Glucose 1-dehydrogenase (FAD, quinone)

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glucose 1-dehydrogenase (FAD, quinone)
EC no.
CAS no.37250-84-3
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a glucose 1-dehydrogenase (FAD, quinone) (EC is an enzyme that catalyzes the chemical reaction

D-glucose + a quinone D-glucono-1,5-lactone + a quinol

Thus, the two substrates of this enzyme are D-glucose and a quinone, whereas its two products are D-glucono-1,5-lactone and a quinol.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with other acceptors. The systematic name of this enzyme class is D-glucose:acceptor 1-oxidoreductase. Other names in common use include glucose dehydrogenase (Aspergillus), glucose dehydrogenase (decarboxylating), and D-glucose:(acceptor) 1-oxidoreductase. This enzyme participates in pentose phosphate pathway. It employs one cofactor, FAD.


  • Bak TG (July 1967). "Studies on glucose dehydrogenase of Aspergillus oryzae. II. Purification and physical and chemical properties". Biochimica et Biophysica Acta (BBA) - Enzymology. 139 (2): 277–93. doi:10.1016/0005-2744(67)90032-0. PMID 6034674.