Cathepsin F

CTSF
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1M6D
Identifiers
Aliases	CTSF, CATSF, CLN13, cathepsin F
External IDs	OMIM: 603539; MGI: 1861434; HomoloGene: 31194; GeneCards: CTSF; OMA:CTSF - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	66,568,879 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	4,910,946 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; left testis; ; right testis; ; right coronary artery; ; left ovary; ; right frontal lobe; ; right ovary; ; tibial nerve; ; gastric mucosa; ; ascending aorta;
	Top expressed in
	neural layer of retina; ; adrenal gland; ; right kidney; ; choroid plexus of fourth ventricle; ; lip; ; cerebellar cortex; ; primary visual cortex; ; epithelium of lens; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity; cysteine-type peptidase activity; hydrolase activity; cysteine-type endopeptidase activity;
Cellular component	extracellular vesicle; lysosome; lysosomal lumen; extracellular exosome; extracellular space; collagen-containing extracellular matrix;
Biological process	proteolysis involved in cellular protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class II; proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	8722
	56464
	ENSG00000174080
	ENSMUSG00000083282
	Q9UBX1
	Q9R013
	NM_003793
	NM_019861
	NP_003784
	NP_063914
	Wikidata
View/Edit Human	View/Edit Mouse

Cathepsin F is a protein that in humans is encoded by the CTSF gene.^[5]^[6]^[7]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000174080 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000083282 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wang B, Shi GP, Yao PM, Li Z, Chapman HA, Bromme D (Dec 1998). "Human cathepsin F. Molecular cloning, functional expression, tissue localization, and enzymatic characterization". J Biol Chem. 273 (48): 32000–8. doi:10.1074/jbc.273.48.32000. PMID 9822672.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Santamaria I, Velasco G, Pendas AM, Paz A, Lopez-Otin C (Jun 1999). "Molecular cloning and structural and functional characterization of human cathepsin F, a new cysteine proteinase of the papain family with a long propeptide domain". J Biol Chem. 274 (20): 13800–9. doi:10.1074/jbc.274.20.13800. PMID 10318784.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ "Entrez Gene: CTSF cathepsin F".

External links

The MEROPS online database for peptidases and their inhibitors: C01.018

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This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000174080 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000083282 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9822672-5] Wang B, Shi GP, Yao PM, Li Z, Chapman HA, Bromme D (Dec 1998). "Human cathepsin F. Molecular cloning, functional expression, tissue localization, and enzymatic characterization". J Biol Chem. 273 (48): 32000–8. doi:10.1074/jbc.273.48.32000. PMID 9822672.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[pmid10318784-6] Santamaria I, Velasco G, Pendas AM, Paz A, Lopez-Otin C (Jun 1999). "Molecular cloning and structural and functional characterization of human cathepsin F, a new cysteine proteinase of the papain family with a long propeptide domain". J Biol Chem. 274 (20): 13800–9. doi:10.1074/jbc.274.20.13800. PMID 10318784.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[entrez-7] "Entrez Gene: CTSF cathepsin F".

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v t e Proteases: cysteine proteases (EC 3.4.22)
Caspase	Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase 13 Caspase 14
Fruit-derived	Papain Ficain Bromelain Actinidain
Calpain	CAPN1 CAPN2 CAPN3 CAPN5 CAPN6 CAPN7 CAPN8 CAPN9 CAPN10 CAPN11 CAPN12 CAPN13 CAPN14 CAPNS1 CAPNS2
Cathepsin	B C F H K L1/L2 O S W Z
Other	Clostripain Cancer procoagulant Separase Autophagin Cruzipain 3C-like protease Gingipain R Gingipain K

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

References

Further reading

External links