2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase
| 2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.302 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase (EC 1.1.1.302, 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase, MjaRED, MJ0671 (gene)) is an enzyme with systematic name 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one:NAD(P)+ oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction
- 2,5-diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one + NAD(P)+ 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + NAD(P)H + H+
The reaction proceeds in the opposite direction. A step in riboflavin biosynthesis, NADPH and NADH functions equally well as a reductant.
References
- ^ Graupner, M.; Xu, H.; White, R.H. (2002). "The pyrimidine nucleotide reductase step in riboflavin and F420 biosynthesis in archaea proceeds by the eukaryotic route to riboflavin". J. Bacteriol. 184 (7): 1952–1957. doi:10.1128/JB.184.7.1952-1957.2002. PMC 134922. PMID 11889103.
- ^ Chatwell, L.; Krojer, T.; Fidler, A.; Romisch, W.; Eisenreich, W.; Bacher, A.; Huber, R.; Fischer, M. (2006). "Biosynthesis of riboflavin: structure and properties of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5′-phosphate reductase of Methanocaldococcus jannaschii". J. Mol. Biol. 359 (5): 1334–1351. doi:10.1016/j.jmb.2006.04.045. PMID 16730025.
External links
- 2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone+5'-phosphate+reductase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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