The game featured the MLS All-Stars against Roma from Italy's Serie A, marking the first time that an Italian team has played in the MLS All-Star Game. Roma is also the first European club not from Great Britain to play in the All-Star Game.
Peter Vermes, the coach of Sporting Kansas City (the All-Star Game's host), was announced to coach the MLS All-Stars. A unique feature of this year's MLS All-Star Game was that the 11th player in the fan XI was decided through the FIFA 13video game, with players from around the world scoring goals with their player of choice, and the player with the most goals scored at the end of the allotted time frame would earn their place. ItalianMontreal Impact striker Marco Di Vaio made the cut, joining the ten other fan XI players and those voted for by other MLS players and those chosen by Peter Vermes and MLS Commissioner Don Garber. Despite initially being selected, Robbie Keane and Tim Cahill, of LA Galaxy and New York Red Bulls, were both removed from the squad due to injury, which led to their being replaced by Landon Donovan and Jack McInerney, playing for LA Galaxy and Philadelphia Union.