Ammonium ferric citrate

Ammonium ferric citrate
	; Structure of ammonium ferric citrate
	; Crystal structure of (NH4)5[Fe(C6H4O7)2]·2H2O
Names
	IUPAC name 2-Hydroxypropane-1,2,3-tricarboxylate, ammonium iron(3+) salt
	Other names Ferric ammonium citrate; Ammonium iron(III) citrate; Ammonium ferric citrate; Iron ammonium citrate; FerriSeltz
Identifiers
CAS Number	1185-57-5 ;
ChEBI	CHEBI:31604;
ChEMBL	ChEMBL1200460 ;
ECHA InfoCard	100.013.351
EC Number	214-686-6;
E number	E381 (antioxidants, ...)
KEGG	D01644;
PubChem CID	44134719; 9881826; 118984355; 14457;
UNII	UVP74NG1C5 ;
CompTox Dashboard (EPA)	DTXSID9040477 ;
	InChI InChI=1S/C6H8O7.Fe.H3N/c7-3(8)1-6(13,5(11)12)2-4(9)10;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;1H3/q;+3;/p-2 Key: FRHBOQMZUOWXQL-UHFFFAOYSA-L ; InChI=1/C6H8O7.Fe.H3N/c7-3(8)1-6(13,5(11)12)2-4(9)10;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;1H3/q;+3;/p-2 Key: FRHBOQMZUOWXQL-NUQVWONBAA;
Properties
Chemical formula	C6H8O7⋅xFe3+⋅yNH3
Appearance	yellow crystals
Pharmacology
ATC code	V08CA07 (WHO)
Hazards
Safety data sheet (SDS)	[1]
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Ammonium ferric citrate has the formula (NH₄)₅[Fe(C₆H₄O₇)₂]. A distinguishing feature of this compound is that it is very soluble in water, in contrast to ferric citrate which is not very soluble.

In its crystal structure each citric acid moiety has lost four protons. The deprotonated hydroxyl group and two of the carboxylate groups ligate to the ferric center, while the third carboxylate group coordinates with the ammonium.^[1]

Uses

Ammonium ferric citrate has a range of uses, including:

As a food additive, where it has the E number E381, and is used as an acidity regulator. Most notably used in the Scottish beverage Irn-Bru.
Water purification.
As a reducing agent of metal salts of low activity like gold and silver.
With potassium ferricyanide as part of the cyanotype photographic process.
Used in Kligler iron deeps to determine hydrogen sulfide production in microbial metabolism.
In medical imaging, ammonium ferric citrate is used as a contrast medium.
As a hematinic.^[3]

References

^ ^a ^b Matzapetakis, M.; Raptopoulou, C. P.; Tsohos, A.; Papaefthymiou, V.; Moon, N.; Salifoglou, A. (1998). "Synthesis, Spectroscopic and Structural Characterization of the First Mononuclear, Water Soluble Iron−Citrate Complex, (NH₄)₅Fe(C₆H₄O₇)₂·2H₂O". J. Am. Chem. Soc. 120 (50): 13266–13267. doi:10.1021/ja9807035.
^ "KEGG DRUG: Ferric ammonium citrate".
^ Budavari, Susan, ed. (2001), The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals (13th ed.), Merck, ISBN 0911910131

[str-1] Matzapetakis, M.; Raptopoulou, C. P.; Tsohos, A.; Papaefthymiou, V.; Moon, N.; Salifoglou, A. (1998). "Synthesis, Spectroscopic and Structural Characterization of the First Mononuclear, Water Soluble Iron−Citrate Complex, (NH₄)₅Fe(C₆H₄O₇)₂·2H₂O". J. Am. Chem. Soc. 120 (50): 13266–13267. doi:10.1021/ja9807035.

[2] "KEGG DRUG: Ferric ammonium citrate".

[merck-3] Budavari, Susan, ed. (2001), The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals (13th ed.), Merck, ISBN 0911910131

[1]

[2]

[3]

Uses

See also

References