Alcohol oxidase

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alcohol oxidase
Vanillyl-alcohol oxidase oktamer, Penicillium simplicissimum
EC number1.1.3.13
CAS number9073-63-6
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, an alcohol oxidase (EC is an enzyme that catalyzes the chemical reaction

a primary alcohol + O2 an aldehyde + H2O2

Thus, the two substrates of this enzyme are primary alcohol and O2, whereas its two products are aldehyde and H2O2.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of the donor with oxygen as the acceptor. The systematic name of this enzyme class is alcohol:oxygen oxidoreductase. This enzyme is also called ethanol oxidase. It employs one cofactor, FAD.

Structural studies[edit]

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes 1AHU, 1AHV, 1AHZ, 1VAO, 1W1J, 1W1K, 1W1L, 1W1M, and 2VAO.


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  • Nishida A, Ishihara T, Hiroi T (1987). "Studies on enzymes related to lignan biodegradation". Baiomasu Henkan Keikaku Kenkyu. Hokoku: 38&ndash, 59.
  • Suye S (1997). "Purification and properties of alcohol oxidase from Candida methanosorbosa M-2003". Curr. Microbiol. 34 (6): 374&ndash, 7. doi:10.1007/s002849900198. PMID 9142745.