Jump to content

CYP11 family

From Wikipedia, the free encyclopedia

This is an old revision of this page, as edited by Citation bot (talk | contribs) at 20:29, 25 January 2021 (Alter: journal, pages. Add: s2cid. Formatted dashes. | You can use this bot yourself. Report bugs here. | Suggested by Headbomb | All pages linked from cached copy of Wikipedia:WikiProject_Academic_Journals/Journals_cited_by_Wikipedia/Sandbox | via #UCB_webform_linked 32/356). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

The evolutionary divergence of the CYP superfamily collected in 1990, CYP11, CYP10 and CYP27 are in the same branch,[1] which is now called Mitochondrial clan CYPs[2].

Cytochrome P450, family 11, also known as CYP11, is a chordate cytochrome P450 monooxygenase family. This family contains many enzymes involved in steroidogenesis, such as Cholesterol side-chain cleavage enzyme (CYP11A1), Steroid 11β-hydroxylase (CYP11B1) and Aldosterone synthase (CYP11B2).[3] CYP11 can be divided into A to E five subfamilies,[4] and CYP11A are the ohonologues to CYP11C, which duplicated during 2R event, and the tetrapod's CYP11B evolved from CYP11C of its fish ancestors,[2] CYP11D and F found in amphioxus.[4] These are not the typical CYP subfamilies, which share at least 40% amino acid identity,[5] members between CYP11A and B subfamily are only 37.5-38.8% identical[6],and the CYP11D and E genes seen in modern lancelet (Branchiostoma floridae, an ancient branch of chordate animals) is 39% identical to catfish CYP11A1.[2][4]

References

  1. ^ Nebert, DW; Nelson, DR; Coon, MJ; Estabrook, RW; Feyereisen, R; Fujii-Kuriyama, Y; Gonzalez, FJ; Guengerich, FP; Gunsalus, IC; Johnson, EF (January 1991). "The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature". DNA and Cell Biology. 10 (1): 1–14. doi:10.1089/dna.1991.10.1. PMID 1991046.
  2. ^ a b c Nelson DR, Goldstone JV, Stegeman JJ (February 2013). "The cytochrome P450 genesis locus: the origin and evolution of animal cytochrome P450s". Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 368 (1612): 20120474. doi:10.1098/rstb.2012.0474. PMC 3538424. PMID 23297357.
  3. ^ Omura, T (27 October 2006). "Mitochondrial P450s". Chemico-biological Interactions. 163 (1–2): 86–93. doi:10.1016/j.cbi.2006.06.008. PMID 16884708.
  4. ^ a b c Baker, ME; Nelson, DR; Studer, RA (July 2015). "Origin of the response to adrenal and sex steroids: Roles of promiscuity and co-evolution of enzymes and steroid receptors". The Journal of Steroid Biochemistry and Molecular Biology. 151: 12–24. doi:10.1016/j.jsbmb.2014.10.020. PMID 25445914. S2CID 21649057.
  5. ^ Nelson, DR (2006). Cytochrome P450 nomenclature, 2004. Methods in Molecular Biology (Clifton, N.J.). Vol. 320. pp. 1–10. doi:10.1385/1-59259-998-2:1. ISBN 1-59259-998-2. PMID 16719369.
  6. ^ Nebert, DW; Nelson, DR; Adesnik, M; Coon, MJ; Estabrook, RW; Gonzalez, FJ; Guengerich, FP; Gunsalus, IC; Johnson, EF; Kemper, B (January 1989). "The P450 superfamily: updated listing of all genes and recommended nomenclature for the chromosomal loci". DNA (Mary Ann Liebert, Inc.). 8 (1): 1–13. doi:10.1089/dna.1.1989.8.1. PMID 2651058.
Stub icon

This genetics article is a stub. You can help Wikipedia by expanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=CYP11_family&oldid=1002731654"