Haplogroup N-M231

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Haplogroup N
Haplogrupo N (ADN-Y).PNG
Possible time of origin 36,800 [95% CI 34,300–39,300] years before present (YFull[1])

41,900 [95% CI 31,294–51,202] years ago[2]
Coalescence age 22,100 [95% CI 19,800–24,400] ybp (YFull[1])

19,153 [95% CI 13,677–24,422] years ago[2]

about 21,000 years ago[3]
Possible place of origin East Asia[4][5]
Ancestor NO
Defining mutations M231
Highest frequencies Nganassan 92%, Yakuts 75%, Nenets 75%, Finns 60%, Baltic States 45% (McDonald 2005), Saami 40%

Haplogroup N (M231) is a Y-chromosome DNA haplogroup typical of Northern Eurasia, which is defined by the presence of the marker M231.[Phylogenetics 1]

Origins[edit]

Estimated prehistoric migration routes for Y-chromosome haplogroup N lineage.[3]

Haplogroup N-M231 is a descendant haplogroup of Haplogroup NO1-M214. Its most recent common ancestor with its nearest outgroup, haplogroup O-M175, is estimated to have lived about 36,800[1] or 41,900[2] years ago. However, extant haplogroup N-M231 is considered to be relatively young, having populated the north of Eurasia after the last Ice Age. Males carrying the marker apparently moved northwards as the climate warmed in the Holocene.

It is suggested that N-M231 arose in Southeast Asia 19.4±4.8 ky years ago, and then migrated in a counter-clockwise path from modern day regions of Mongolia and northern China to as far as northeastern Europe (Rootsi 2006).

The absence of haplogroup N-M231 in the Americas indicates that its spread across Asia happened after the submergence of Beringia (Chiaroni 2009).

Distribution[edit]

Projected distributions of haplogroup N sub-haplogroups.[3] (A) N*-M231, (B) N1*-LLY22g, (C) N1a-M128, (D) N1b-P43, (E) N1c-M46.

Haplogroup N has a wide geographic distribution throughout northern Eurasia, and it also has been observed occasionally in other areas, including Southeast Asia, the Pacific, Southwest Asia and Southern Europe.

Its highest frequency occurs among the Finnic and Baltic peoples of northern Europe, the Ob-Ugric and Northern Samoyedic peoples of western Siberia, and the Siberian Turkic-speaking Yakuts (McDonald 2005).

N* (M231)[edit]

Y-chromosomes that display the M231 mutation that defines Haplogroup N-M231, but do not display the CTS11499, L735, M2291 mutations that define Haplogroup N1 are said to belong to paragroup N-M231*.[4] (A "Haplogroup N2" has also been mooted, defined by F3373, M2283, Page56, and/or S323.)

N-M231* has been found at low levels in China and Cambodia.[4] Out of a sample of 165 Han males from China, two individuals (1.2%) were found to belong to N*.(Karafet 2010).[Footnote 1] One originated from Guangdong and one from Shaanxi.

N1 (CTS11499/L735/M2291)[edit]

Haplogroup N1
Possible place of origin Asia
Ancestor N* (M231)
Defining mutations CTS11499/L735/M2291 (previously LLY22g)

In 2014, LLY22g was retired as a defining SNP for Haplogroup N1; it was replaced by CTS11499/L735/M2291. According to ISOGG, LLY22g is problematic because it is a "palindromic marker and can easily be misinterpreted".[4] Consequently, the position of many previously examples of "N-LLY22g", within N-M231 has become unclear.

