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Hemopexin

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This article is about the hemopexin protein. For the family of proteins containing hemopexin-like repeats, see hemopexin family.

Template:PBB Hemopexin (or haemopexin; HPX), also known as beta-1B-glycoprotein is a protein that in humans is encoded by the HPX gene[1][2][3] and belongs to hemopexin family of proteins.[4]

Function

Hemopexin binds heme with the highest affinity of any known protein. Its function is scavenging the heme released or lost by the turnover of heme proteins such as hemoglobin and thus protects the body from the oxidative damage that free heme can cause. In addition, hemopexin releases its bound ligand for internalisation upon interacting with a specific receptor situated on the surface of liver cells. This function of hemopexin is to preserve the body's iron.[5]

Clinical significance

Its levels in serum reflect how much heme is present in the blood. Therefore, low hemopexin levels indicates that there has been significant degradation of heme containing compounds and hemopexin is made to scavenge any heme it can. Low hemopexin levels are one of the diagnostic features of an intravascular hemolytic anemia.[6]

References

  1. ^ "Entrez Gene: HPX hemopexin".
  2. ^ Altruda F, Poli V, Restagno G, Silengo L (1988). "Structure of the human hemopexin gene and evidence for intron-mediated evolution". J. Mol. Evol. 27 (2): 102–8. doi:10.1007/BF02138368. PMID 2842511.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  3. ^ Altruda F, Poli V, Restagno G, Argos P, Cortese R, Silengo L (June 1985). "The primary structure of human hemopexin deduced from cDNA sequence: evidence for internal, repeating homology". Nucleic Acids Res. 13 (11): 3841–59. doi:10.1093/nar/13.11.3841. PMC 341281. PMID 2989777.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  4. ^ Bode W (June 1995). "A helping hand for collagenases: the haemopexin-like domain". Structure. 3 (6): 527–30. doi:10.1016/s0969-2126(01)00185-x. PMID 8590012.
  5. ^ Tolosano E, Altruda F (April 2002). "Hemopexin: structure, function, and regulation". DNA Cell Biol. 21 (4): 297–306. doi:10.1089/104454902753759717. PMID 12042069.
  6. ^ Hoffbrand, A.V.; Moss, P.A.H.; Pettit, J.E. (2006). Essential Haematology (5th ed.). Oxford: Blackwell Publishing. p. 60. ISBN 978-1-4051-3649-5.

Further reading

Template:PBB Further reading

See also

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