CYP4F12

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Cytochrome P450, family 4, subfamily F, polypeptide 12
Identifiers
Symbols CYP4F12 ; F22329_1
External IDs OMIM611485 MGI1927669 HomoloGene81872 GeneCards: CYP4F12 Gene
EC number 1.14.14.1
RNA expression pattern
PBB GE CYP4F12 206539 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 66002 64385
Ensembl ENSG00000186204 ENSMUSG00000024292
UniProt Q9HCS2 Q9EP75
RefSeq (mRNA) NM_023944 NM_001204333
RefSeq (protein) NP_076433 NP_001191262
Location (UCSC) Chr 19:
15.78 – 15.81 Mb
Chr 17:
32.91 – 32.92 Mb
PubMed search [1] [2]

Cytochrome P450 4F12 is a protein that in humans is encoded by the CYP4F12 gene.[1][2]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein likely localizes to the endoplasmic reticulum. When expressed in yeast the enzyme is capable of oxidizing arachidonic acid; however, its physiological function has not been determined. This gene is part of a cluster of cytochrome P450 genes on chromosome 19.[2]

References[edit]

  1. ^ Bylund J, Bylund M, Oliw EH (Feb 2001). "cDna cloning and expression of CYP4F12, a novel human cytochrome P450". Biochem Biophys Res Commun 280 (3): 892–7. doi:10.1006/bbrc.2000.4191. PMID 11162607. 
  2. ^ a b "Entrez Gene: CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12". 

Further reading[edit]