Decaprenylphospho-beta-D-ribofuranose 2-oxidase
| Decaprenylphospho-beta-D-ribofuranose 2-oxidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.98.3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Decaprenylphospho-beta-D-ribofuranose 2-oxidase (EC 1.1.98.3, decaprenylphosphoryl-beta-D-ribofuranose 2'-epimerase, Rv3790, DprE1) is an enzyme with systematic name trans,octacis-decaprenylphospho-beta-D-ribofuranose:FAD 2-oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction
- trans,octacis-decaprenylphospho-beta-D-ribofuranose + FAD trans,octacis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose + FADH2
This enzyme from the bacterium Mycobacterium smegmatis participates in epimerization of trans,octacis-decaprenylphospho-beta-D-ribofuranose to trans,octacis-decaprenylphospho-beta-D-arabinoofuranose.
References
- ^ Ribeiro, A.L.; Degiacomi, G.; Ewann, F.; Buroni, S.; Incandela, M.L.; Chiarelli, L.R.; Mori, G.; Kim, J.; Contreras-Dominguez, M.; Park, Y.S.; Han, S.J.; Brodin, P.; Valentini, G.; Rizzi, M.; Riccardi, G.; Pasca, M.R. (2011). "Analogous mechanisms of resistance to benzothiazinones and dinitrobenzamides in Mycobacterium smegmatis". PLoS ONE. 6 (11): #e26675-e26675. doi:10.1371/journal.pone.0026675. PMC 3206020. PMID 22069462.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Trefzer, C.; Škovierová, H.; Buroni, S.; Bobovská, A.; Nenci, S.; Molteni, E.; Pojer, F.; Pasca, M.R.; Makarov, V.; Cole, S.T.; Riccardi, G.; Mikušová, K.; Johnsson, K. (2012). "Benzothiazinones are suicide inhibitors of mycobacterial decaprenylphosphoryl-β-D-ribofuranose 2′-oxidase DprE1". J. Am. Chem. Soc. 134: 912–915. doi:10.1021/ja211042r. PMID 22188377.
External links
- Decaprenylphospho-beta-D-ribofuranose+2-oxidase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)