N1* has been reported to reach a frequency of up to 30% (13/43) among the Yi people of Butuo County, Sichuan in Southwest China (Hammer 2005, Karafet 2001, and Wen2004b). It is also found in 34.6% of Lhoba people (Wen 2004, Bo Wen 2004).[6]

Paragroup N-LLY22g* also has been found in samples of Han Chinese, but with widely varying frequency:

Other populations in which representatives of N1 * have been found include:

N1(xN1a, N1c) was found in ancient bones of Liao civilization:[7]

N1a (F1206/M2013/S11466)[edit]

The N1a2-F1008/L666 clade and N1a1-M46/Page70/Tat are estimated to share a most recent common ancestor in N1a-F1206/M2013/S11466 approximately 15,600 [95% CI 13,900 <-> 17,400] years before present[1] or 17,621 [95% CI 14,952 <-> 20,282] years before present.[8]

N1a1 (M46/Page70/Tat, L395/M2080)[edit]

The mutations that define the subclade N-M46[Phylogenetics 2] are M46/Tat and P105. This is the most frequent subclade of N. It arose probably in the region of present-day China, and subsequently experienced serial bottlenecks in Siberia and secondary expansions in eastern Europe (Rootsi 2006). Haplogroup N-M46 is approximately 14,000 years old.

In Siberia, haplogroup N-M46 reaches a maximum frequency of approximately 90% among the Yakuts, a Turkic people who live mainly in the Sakha (Yakutia) Republic. However, N-M46 is absent or present with much lower frequency among many of the Yakuts' neighbors, such as Evenks and Evens.[9] It also has been detected in 5.9% (3/51) of a sample of Hmong Daw from Laos (Cai 2011), 2.4% (2/85) of a sample from Seoul, South Korea (Katoh 2004), and in 1.4% (1/70) of a sample from Tokushima, Japan (Hammer 2005).

The haplogroup N-M46 has a low diversity among Yakuts suggestive of a population bottleneck or founder effect ( & Pakendorf 2002). This was confirmed by a study of ancient DNA which traced the origins of the male Yakut lineages to a small group of horse-riders from the Cis-Baikal area (Crubézy 2010).

N1a1a (M178)[edit]

The subclade N-M178[Phylogenetics 3] is defined by the presence of markers M178 and P298. N-M178* has higher average frequency in Northern Europe than in Siberia, reaching frequencies of approximately 60% among Finns and approximately 40% among Latvians, Lithuanians & 35% among Estonians (Derenko 2007 and Lappalainen 2008).

Miroslava Derenko and her colleagues noted that there are two subclusters within this haplogroup, both present in Siberia and Northern Europe, with different histories. The one that they labelled N3a1 first expanded in south Siberia (approximately 10,000 years ago on their calculated by the Zhivotovsky method) and spread into Northern Europe where its age they calculated as around 8,000 years ago. Meanwhile, the younger subcluster, which they labelled N3a2, originated in south Siberia (probably in the Baikal region) approximately 4,000 years ago (Derenko 2007).

N1a2 (F1008/L666)[edit]

N1a2a-M128 and N1a2b-B523/P43 are estimated to share a most recent common ancestor in N1a2-F1008/L666 approximately 9,000 [95% CI 7,800 <-> 10,200] years before present[1] or 9,314 [95% CI 7,419 <-> 11,264] years before present.[8]

N1a2a-M128[edit]

Haplogroup N-M128
Possible place of origin Asia
Ancestor N1c2 (F1008/L666)
Defining mutations M128

This subclade is defined by the presence of the marker M128.[Phylogenetics 4] N-M128 was first identified in a sample from Japan (1/23 = 4.3%) and in a sample from Central Asia and Siberia (1/184 = 0.5%) in a preliminary survey of worldwide Y-DNA variation.[10] Subsequently, it has been found with low frequency in some samples of the Manchu people, Sibe people, Evenks, Koreans, Han Chinese, Hui, Tibetans, Vietnamese, Bouyei people, Kazakhs, Uzbeks, Khakas, and Komis.[11]

A number of Han Chinese, an Ooled Mongol, a Qiang, and a Tibetan were found to belong to a sister branch (or branches) of N-M128 under paragroup N-F1154*.[12]

N1a2b (P43)[edit]

Haplogroup N-P43[Phylogenetics 5] is defined by the presence of the marker P43. It is a significantly younger[compared to?] subclade, perhaps only 6,000 to 8,000 years old, with a probable origin in Siberia (Derenko 2007). It is found frequently among Northern Samoyedic peoples; also found at low to moderate frequency among some other Uralic peoples, Turkic peoples, Mongolic peoples, Tungusic peoples, and Siberian Yupik people.

