive.[12] However, there is a greater diversity of major L3 branches within Africa than outside of it, the two major non-African branches being the L3 offshoots M and N.
Haplogroup L3 has been observed in an ancient fossil belonging to the Pre-Pottery Neolithic B culture.[13] L3x2a was observed in a 4,500 year old hunter-gather excavated in Mota, Ethiopia, with the ancient fossil found to be most closely related to the modern Ari foragers.[14][15] Haplogroup L3 has also been found among ancient Egyptian mummies excavated at the Abusir el-Meleq archaeological site in Middle Egypt, which date from the Pre-Ptolemaic/late New Kingdom and Ptolemaic periods.[16] Additionally, haplogroup L3 has been observed in ancient Guanche fossils excavated in Gran Canaria and Tenerife on the Canary Islands, which have been radiocarbon-dated to between the 7th and 11th centuries CE. All of the clade-bearing individuals were inhumed at the Gran Canaria site, with most of these specimens found to belong to the L3b1a subclade (3/4; 75%). The Guanche skeletons also bore an autochthonous Maghrebi genomic component that peaks among modern Berbers, which suggests that they originated from ancestral Berber populations inhabiting northwestern Affoundnat a high ncy[17]
Subclade distribution
![](http://upload.wikimedia.org/wikipedia/commons/thumb/b/b3/Interpolation_maps_for_L3b%2C_L3d%2C_L3e%2C_L3f_L3h%2C_L3i%2C_L3x_and_L3w_haplogroups.png/220px-Interpolation_maps_for_L3b%2C_L3d%2C_L3e%2C_L3f_L3h%2C_L3i%2C_L3x_and_L3w_haplogroups.png)
L3 has seven equidistant descendants: L3a, L3b'f, L3c'd, L3e'i'k'x, L3h, M, N. Five are African, while two are associated with the Out of Africa event.
- N – Eurasia and parts of Africa due to back-migration.[4][6]
- M – Asia, the Mediterranean Basin, and parts of Africa due to back-migration.[4][6]
- L3a – East Africa.[3][4] Moderate to high frequencies found among the Sanye, Samburu, Iraqw, Yaaku, El-Molo and other minor indigenous populations from the East African Rift Valley. It is infrequent to nonexistent in Sudan and the Sahel zone.[18]
- L3b'f
- L3b – Spread from East Africa in the upper paleolithic to West-Central Africa. Some subclades spread from Central Africa to East Africa with the Bantu migration.[4]
- L3f – Northeast Africa, Sahel, Arabian peninsula, Iberia. Gaalien,[21] Beja[21]
- L3f1
- L3f2 – Primarily distributed in East Africa.[4] Also found in North Africa and Central Africa.[20]
- L3f3 – Spread from Eastern Africa to Chad and the Sahel around 8-9 ka.[4] Found in the Chad Basin.[20][22]
- L3c'd
- L3c – Extremely rare lineage with only two samples found so far in Eastern Africa and the Near East.[4]
- L3d – Spread from East Africa in the upper paleolithic to Central Africa. Some subclades spread to East Africa with the Bantu migration.[4] Found among the Fulani,[3] Chadians,[3] Ethiopians,[23] Akan people,[24] Mozambique,[23] Yemenites,[23] Egyptians, Berbers[25]
- L3e'i'k'x
- L3e – Spread from East Africa in the upper paleolithic to West-Central Africa. It is the most common L3 sub-clade in Bantu-speaking populations.[26] L3e is suggested to be associated with a Central African origin and is also the most common L3 subclade amongst African Americans, Afro-Brazilians and Caribbeans[27]
- L3e1 – Spread from West-Central Africa to Southwest Africa with the Bantu migration. Found in Angola (6.8%).[28] Mozambique, Sudanese and Kikuyu from Kenya as well as in Yemen and among the Akan people[24]
- L3e5 – Originated in the Chad Basin. Found in Algeria,[29] as well as Burkina Faso, Nigeria, South Tunisia, South Morocco and Egypt[30]
- L3i Almost exclusively found in East Africa.[4]
- L3k – Rare haplogroup primarily found in North Africa and the Sahel.[4][20]
- L3x – Almost exclusively found in East Africa.[4] Found among Ethiopian Oromos,[23] Egyptians[Note 2][31]
