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Mevaldate reductase

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mevaldate reductase (NAD+)
Identifiers
EC no.1.1.1.32
CAS no.9028-33-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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In enzymology, a mevaldate reductase (EC 1.1.1.32) is an enzyme that catalyzes the chemical reaction

(R)-mevalonate + NAD+ mevaldate + NADH + H+

Thus, the two substrates of this enzyme are (R)-mevalonate and NAD+, whereas its 3 products are mevaldate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-mevalonate:NAD+ oxidoreductase. This enzyme is also called mevalonic dehydrogenase.

References

  • Schlesinger MJ, Coon MJ (1961). "Reduction of mevaldic acid to mevalonic acid by a partial purified enzyme from liver". J. Biol. Chem. 236: 2421–2424.