Cyclin E2
| cyclin E2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | CCNE2 | ||||||
| NCBI gene | 9134 | ||||||
| HGNC | 1590 | ||||||
| OMIM | 603775 | ||||||
| RefSeq | NM_057749 | ||||||
| UniProt | O96020 | ||||||
| Other data | |||||||
| Locus | Chr. 8 q22.1 | ||||||
| |||||||
Cyclin E2 is a protein that in humans is encoded by the CCNE2 gene. It is a G1 cyclin that binds Cdk2 and is inhibited by p27(Kip1) and p21(Cip1).[1] It plays a role in the G1/S portion of the cell cycle and also has putative interactions with proteins CDKN1A, CDKN1B, and CDK3. Aberrant expression can lead to cancer.[1]
References
- ^ a b Gudas, Jean M.; Payton, Marc; Thukral, Sushil; Chen, Eddy; Bass, Michael; Robinson, Murray O.; Coats, Steve (1999). "Cyclin E2, a novel G1 cyclin that binds Cdk2 and is aberrantly expressed in human cancers". Molecular and Cellular Biology. 19 (1): 612–22. doi:10.1128/mcb.19.1.612. PMC 83919. PMID 9858585.