The highest frequencies of N-P43 are observed among north-west Siberian populations: 92% in the Nganassan, 78% in the Enets and 74% in the Tundra Nenets. In Europe, the N-P43 types have their highest frequency of 20% among Volga-Uralic populations. The extreme western border of the spread of N-P43 is Finland, where this haplogroup occurs only at marginal frequency – 0.4%. Yet interestingly, N-P43 is quite frequent among Vepsas (17.9%), a small Finnic population living in immediate proximity to Finns, Karelians and Estonians.[13]

Haplogroup N-P43 forms two distinctive subclusters of STR haplotypes, Asian and European, the latter mostly distributed among Uralic-speaking peoples and related populations (Rootsi 2006).

N1b (F2930)[edit]

Haplogroup N1b has been predominantly found in populations of southwestern China.[14] However, it also has been found in people all over China as well as in Poland, India, Bhutan, Japan, Vietnam, and Cambodia.

Phylogenetics[edit]

Phylogenetic history[edit]

Prior to 2002, there were in academic literature at least seven naming systems for the Y-Chromosome Phylogenetic tree. This led to considerable confusion. In 2002, the major research groups came together and formed the Y-Chromosome Consortium (YCC). They published a joint paper that created a single new tree that all agreed to use. Later, a group of citizen scientists with an interest in population genetics and genetic genealogy formed a working group to create an amateur tree aiming at being above all timely. The table below brings together all of these works at the point of the landmark 2002 YCC Tree. This allows a researcher reviewing older published literature to quickly move between nomenclatures.

YCC 2002/2008 (Shorthand) (α) (β) (γ) (δ) (ε) (ζ) (η) YCC 2002 (Longhand) YCC 2005 (Longhand) YCC 2008 (Longhand) YCC 2010r (Longhand) ISOGG 2006 ISOGG 2007 ISOGG 2008 ISOGG 2009 ISOGG 2010 ISOGG 2011 ISOGG 2012
N-LLY22g 12 VIII 1U 25 Eu16 H5 F N* N N1 N1 - - - - - - -
N-M128 12 VIII 1U 25 Eu16 H5 F N1 N1 N1a N1a - - - - - - -
N-P63 12 VIII 1U 25 Eu16 H5 F N2 N2a N1b1 N1b1 - - - - - - -
N-TAT 12 VIII 1I 26 Eu13 H5 F N3* N3 N1c N1c - - - - - - -
N-M178 16 VIII 1I 26 Eu14 H5 F N3a* M178 N1c1 N1c1 - - - - - - -
N-P21 16 VIII 1I 26 Eu14 H5 F N3a1 N3a1 N1c1a N1c1a - - - - - - -

Original research publications[edit]

The following research teams per their publications were represented in the creation of the YCC Tree.

Associated mutations (SNPs and UEPs)[edit]

B1/B3 The b2/b3 deletion in the AZFc region of the Y-chromosome. This deletion appears to have occurred independently on at least four different occasions. Therefore, this deletion should not be taken as a unique event polymorphism defining this branch of the Y-chromosome tree (ISOGG 2012).

