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Cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
Protein CDKN2D PDB 1bd8.png
PDB rendering based on 1bd8.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CDKN2D ; INK4D; p19; p19-INK4D
External IDs OMIM600927 MGI105387 HomoloGene36081 GeneCards: CDKN2D Gene
RNA expression pattern
PBB GE CDKN2D 210240 s at tn.png
More reference expression data
Species Human Mouse
Entrez 1032 12581
Ensembl ENSG00000129355 ENSMUSG00000096472
UniProt P55273 Q60773
RefSeq (mRNA) NM_001800 NM_009878
RefSeq (protein) NP_001791 NP_034008
Location (UCSC) Chr 19:
10.57 – 10.57 Mb
Chr 9:
21.29 – 21.29 Mb
PubMed search [1] [2]

Cyclin-dependent kinase 4 inhibitor D is an enzyme that in humans is encoded by the CDKN2D gene.[1][2]

The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported.[2]

Note, this protein should not be confused with p19-ARF (mouse) or the human equivalent p14-ARF, which are alternative products of the CDKN2a gene.


  1. ^ Okuda T, Hirai H, Valentine VA, Shurtleff SA, Kidd VJ, Lahti JM, Sherr CJ, Downing JR (Mar 1996). "Molecular cloning, expression pattern, and chromosomal localization of human CDKN2D/INK4d, an inhibitor of cyclin D-dependent kinases". Genomics 29 (3): 623–30. doi:10.1006/geno.1995.9957. PMID 8575754. 
  2. ^ a b "Entrez Gene: CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)". 

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