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6'''-Hydroxyneomycin C oxidase

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6'''-hydroxyneomycin C oxidase
Identifiers
EC no.1.1.3.44
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BRENDABRENDA entry
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6'''-hydroxyneomycin C oxidase (EC 1.1.3.44, neoG (gene)) is an enzyme with systematic name 6'''-deamino-6'''-hydroxyneomycin C:oxygen 6'''-oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction

6'''-deamino-6'''-hydroxyneomycin C + O2 6'''-deamino-6'''-oxoneomycin C + H2O2

This enzyme participates in biosynthesis of aminoglycoside antibiotics of the neomycin family.

References

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  1. ^ Huang F, Spiteller D, Koorbanally NA, Li Y, Llewellyn NM, Spencer JB (February 2007). "Elaboration of neosamine rings in the biosynthesis of neomycin and butirosin". ChemBioChem. 8 (3): 283–8. doi:10.1002/cbic.200600371. PMID 17206729.
  2. ^ Clausnitzer D, Piepersberg W, Wehmeier UF (September 2011). "The oxidoreductases LivQ and NeoQ are responsible for the different 6'-modifications in the aminoglycosides lividomycin and neomycin". Journal of Applied Microbiology. 111 (3): 642–51. doi:10.1111/j.1365-2672.2011.05082.x. PMID 21689223.
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