Phylogenetic trees[edit]

Tree[edit]

In the following tree the nomenclature of 3 sources is separated by slashes: ISOGG Tree 10 December 2017 (ver.12.317)

  • NO-M214
    • N M231/Page91, M232/M2188     
      • N1-Z4762/CTS11499/L735/M2291
        • N1a-L729
          • N1a1-M46/Page70/Tat
            • N1a1a-M178
              • N1a1a2-Y23747
              • N1a1a1-F1419
                • N-Y24317
                  • N-Y24317*(xB187)
                  • N1a1a1b-B187
                • N1a1a1a-L708 
                  • N1a1a1a2-B211
                  • N1a1a1a1-P298
                    • N1a1a1a1b-M2118
                      • N1a1a1a1b-M2118*
                      • N1a1a1a1b1-M1982
                      • N1a1a1a1b2-A9408
                    • N1a1a1a1a-L392
                      • N1a1a1a1a1-CTS10760
                        • N1a1a1a1a1c-B479
                        • N1a1a1a1a1b-PH1266/Y28526/F4134
                        • N1a1a1a1a1a-CTS2929/VL29
                          • N1a1a1a1a1a1-Z4908
                            • N1a1a1a1a1a1a-L550/S431
                              • N1a1a1a1a1a1a1-B215/L1025
                          • N1a1a1a1a1a2-CTS9976
                      • N1a1a1a1a2-Z1936,CTS10082  
                        • N1a1a1a1a2a-Z1928/CTS2733
                          • N-YP6092
                            • N-B195
                          • N1a1a1a1a2a-Z1925
                            • N-Z1925*
                            • N-Y29767
                            • N1a1a1a1a2a2a1a1-Z1926 
                          • N1a1a1a1a2a1c-PH3340/Y13850
                            • N1a1a1a1a2a1c1-L1034
                              • N-Y28538
                              • N-L1442
                            • N1a1a1a1a2a1c2-Y24361
                      • N1a1a1a1a3-B197/Y16323
                        • N1a1a1a1a3a-F4205
                        • N1a1a1a1a3b-B202
          • N1a2-F1008/L666
            • N1a2a-M128
              • N1a2a1-F710
            • N1a2b-B523(P43)
        • N1b-F2905
          • N1b*-F2905
          • N1b1-CTS582
          • N1b2-M1819
      • N2-Y6503

Genetics[edit]

Y-DNA N subclades[edit]

  • N-M231

Y-DNA backbone tree[edit]

Phylogenetic tree of human Y-chromosome DNA haplogroups [χ 1][χ 2]
"Y-chromosomal Adam"
A00 A0-T [χ 3]
A0 A1 [χ 4]
A1a A1b
A1b1 BT
B CT
DE CF
D E C F
F1  F2  F3  GHIJK
G HIJK
IJK H
IJ K
I   J     LT [χ 5]       K2 [χ 6]
L     T    K2a [χ 7]        K2b [χ 8]     K2c     K2d K2e [χ 9]  
K-M2313     K2b1 [χ 10] P [χ 11]
NO   S [χ 12]  M [χ 13]    P1     P2
N O Q R

References[edit]

Footnotes[edit]

Work cited[edit]

