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Protein CDKN2D PDB 1bd8.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesCDKN2D, INK4D, p19, p19-INK4D, cyclin-dependent kinase inhibitor 2D, cyclin dependent kinase inhibitor 2D
External IDsOMIM: 600927 MGI: 105387 HomoloGene: 36081 GeneCards: CDKN2D
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for CDKN2D
Genomic location for CDKN2D
Band19p13.2Start10,566,462 bp[1]
End10,569,059 bp[1]
RNA expression pattern
PBB GE CDKN2D 210240 s at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 19: 10.57 – 10.57 MbChr 9: 21.29 – 21.29 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Cyclin-dependent kinase 4 inhibitor D is an enzyme that in humans is encoded by the CDKN2D gene.[5][6]

The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported.[6]

Note, this protein should not be confused with p19-ARF (mouse) or the human equivalent p14ARF, which are alternative products of the CDKN2A gene.


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000129355 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000096472 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Okuda T, Hirai H, Valentine VA, Shurtleff SA, Kidd VJ, Lahti JM, Sherr CJ, Downing JR (Mar 1996). "Molecular cloning, expression pattern, and chromosomal localization of human CDKN2D/INK4d, an inhibitor of cyclin D-dependent kinases". Genomics. 29 (3): 623–30. doi:10.1006/geno.1995.9957. PMID 8575754.
  6. ^ a b "Entrez Gene: CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)".

Further reading[edit]

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