Simeticone
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Clinical data | |
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Trade names | Infacol, Wind-eze, WindSetlers, many others |
Other names | simethicone[1] (USAN US) |
AHFS/Drugs.com | Monograph |
Pregnancy category |
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Routes of administration | Oral |
ATC code | |
Legal status | |
Legal status |
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Pharmacokinetic data | |
Bioavailability | None |
Protein binding | 0% |
Metabolism | Not metabolized |
Elimination half-life | N/A |
Excretion | feces |
Identifiers | |
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CAS Number | |
PubChem CID | |
ChemSpider |
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ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.107.016 |
Chemical and physical data | |
Formula | (C2H6OSi)n · (SiO2)m |
Molar mass | variable |
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Simeticone (INN), also known as simethicone (USAN), is an anti-foaming agent used to reduce bloating, discomfort or pain caused by excessive gas.
Medical uses
Simeticone is used to relieve the symptoms of excessive gas in the gastrointestinal tract, namely bloating, burping and flatulence.[2][3] While there is a lack of conclusive evidence that simeticone is effective for this use,[4][5][failed verification] studies have shown that it can relieve symptoms of functional dyspepsia[6] and functional bloating.[7]
Efficacy has not been fully established that simeticone is useful to treat colic in babies,[8] and it is not recommended for this purpose;[5] however, evidence is sparse. In 2017, a study in the United Kingdom reported that according to parental perception simeticone helped infant colic in some cases.[9]
Side effects
Two possible side effects which are uncommon (occurring in 1 in 100 to 1 in 1,000 patients) are constipation and nausea.[10]
Pharmacology
Simeticone is an anti-foaming agent that decreases the surface tension of gas bubbles, causing them to combine into larger bubbles in the digestive tract. Its effectiveness has been shown in several in vitro studies.[11][12]
However, simeticone does not reduce or prevent the formation of gas.[13]
Chemistry
The chemical name for simeticone is α-(trimethylsilyl)-ω-methylpoly[oxy(dimethylsilylene)], mixture with silicon dioxide.[14]
Society and culture
The INN name is "simeticone", which was added to the INN recommended list in 1999.[14]
Simeticone is marketed under many brand names and in many combination drugs; it is also marketed as a veterinary drug.[15]
Brands
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Brand names include A.F., Acid Off, Aero Red, Aero-OM, Aero-Sim, Aerocol, Aerox, Aesim, Aflat, Air-X, Anaflat, Antiflat, Baby Rest, Bicarsim, Bicarsim Forte, Blow-X, Bobotic, Bobotik, Carbogasol, Colic E, Colin, Cuplaton, Degas, Dentinox, Dermatix, Digesta, Dimetikon Meda, Disflatyl, Disolgas, Elugan N, Elzym, Endo-Paractol, Enterosilicona, Espaven Antigas, Espumisan, Espumisan L, Flacol, Flapex, Flatidyl, Flatoril, Flatulex, Flucolic, Gas X, Gas-X, Gaselab, Gaseoflat, Gaseoflatex, Gaseophar, Gaseoplus, Gaseovet, Gaservol, Gasnil, Gasofilm, Gastrex, Gastrosen, Gazim X, Gazix, Geludrox-HS, Genasyme, Ilio-Funkton, Imogas, Imogaze, Imonogas, Infacalm, Infacol, Infacolic, Lefax, Lefaxin, Lefoam, Logastin, Luftal, Maxi Flat, Meteosim, Metiorisan, Metsil, Mylanta, Mylicon, Mylicongas, Mylom, Mymus, Nanog, Neodrop, Neogasol, Neolanta, Orocure, Ovol, Pedicon, Phazin, Phazyme, Restime, Rugby Gas Relief, Sab Simplex, Salinal, Semecon, Semeth, Sicongast, Siflat, Silbione, Siligas, Silipin, Sim, Simcone, Simecon, Simecrin, Simedill, Simegut, Simet, Simethicon, Simethicone, Simetic, Simeticon, Simeticona, Simeticone, Siméticone, Simeticonum, Simetigast, Simflat, Simicol, Simicon, Wilcon, Wind-eze and WindSetlers.[15] It is also marketed as a combination drug:[15]
It is also marketed as veterinary drug under the brands Birp and Methysilox. |
References
- ^ "Simethicone names". Drugs.com. Retrieved 27 August 2017.
- ^ "Simethicone tablet". NIH DailyMed. April 2016. Retrieved 27 August 2017.
- ^ "Simeticone". NHS. 10 October 2019. Retrieved 30 January 2020.
- ^ Modi, Ronak; Clearfield, Harris R.; Levitt, Michael (July 2013). "Belching, Bloating and Flatulence". American College of Gastroenterology.
{{cite web}}
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suggested) (help) - ^ a b "Simethicone". drugs.com.
Efficacy not established for the symptomatic relief of immediate postprandial upper abdominal distress
- ^ Holtmann G, Gschossmann J, Mayr P, Talley NJ (September 2002). "A randomized placebo-controlled trial of simethicone and cisapride for the treatment of patients with functional dyspepsia". Alimentary Pharmacology & Therapeutics. 16 (9). Wiley: 1641–8. doi:10.1046/j.1365-2036.2002.01322.x. PMID 12197843.
- ^ Burta O, Iacobescu C, Mateescu RB, Nicolaie T, Tiuca N, Pop CS (25 September 2018). "Efficacy and safety of APT036 versus simethicone in the treatment of functional bloating: a multicentre, randomised, double-blind, parallel group, clinical study". Translational Gastroenterology and Hepatology. 3 (72). AME Publications: 72. doi:10.21037/tgh.2018.09.11. PMC 6256934. PMID 30511026.
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: CS1 maint: unflagged free DOI (link) - ^ Biagioli E, Tarasco V, Lingua C, Moja L, Savino F (September 2016). "Pain-relieving agents for infantile colic". The Cochrane Database of Systematic Reviews. 9: CD009999. doi:10.1002/14651858.CD009999.pub2. PMC 6457752. PMID 27631535.
- ^ Goldman M, Beaumont T (March 2017). "A real world evaluation of a treatment for infant colic based on the experience and perceptions of 4004 parents". British Journal of Nursing. 26 (5 Suppl 1): S3–S10. doi:10.12968/bjon.2017.26.Sup5.S3. PMID 28350192.
- ^ "Simethicone Side Effects in Detail". Drugs.com. Retrieved 27 August 2017.
- ^ Brecević L, Bosan-Kilibarda I, Strajnar F (May 1994). "Mechanism of antifoaming action of simethicone". Journal of Applied Toxicology. 14 (3). Wiley: 207–11. doi:10.1002/jat.2550140311. PMID 8083482. Retrieved 30 January 2020.
- ^ Dittrich M, Miederer SE, Havertz B, Krastev R (12 May 2010). "Schaumzerstörung und Schaumverhinderung: Der Wirkmechanismus von Simeticon in vitro" [Defoaming and antifoaming action of simethicone in vitro] (PDF). Journal für Gastroenterologische und Hepatologische Erkrankungen. (in German). 8 (3). Krause & Pachernegg: 19–25.
- ^ "Treatment of Gas". International Foundation for Functional Gastrointestinal Disorders. 4 September 2015.
- ^ a b "Recommended INN List 42" (PDF). WHO Drug Information. 13 (3): 202. 1999.
- ^ a b c "Simeticone international brands". Drugs.com. Retrieved 27 August 2017.