NAIP (gene)

NAIP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2VM5
Identifiers
Aliases	NAIP, BIRC1, NLRB1, psiNLR family, apoptosis inhibitory protein, NLR family apoptosis inhibitory protein
External IDs	OMIM: 600355 MGI: 1298226 HomoloGene: 136092 GeneCards: NAIP
Gene location (Human)
Chr.	Chromosome 5 (human)
End	71,025,339 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	100,338,600 bp
RNA expression pattern
	Top expressed in
	monocyte; ; spleen; ; appendix; ; bone marrow cells; ; right uterine tube; ; ganglionic eminence; ; right lung; ; blood; ; upper lobe of left lung; ; left lobe of thyroid gland;
	Top expressed in
	left colon; ; ileum; ; Paneth cell; ; jejunum; ; intestinal villus; ; duodenum; ; urethra; ; male urethra; ; parotid gland; ; pyloric antrum;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase inhibitor activity; nucleotide binding; cysteine-type endopeptidase inhibitor activity; metal ion binding; ubiquitin-protein transferase activity; protein binding; ATP binding; cysteine-type endopeptidase inhibitor activity involved in apoptotic process;
Cellular component	perikaryon; neuronal cell body; basolateral plasma membrane; neuron projection; cytoplasm; nucleus;
Biological process	negative regulation of neuron apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; response to amino acid; negative regulation of peptidase activity; immune system process; nervous system development; response to axon injury; innate immune response; inflammatory response; apoptotic process; protein ubiquitination; positive regulation of canonical Wnt signaling pathway; mitotic spindle assembly; inhibition of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	4671
	17948
	ENSG00000278613; ENSG00000276068; ENSG00000249437
	ENSMUSG00000078945
	Q13075
	Q9QUK4
	NM_004536; NM_022892; NM_001346870
	NM_001126182; NM_010872
	NP_001333799; NP_004527; NP_075043
	NP_001119654; NP_035002
	Wikidata
View/Edit Human	View/Edit Mouse

Baculoviral IAP repeat-containing protein 1 is a protein that in humans is encoded by the NAIP gene.^[5]^[6]

Template:PBB Summary

References

^ ^a ^b ^c ENSG00000276068, ENSG00000249437 GRCh38: Ensembl release 89: ENSG00000278613, ENSG00000276068, ENSG00000249437 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000078945 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Roy N, Mahadevan MS, McLean M, Shutler G, Yaraghi Z, Farahani R, Baird S, Besner-Johnston A, Lefebvre C, Kang X, et al. (Feb 1995). "The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy". Cell. 80 (1): 167–78. doi:10.1016/0092-8674(95)90461-1. PMID 7813013.
^ "Entrez Gene: NAIP NLR family, apoptosis inhibitory protein".

External links

Neuronal+Apoptosis-Inhibitory+Protein at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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[refGRCh38Ensembl-1] ENSG00000276068, ENSG00000249437 GRCh38: Ensembl release 89: ENSG00000278613, ENSG00000276068, ENSG00000249437 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000078945 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7813013-5] Roy N, Mahadevan MS, McLean M, Shutler G, Yaraghi Z, Farahani R, Baird S, Besner-Johnston A, Lefebvre C, Kang X, et al. (Feb 1995). "The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy". Cell. 80 (1): 167–78. doi:10.1016/0092-8674(95)90461-1. PMID 7813013.

[entrez-6] "Entrez Gene: NAIP NLR family, apoptosis inhibitory protein".

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[5]

[6]

v t e NOD-like receptor family
CARD domain containing	NOD1/NLRC1 NOD2/NLRC2 NLRC3 NLRC4 NLRC5
Pyrin domain containing	NLRP1 NLRP2 NLRP3 NLRP4 NLRP5 NLRP6 NLRP7 NLRP8 NLRP9 NLRP10 NLRP11 NLRP12 NLRP13 NLRP14
Apoptosis inhibitory protein	NAIP
Family member X1	NLRX1

References

Further reading

External links