3-hydroxypropionate dehydrogenase (NADP+)
| 3-hydroxypropionate dehydrogenase (NADP+) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.298 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
3-hydroxypropionate dehydrogenase (NADP+) (EC 1.1.1.298) is an enzyme with systematic name 3-hydroxypropionate:NADP+ oxidoreductase.[1][2][3] This enzyme catalyses the following chemical reaction
- 3-hydroxypropionate + NADP+ malonate semialdehyde + NADPH + H+
This enzyme catalyses the reduction of malonate semialdehyde to 3-hydroxypropionate, which is a key step in the 3-hydroxypropionate and the 3-hydroxypropionate/4-hydroxybutyrate cycles, autotrophic CO2 fixation pathways found in some green non-sulfur phototrophic bacteria and archaea, respectively. The enzyme from Chloroflexus aurantiacus is bifunctional, and also catalyses the upstream reaction in the pathway, EC 1.2.1.75. Different from EC 1.1.1.59, 3-hydroxypropionate dehydrogenase (NAD+), by cofactor preference.
References
- ^ Strauss, G.; Fuchs, G. (1993). "Enzymes of a novel autotrophic CO2 fixation pathway in the phototrophic bacterium Chloroflexus aurantiacus, the 3-hydroxypropionate cycle". Eur. J. Biochem. 215: 633–643. doi:10.1111/j.1432-1033.1993.tb18074.x. PMID 8354269.
- ^ Berg, I. A.; Kockelkorn, D.; Buckel, W.; Fuchs, G. (2007). "A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea". Science. 318: 1782–1786. doi:10.1126/science.1149976. PMID 18079405.
- ^ Hugler, M.; Menendez, C.; Schagger, H.; Fuchs, G. (2002). "Malonyl-coenzyme A reductase from Chloroflexus aurantiacus, a key enzyme of the 3-hydroxypropionate cycle for autotrophic CO2 fixation". J. Bacteriol. 184 (9): 2404–2410. doi:10.1128/jb.184.9.2404-2410.2002. PMC 134993. PMID 11948153.
External links
- 3-hydroxypropionate+dehydrogenase+(NADP+) at the U.S. National Library of Medicine Medical Subject Headings (MeSH)