  1. ^ a b c d e YFull Haplogroup YTree v5.04 at 16 May 2017
  2. ^ a b c Karmin, Monika; Saag, Lauri; Vicente, Mário; et al. (2015). "A recent bottleneck of Y chromosome diversity coincides with a global change in culture". Genome Research. 25 (4): 459–466. doi:10.1101/gr.186684.114. 
  3. ^ a b c Shi, H; Qi, X; Zhong, H; Peng, Y; Zhang, X; et al. (2013). "Genetic Evidence of an East Asian Origin and Paleolithic Northward Migration of Y-chromosome Haplogroup N". PLoS ONE. 8 (6): e66102. Bibcode:2013PLoSO...866102S. doi:10.1371/journal.pone.0066102. PMC 3688714Freely accessible. PMID 23840409. 
  4. ^ a b c d ISOGG, 2016, Y-DNA Haplogroup N and its Subclades – 2016 22 August 2016).
  5. ^ (Rootsi 2006)
  6. ^ Bo Wen 2004, Analyses of Genetic Structure of Tibeto-Burman Populations Reveals Sex-Biased Admixture in Southern Tibeto-Burmans
  7. ^ Yinqiu Cui, Hongjie Li, Chao Ning, Ye Zhang, Lu Chen, Xin Zhao, Erika Hagelberg and Hui Zhou (2013)"Y Chromosome analysis of prehistoric human populations in the West Liao River Valley, Northeast China. " BMC 13:216
  8. ^ a b Cite error: The named reference Ilumae2016 was invoked but never defined (see the help page).
  9. ^ Duggan, AT; Whitten, M; Wiebe, V; Crawford, M; Butthof, A; et al. (2013). "Investigating the Prehistory of Tungusic Peoples of Siberia and the Amur-Ussuri Region with Complete mtDNA Genome Sequences and Y-chromosomal Markers". PLoS ONE. 8 (12): e83570. Bibcode:2013PLoSO...883570D. doi:10.1371/journal.pone.0083570. 
  10. ^ Peter A. Underhill, Peidong Shen, Alice A. Lin et al., "Y chromosome sequence variation and the history of human populations," Nature Genetics • Volume 26 • November 2000
  11. ^ Siiri Rootsi, Lev A Zhivotovsky, Marian Baldovič, et al., "A counter-clockwise northern route of the Y-chromosome haplogroup N from Southeast Asia towards Europe." European Journal of Human Genetics (2007) 15, 204–211. doi:10.1038/sj.ejhg.5201748; published online 6 December 2006.
  12. ^ Kang Hu (2015)
  13. ^ https://www.nature.com/ejhg/journal/v15/n2/full/5201748a.html
  14. ^ Hu, et al. 2015. The dichotomy structure of Y chromosome Haplogroup N. arXiv:1504.06463

Journals

Websites

Further reading[edit]

Phylogenetics[edit]

  1. ^ The b2/b3 deletion in the AZFc region of the human Y-chromosome is a characteristic of Haplogroup N-M231 haplotypes. This deletion, however, appears to have occurred independently on four different occasions. Therefore this deletion should not be thought as a unique event polymorphism contributing to the definition of this branch of the Y-chromosome tree (ISOGG 2012).
  2. ^ This table shows historic names for N-M46 (AKA N-Tat) from peer reviewed literature.
    YCC 2002/2008 (Shorthand) N-M46/N-TAT
    Jobling and Tyler-Smith 2000 12
    Underhill 2000 VIII
    Hammer 2001 1I
    Karafet 2001 26
    Semino 2000 Eu13
    Su 1999 H5
    Capelli 2001 F
    YCC 2002 (Longhand) N3*
    YCC 2005 (Longhand) N3
    YCC 2008 (Longhand) N1c
    YCC 2010r (Longhand) N1c
  3. ^ This table shows historic names for N-M178 from peer reviewed literature.
    YCC 2002/2008 (Shorthand) N-M178
    Jobling and Tyler-Smith 2000 16
    Underhill 2000 VIII
    Hammer 2001 1I
    Karafet 2001 26
    Semino 2000 Eu14
    Su 1999 H5
    Capelli 2001 F
    YCC 2002 (Longhand) N3a*
    YCC 2005 (Longhand) M178
    YCC 2008 (Longhand) N1c1
    YCC 2010r (Longhand) N1c1
  4. ^ This table shows historic names for N-M128 from peer reviewed literature.
    YCC 2002/2008 (Shorthand) N-M128
    Jobling and Tyler-Smith 2000 12
    Underhill 2000 VIII
    Hammer 2001 1U
    Karafet 2001 25
    Semino 2000 Eu16
    Su 1999 H5
    Capelli 2001 F
    YCC 2002 (Longhand) N1
    YCC 2005 (Longhand) N1
    YCC 2008 (Longhand) N1a
    YCC 2010r (Longhand) N1a
  5. ^ This branch is sometimes called N1b in early trees.

External links[edit]