Cytochrome P450 4F12 is a protein that in humans is encoded by the CYP4F12gene.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein likely localizes to the endoplasmic reticulum. When expressed in yeast the enzyme is capable of oxidizing arachidonic acid; however, its physiological function has not been determined. This gene is part of a cluster of cytochrome P450 genes on chromosome 19.
Knight JA, Fronk S, Haymond RE (1975). "Chemical basis and specificity of chemical screening tests for urinary vanilmandelic acid". Clin. Chem.21 (1): 130–3. PMID1116264.
Hashizume T, Imaoka S, Hiroi T, et al. (2001). "cDNA cloning and expression of a novel cytochrome p450 (cyp4f12) from human small intestine". Biochem. Biophys. Res. Commun.280 (4): 1135–41. doi:10.1006/bbrc.2000.4238. PMID11162645.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet.36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
Stark K, Wongsud B, Burman R, Oliw EH (2005). "Oxygenation of polyunsaturated long chain fatty acids by recombinant CYP4F8 and CYP4F12 and catalytic importance of Tyr-125 and Gly-328 of CYP4F8". Arch. Biochem. Biophys.441 (2): 174–81. doi:10.1016/j.abb.2005.07.003. PMID16112640.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res.12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID16303743.