After the 1994 season was ended due to the players' strike, there was still a deal that had to be worked out. However, it wasn't until major league owners parlayed plans to have replacement players play in 1995 that the players got into serious negotiations. Due to the strike, there was no official defending champion for the year. However, the negotiations pushed the start of the season back to late-April, already 18 games into a regular season.
Despite the strike, which alienated many fans, Baltimore Orioles shortstop Cal Ripken, Jr. surpassed Lou Gehrig's consecutive games played streak when he played in his 2,131st straight game on September 6. Games during the playoffs were also broadcast simultaneously, meaning that games were only broadcast regionally. Despite the craziness, the 1995 season is now considered a financial success where the two best teams in baseball (in their leagues) met up in the World Series, the Cleveland Indians and Atlanta Braves. For the first time since 1954, the Indians were the AL representatives in the World Series. This came on the heels of dominating the AL Central (beating second place Kansas City by 30 games).
In the NLDS, it was the near-opposite to the New York/Seattle series. The Cincinnati Reds, who'd run away with the NL Central, swept the Dodgers and the Atlanta Braves took both games vs. Colorado at Coors Field before the Rockies finally won a game in game 3. However, the Braves finished off the Rockies at home in game 4. Then, in the NLCS, after taking both games at Riverfront Stadium, the Braves finished the sweep of the Reds at home.
In the 1995 World Series, the Braves took the first two at home vs. Cleveland. Then, during the three games at Jacobs Field, the Indians won games 3 and 5 but those games sandwiched around the Braves 5–2 game 4 victory. In game 6, the Braves, on the power of an 8-inning, one-hitter thrown by Tom Glavine and David Justice hitting a solo home run in the fifth inning, won 1–0 and won the World Series. The victory made the Braves the first team to win World Series in three different home cities (Boston (1914), Milwaukee (1957), and Atlanta (1995)).
April 25 – Major League Baseball begins its strike-shortened 144-game season. Opening day games see fan protests regarding the strike spill onto the field. In addition, there were boos at opening day games.
September 6 – Cal Ripken, Jr. of the Baltimore Orioles plays in his 2,131st consecutive major league game to surpass Lou Gehrig's 56-year record. When the game becomes official in the middle of the fifth inning, Ripken takes a victory lap around Camden Yards during the 22-minute standing ovation from the sellout crowd, including President Bill Clinton. In the game, Ripken goes 2-for-4, including a home run, in Baltimore's 4–2 win over California.
September 28 – Greg A. Harris of the Montréal Expos becomes the first major league pitcher since 1893 to pitch with both hands in one game. Harris faces four batters, two from his usual right side and two from the left, in the ninth inning of a 9–7 loss to the Cincinnati Reds.
January 18 – Ron Luciano, 57, American League umpire from 1968 to 1980 known for his flamboyance and several books
February 7 – Cecil Upshaw, 52, relief pitcher, mainly for the Atlanta Braves, who saved 27 games in 1969 but missed the next season after nearly severing a finger
March 5 – Roy Hughes, 84, infielder for four teams who scored 112 runs for 1936 Indians
March 13 – Leon Day, 78, All-Star pitcher for the Newark Eagles of the Negro Leagues who was elected to the Hall of Fame just six days earlier; set several league strikeout marks, including 18 strikeouts in one game
March 29 – Terry Moore, 82, All-Star center fielder for the Cardinals who batted .304 in 1940, captained 1942 and 1946 champions
April 9 – Bob Allison, 60, All-Star outfielder for the Senators/Twins who was the 1959 Rookie of the Year, had three 30-HR seasons and led the AL in triples and runs once each
May 7 – Gus Bell, 66, All-Star outfielder, mainly with the Reds, who had four 100-RBI seasons and led the NL in triples in 1951; oldest in a major league family that includes son Buddy and grandson David
May 30 – Glenn Burke, 42, center fielder for the Dodgers and Athletics who was the first former major leaguer to publicly acknowledge his homosexuality
June 9 – Zoilo Versalles, 55, Cuban All-Star shortstop who led Twins to the 1965 AL pennant; first Latin American player to be named MVP, led AL in triples three times and in doubles and runs once each
June 10 – Lindsey Nelson, 76, broadcaster for the Mets from 1962 to 1979, and also for the San Francisco Giants and NBC
July 27 – Rick Ferrell, 89, Hall of Fame catcher for the Browns, Red Sox and Senators whose 1806 games caught were an AL record until 1988; from 1934–38, half of a battery with brother Wes
August 3 – Harry Craft, 80, manager of the Houston Colt .45s in their 1962 debut; former Reds center fielder also managed the Kansas City Athletics and Chicago Cubs
August 4 – Dick Bartell, 87, All-Star shortstop for five teams, known for his combative personality, who batted .300 five times and scored 100 runs three times; batted .381 for Giants in 1936 World Series
August 13 – Mickey Mantle, 63, Hall of Fame center fielder for the Yankees who was the AL's MVP in 1956, 1957 and 1962 and won the 1956 Triple Crown; 16-time All-Star won four home run titles, hitting 50 twice, and retired with third most HRs (536) and walks (1733) in history; 10-time .300 hitter led AL in runs six times; most powerful switch-hitter in baseball history, with career marks for runs (1677), RBI (1509) and slugging percentage (.557), and successor to Babe Ruth and Joe DiMaggio as symbol of the Yankees' long reign; hit record 18 home runs in World Series play
August 20 – Von McDaniel, 56, pitcher who joined his brother Lindy on the 1957–58 St. Louis Cardinals, winning seven games
September 21 – Tony Cuccinello, 87, All-Star second baseman for five teams who lost 1945 batting title by one point in his final season; later a coach
September 21 – Andrew Rozdilsky, 77, who performed as Andy the Clown at White Sox games from 1960 to 1990
October 21 – Vada Pinson, 57, twice a National League All-Star outfielder; finished his career with 2,757 hits in 18 seasons
December 27 – Oscar Judd, 87, Canadian pitcher who was an American League All-Star in 1943