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Glucose 1-dehydrogenase (NAD+)

From Wikipedia, the free encyclopedia
glucose 1-dehydrogenase (NAD+)
Identifiers
EC no.1.1.1.118
CAS no.37250-49-0
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a glucose 1-dehydrogenase (NAD+) (EC 1.1.1.118) is an enzyme that catalyzes the chemical reaction

D-glucose + NAD+ D-glucono-1,5-lactone + NADH + H+

Thus, the two substrates of this enzyme are D-glucose and NAD+, whereas its 3 products are D-glucono-1,5-lactone, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-glucose:NAD+ 1-oxidoreductase. Other names in common use include D-glucose:NAD+ oxidoreductase, D-aldohexose dehydrogenase, and glucose 1-dehydrogenase (NAD+).

Structural studies

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As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2DTD, 2DTE, and 2DTX.

References

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  • Hu AS, Cline AL (November 1964). "The regulation of some sugar dehydrogenases in a pseudomonad". Biochimica et Biophysica Acta (BBA) - General Subjects. 93 (2): 237–45. doi:10.1016/0304-4165(64)90371-x. PMID 14251301.