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In February 2004, Losco released her first-ever E.P. "Love me or Hate me>Who I Am". On 19 April 2004, she released her first studio album "Someone Else". The album boasted international song writers and Losco's first Anthem "Love Me or Hate Me" which quickly became a Maltese dance floor hit. On 28 June 2004, she launched her second music video (after 7th Wonder) for the track "I'm In Love Again". Her third album, named Accident Prone, was released on 16 November 2005. It topped the charts on the island and won a BMA for the Best Song that year. Out of the 9 tracks, "Everyday", "Get Out!", "Don't Wanna Talk About It", "Driving One Of Your Cars", "Accident Prone", "Uh-Oh", and "Waking Up To The Light", were released as singles. All of them received great airplay by local stations, particularly "Accident Prone" and "Uh-Oh".
Tracks written by Losco/Debono and international writers have made their way to Michelle Hunziker's album 'Lole'. These tracks were 'Someone Else', 'Get Out', 'I'm in Love Again.' The prominent guitar riff on 'Uh-Oh' was included in Kelly Clarkson's hit "Don't Waste Your Time".Unmasked is Losco's unplugged album, including acoustic versions of some of her tracks. In July 2007, Losco released her single entitled "Something To Talk About" from her third studio album Fortune Teller, which was released on 11 June 2008. It stayed number one for four weeks in the local charts.
On 10 December 2007, "Living It..." was released in local cinemas and on DVD. It includes memorable live performances, international collaborations, videos, never seen before backstage footage, a personal interview and exclusive new tracks off the album. Losco's second remix album, called Mixed Beats, was launched in Malta on 22 August 2009. This remix album contains remixes of tracks from Losco's previous albums. After the release of the single "What I'd Give" in August 2012, Losco released her fourth album in March 2013.