Haplogroup R2

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Haplogroup R2
Possible time of origin 27,000 BP[1]
Possible place of origin South Asia or Central Asia[1]
Ancestor Haplogroup R
Descendants R2a (M124);
R2b (FGC21706)
Defining mutations M479

Haplogroup R2, or R-M479, is a Y-chromosome haplogroup characterized by genetic marker M479. It is one of two primary descendants of Haplogroup R (R-M207), the other being R1 (R-M173).

R-M479 has been concentrated geographically in South Asia and Central Asia since prehistory. It appears to reach its highest levels in North Pakistan. However, it also appears to have long been present at low levels in the Caucasus, Iran, Anatolia and Europe.

It has two primary branches: R2a (M124) and R2b (R-FGC21706)


  • R (M207/Page37/UTY2)
    • R1 (M173/P241/Page29)
    • R2 (M479/PF6107, L266/PF6108, L722, L726)
      • R2a (M124, F820/Page4, L381, P249)
        • R2a1 (L263)
        • R2a2 (P267/PF6109)
      • R2b (FGC21706, FGC50198, FGC50325, FGC50333, SK2163, SK2164, SK2165, SK2166)
        • R2b1 (FGC50339)

Source: ISOGG 2017.[1]

Geographical distribution[edit]

Frequency of R2(xR2a) (M479+, M124-)
Count Sample size Frequency (%)
Lisbon, Portugal 1 100 1.0[citation needed]
Seville, Andalusia, Spain 1 127 0.8[citation needed]
Bashkirs, Bashkortostan, Russia 1 39 2.6[citation needed]
Northern Italy 1 124 0.8[citation needed]
South Ossetia 1 23 4.3[citation needed]
Burusho, Gilgit-Baltistan, Pakistan 7 19 36.8[2]
North Pakistan 6 85 7.1[citation needed]

Most research has tested only for the presence of R-M479 (R2) and R-M124 (R2a) – or SNPs downstream from M124 like P249, P267, L266, PAGES00004, and L381 SNPs). Because the other primary branch, R2b (R-FGC21706) was discovered later than R2a, it has often not been tested for. Hence most results are best described as R2(xR2a).

In addition, relatively little research has been done within South Asia, which is known to have the greatest concentration of R2. (Hence the figures cited in the table right may not be indicative of true frequencies, i.e. Pakistan is the only South Asian country that has been included.)

In 2013, R2(xR2a) was found in five out of 19 males from the Burusho minority of North Pakistan.[2]

R2a (R-M124)[edit]

Haplogroup R2a (R-M124) is characterized by SNPs M124, F820/Page4, L381, P249,[1] and is mainly found in South Asia, with lower frequencies in Central Asia and the Caucasus.[citation needed]

R2b (R-FGC21706)[edit]

Phylogenetic tree[edit]







Description of the SNP M479[edit]

Common Name Marker M479
YCC Haplogroup R-M479
Nucleotide change C to T
Amplicon size (bp) reference sequence 323
Polymorphism position from 5' end 107
Restriction enzyme variant HphI
Y-position 19294055
Primer forward 5'-3' gatactttatcaggcttacttc
Primer reverse 5'-3' aaccaaatctctcagaatcg


See also[edit]

Y-DNA R-M207 subclades[edit]

Y-DNA backbone tree[edit]

Phylogenetic tree of human Y-chromosome DNA haplogroups [χ 1][χ 2]
"Y-chromosomal Adam"
A00 A0-T [χ 3]
A0 A1 [χ 4]
A1a A1b
A1b1 BT
F1  F2  F3  GHIJK
IJ   K
I J     LT [χ 5]  K2
L     T [χ 6] K2a [χ 7] K2b [χ 8]   K2c   K2d  K2e [χ 9]  
K2a1                    K2b1 [χ 10]    P [χ 11]
NO S [χ 12]  M [χ 13]    P1     P2
N O Q     R

External links[edit]