Amanullin
Appearance
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Names | |
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Other names
3-Isoleucine-alpha-amanitin
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Identifiers | |
3D model (JSmol)
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ChemSpider | |
PubChem CID
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CompTox Dashboard (EPA)
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Properties | |
C39H54N10O12S | |
Molar mass | 886.86 g/mol |
Appearance | Colorless, crystalline solid |
Soluble | |
Solubility in ethanol, methanol | Soluble |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Amanullin is a cyclic nonribosomal peptide. It is an amatoxin, all of which are found in several members of the Amanita genus of mushrooms. The oral LD50 of amanullin is approximately 20 mg/kg in mice, however it is non-toxic in humans.
Toxicology
Like other amatoxins, amanullin is an inhibitor of RNA polymerase II. Amanullin has a species dependent and specific attraction to the enzyme RNA polymerase II. Upon ingestion, it binds to the RNA polymerase II enzyme, effectively causing cytolysis of hepatocytes (liver cells).[1]
See also
References
- ^ Cochet-Meilhac M, Chambon P (June 1974). "Animal DNA-dependent RNA polymerases. 11. Mechanism of the inhibition of RNA polymerases B by amatoxins". Biochim. Biophys. Acta. 353 (2): 160–84. doi:10.1016/0005-2787(74)90182-8. PMID 4601749.
External links
- Amatoxins REVISED
- Poisonous Mushrooms (German)