(pyruvate dehydrogenase (acetyl-transferring))-phosphatase

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[pyruvate dehydrogenase (lipoamide)] phosphatase
EC no.
CAS no.9073-70-5
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase (EC is an enzyme that catalyzes the chemical reaction

[pyruvate dehydrogenase (acetyl-transferring)] phosphate + H2O [pyruvate dehydrogenase (acetyl-transferring)] + phosphate

Thus, the two substrates of this enzyme are pyruvate dehydrogenase (acetyl-transferring) phosphate and H2O, whereas its two products are pyruvate dehydrogenase (acetyl-transferring) and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is [pyruvate dehydrogenase (acetyl-transferring)]-phosphate phosphohydrolase. Other names in common use include pyruvate dehydrogenase phosphatase, phosphopyruvate dehydrogenase phosphatase, [pyruvate dehydrogenase (lipoamide)]-phosphatase, and [pyruvate dehydrogenase (lipoamide)]-phosphate phosphohydrolase.

Structural studies[edit]

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2PNQ.


  • Linn TC, Pelley JW, Pettit FH, Hucho F, Randall DD, Reed LJ (1972). "-Keto acid dehydrogenase complexes. XV. Purification and properties of the component enzymes of the pyruvate dehydrogenase complexes from bovine kidney and heart". Arch. Biochem. Biophys. 148 (2): 327–42. doi:10.1016/0003-9861(72)90151-8. PMID 4401694.
  • Reed LJ, Damuni Z, Merryfield ML (1985). "Regulation of mammalian pyruvate and branched-chain alpha-keto acid dehydrogenase complexes by phosphorylation-dephosphorylation". Curr. Top. Cell. Regul. Current Topics in Cellular Regulation. 27: 41–9. doi:10.1016/b978-0-12-152827-0.50011-6. ISBN 9780121528270. PMID 3004826.