- L3e – Spread from East Africa in the upper paleolithic to West-Central Africa. It is the most common L3 sub-clade in Bantu-speaking populations.[26] L3e is suggested to be associated with a Central African origin and is also the most common L3 subclade amongst African Americans, Afro-Brazilians and Caribbeans[27]
- L3h – Almost exclusively found in East Africa.[4]
- L3h1 – Primarily found in East Africa with branches of L3h1b1 sporadically found in the Sahel and North Africa.[19][20]
- L3h2 – Found in Northeast Africa and Socotra. Split from other L3h branches as early as 65-69 ka during the middle paleolithic.[19][20]
Tree
This phylogenetic tree of haplogroup L3 subclades is based on the paper by Mannis van Oven and Manfred Kayser Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation[2] and subsequent published research.[32]
Most Recent Common Ancestor (MRCA)
- L1-6
- L2-6
- L2'3'4'6
- L3'4'6
- L3'4
- L3
- L3a
- L3a1
- L3a1a
- L3a1b
- L3a2
- L3a2a
- L3a1
- L3b'f
- L3b
- L3b1
- L3b1a
- L3b1a1
- L3b1a2
- L3b1a3
- L3b1a4
- L3b1a5
- L3b1a5a
- L3b1a6
- L3b1a7
- L3b1a7
- L3b1a8
- L3b1a9
- L3b1a9a
- L3b1a10
- L3b1a11
- L3b1b
- L3b1b1
- L3b1a
- L3b2
- L3b2a
- L3b2a
- L3b3
- L3b1
- L3f
- L3f1
- L3f1a
- L3f1a1
- L3f1b
- L3f1b1
- L3f1b2
- L3f1b2a
- L3f1b3
- L3f1b4
- L3f1b4a
- L3f1b4a1
- L3f1b4b
- L3f1b4c
- L3f1b4a
- L3f1b5
- L3f1a
- L3f2
- L3f2a
- L3f2b
- L3f3
- L3f3a
- L3f3b
- L3f1
- L3b
- L3c'd
- L3c
- L3d
- L3d1-5
- L3d1
- L3d1a
- L3d1a1
- L3d1a1a
- L3d1a1
- L3d1b
- L3d1b1
- L3d1c
- L3d1d
- L3d1a
- 199
- L3d2
- L3d5
- L3d3
- L3d3a
- L3d4
- L3d5
- L3d1
- L3d1-5
- L3e'i'k'x
- L3e
- L3e1
- L3e1a
- L3e1a1
- L3e1a1a
- 152
- L3e1a2
- L3e1a3
- L3e1a1
- L3e1b
- L3e1c
- L3e1d
- L3e1e
- L3e1a
- L3e2
- L3e2a
- L3e2a1
- L3e2a1a
- L3e2a1b
- L3e2a1b1
- L3e2a1
- L3e2b
- L3e2b1
- L3e2b1a
- L3e2b2
- L3e2b3
- L3e2b1
- L3e2a
- L3e3'4'5
- L3e3'4
- L3e3
- L3e3a
- L3e3b
- L3e3b1
- L3e4
- L3e3
- L3e5
- L3e3'4
- L3e1
- L3i
- L3i1
- L3i1a
- L3i1b
- L3i2
- L3i1
- L3k
- L3k1
- L3x
- L3x1
- L3x1a
- L3x1a1
- L3x1a2
- L3x1b
- L3x1a
- L3x2
- L3x2a
- L3x2a1
- L3x2a1a
- L3x2a1
- L3x2b
- L3x2a
- L3x1
- L3e
- L3h
- L3h1
- L3h1a
- L3h1a1
- L3h1a2
- L3h1a2a
- L3h1a2b
- L3h1b
- L3h1b1
- L3h1b1a
- L3h1b1a1
- L3h1b1a
- L3h1b2
- L3h1b1
- L3h1a
- L3h2
- L3h1
- M
- N
- L3a
- L3
- L3'4
- L3'4'6
- L2'3'4'6
- L2-6
See also
![](http://upload.wikimedia.org/wikipedia/en/thumb/4/4a/Commons-logo.svg/30px-Commons-logo.svg.png)
Phylogenetic tree of human mitochondrial DNA (mtDNA) haplogroups | |||||||||||||||||||||||||||||||||||||||
Mitochondrial Eve (L) | |||||||||||||||||||||||||||||||||||||||
L0 | L1–6 | ||||||||||||||||||||||||||||||||||||||
L1 | L2 | L3 | L4 | L5 | L6 | ||||||||||||||||||||||||||||||||||
M | N | ||||||||||||||||||||||||||||||||||||||
CZ | D | E | G | Q | O | A | S | R | I | W | X | Y | |||||||||||||||||||||||||||
C | Z | B | F | R0 | pre-JT | P | U | ||||||||||||||||||||||||||||||||
HV | JT | K | |||||||||||||||||||||||||||||||||||||
H | V | J | T |
References
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- ^ Llorente, M. Gallego; Jones, E. R.; Eriksson, A.; Siska, V.; Arthur, K. W.; Arthur, J. W.; Curtis, M. C.; Stock, J. T.; Coltorti, M. (2015-11-13). "Ancient Ethiopian genome reveals extensive Eurasian admixture in Eastern Africa". Science. 350 (6262): 820–822. Bibcode:2015Sci...350..820L. doi:10.1126/science.aad2879. PMID 26449472.
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Notes
- ^ See Supplemental_TreeUpdatedOctober.xls found under the Supplementary data of Soares et al. 2011 harvnb error: multiple targets (3×): CITEREFSoaresAlshamaliPereiraFernandes2011 (help)
- ^ GUR46 on table 1. is a mtDNA haplogroup L3x2a.
External links
- General
- Ian Logan's Mitochondrial DNA Site
- Haplogroup L3
- Mannis van Oven's PhyloTree.org – mtDNA subtree L3
- Spread of Haplogroup L3, from National Geographic