CYP46A1

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CYP46A1
Protein CYP46A1 PDB 2Q9F.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CYP46A1, CP46, CYP46, cytochrome P450 family 46 subfamily A member 1
External IDs MGI: 1341877 HomoloGene: 134501 GeneCards: CYP46A1
RNA expression pattern
PBB GE CYP46A1 220331 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006668

NM_010010

RefSeq (protein)

NP_006659

NP_034140.1
NP_034140

Location (UCSC) Chr 14: 99.68 – 99.73 Mb Chr 12: 108.33 – 108.36 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Cholesterol 24-hydroxylase is an enzyme that in humans is encoded by the CYP46A1 gene.[3][4]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood–brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism.[4]

References[edit]

Further reading[edit]