Jump to content

Acetarsol

From Wikipedia, the free encyclopedia

This is an old revision of this page, as edited by Citation bot (talk | contribs) at 22:30, 14 March 2020 (Removed URL that duplicated unique identifier. Removed parameters. | You can use this bot yourself. Report bugs here. | Activated by User:AManWithNoPlan | All pages linked from User:AManWithNoPlan/sandbox2 | via #UCB_webform_linked). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Acetarsol
Kekulé, skeletal formula of acetarsol
Names
Preferred IUPAC name
(3-Acetamido-4-hydroxyphenyl)arsonic acid
Other names
3-Acetamido-4-hydroxyphenylarsonic acid[citation needed]
Acetarsol
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
ECHA InfoCard 100.002.349 Edit this at Wikidata
EC Number
  • 202-582-3
KEGG
MeSH Acetarsol
UNII
UN number 3465
  • InChI=1S/C8H10AsNO5/c1-5(11)10-7-4-6(9(13,14)15)2-3-8(7)12/h2-4,12H,1H3,(H,10,11)(H2,13,14,15) checkY
    Key: ODFJOVXVLFUVNQ-UHFFFAOYSA-N checkY
  • InChI=1/C8H10AsNO5/c1-5(11)10-7-4-6(9(13,14)15)2-3-8(7)12/h2-4,12H,1H3,(H,10,11)(H2,13,14,15)
    Key: ODFJOVXVLFUVNQ-UHFFFAOYAX
  • CC(=O)Nc1cc(ccc1O)[As](O)(O)=O
  • CC(=O)NC1=CC(=CC=C1O)[As](O)(O)=O
Properties
C8H10AsNO5
Molar mass 275.0903 g mol−1
Pharmacology
A07AX02 (WHO) G01AB01 (WHO), P01CD02 (WHO), P51AD05 (WHO)
Hazards
GHS labelling:
GHS06: Toxic GHS09: Environmental hazard
Danger
H301, H331, H410
P261, P273, P301+P310, P311, P501
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)

Acetarsol is an anti-infective.[1]

It was first discovered in 1921 at Pasteur Institute by Ernest Fourneau, and sold under the brand name Stovarsol[2][3]

It has been given in suppositories.[4]

Acetarsol can be used to make Arsthinol, & presumably Acetarsone also.

References

  1. ^ Chen MY, Smith NA, Fox EF, Bingham JS, Barlow D (April 1999). "Acetarsol pessaries in the treatment of metronidazole resistant Trichomonas vaginalis". Int J STD AIDS. 10 (4): 277–80. doi:10.1258/0956462991913943. PMID 12035784.
  2. ^ Éric Fouassier, Ces poisons qui guérissent, oct. 1996, p. 5.
  3. ^ Traité de chimie organique, sous la direction de Victor Grignard, Paul Baud, vol. 22, Masson, 1959, p. 1127-1130.
  4. ^ Gionchetti P, Rizzello F, Morselli C, Campieri M (October 2004). "Review article: problematic proctitis and distal colitis". Aliment. Pharmacol. Ther. 20 Suppl 4: 93–6. doi:10.1111/j.1365-2036.2004.02049.x. PMID 15352902.