Very-long-chain 3-oxoacyl-CoA reductase
| Very-long-chain 3-oxoacyl-CoA reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.330 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Very-long-chain 3-oxoacyl-CoA reductase (EC 1.1.1.330, very-long-chain 3-ketoacyl-CoA reductase, very-long-chain beta-ketoacyl-CoA reductase, KCR (gene), IFA38 (gene)) is an enzyme with systematic name (3R)-3-hydroxyacyl-CoA:NADP+ oxidoreductase.[1][2][3] This enzyme catalyses the following chemical reaction
- a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP+ a very-long-chain 3-oxoacyl-CoA + NADPH + H+
This microsomal complex extendins palmitoyl-CoA and stearoyl-CoA (and their modified forms) to very-long-chain acyl CoAs.
References
- ^ Beaudoin, F.; Gable, K.; Sayanova, O.; Dunn, T.; Napier, J.A. (2002). "A Saccharomyces cerevisiae gene required for heterologous fatty acid elongase activity encodes a microsomal β-keto-reductase". J. Biol. Chem. 277 (13): 11481–11488. doi:10.1074/jbc.M111441200. PMID 11792704.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Han, G.; Gable, K.; Kohlwein, S.D.; Beaudoin, F.; Napier, J.A.; Dunn, T.M. (2002). "The Saccharomyces cerevisiae YBR159w gene encodes the 3-ketoreductase of the microsomal fatty acid elongase". J. Biol. Chem. 277 (38): 35440–35449. doi:10.1074/jbc.M205620200. PMID 12087109.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Beaudoin, F.; Wu, X.; Li, F.; Haslam, R.P.; Markham, J.E.; Zheng, H.; Napier, J.A.; Kunst, L. (2009). "Functional characterization of the Arabidopsis β-ketoacyl-coenzyme A reductase candidates of the fatty acid elongase". Plant Physiol. 150 (3): 1174–1191. doi:10.1104/pp.109.137497. PMC 2705042. PMID 19439572.
External links
- Very-long-chain+3-oxoacyl-CoA+reductase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)