Gluconolactonase

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gluconolactonase
Identifiers
EC number3.1.1.17
CAS number9012-73-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a gluconolactonase (EC 3.1.1.17) is an enzyme that catalyzes the chemical reaction

D-glucono-1,5-lactone + H2O D-gluconate

Thus, the two substrates of this enzyme are D-glucono-1,5-lactone and H2O, whereas its product is D-gluconate.

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is D-glucono-1,5-lactone lactonohydrolase. Other names in common use include lactonase, aldonolactonase, glucono-delta-lactonase, and gulonolactonase. This enzyme participates in 3 metabolic pathways: pentose phosphate pathway, ascorbate and aldarate metabolism, and caprolactam degradation.

References[edit]

  • BRODIE AF, LIPMANN F (1955). "Identification of a gluconolactonase". J. Biol. Chem. 212 (2): 677–85. PMID 14353869.
  • Bublitz C; Lehninger AL (1961). "The role of aldonolactonase in the conversion of L-gulonate to L-ascorbate". Biochim. Biophys. Acta. 47 (2): 288–297. doi:10.1016/0006-3002(61)90289-X.
  • Suzuki K, Kawada M, Shimazono N. "Soluble lactonase. Identity of lactonase I and aldonolactonase with gluconolactonase". J. Tokyo. Biochem.: 448–449.