Amodiaquine

Amodiaquine

Systematic (IUPAC) name
4-[(7-chloroquinolin-4-yl)amino]-2-[(diethylamino)methyl]phenol
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	?
Pharmacokinetic data
Half-life	5.2 ± 1.7 (range 0.4 to 5.5) minutes
Identifiers
CAS number	86-42-0 Y
ATC code	P01BA06
PubChem	CID 2165
DrugBank	APRD00796
ChemSpider	2080 Y
UNII	220236ED28 Y
KEGG	D02922 Y
ChEBI	CHEBI:2674 Y
ChEMBL	CHEMBL682 Y
Chemical data
Formula	C20H22ClN3O
Mol. mass	355.861 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C20H22ClN3O/c1-3-24(4-2)13-14-11-16(6-8-20(14)25)23-18-9-10-22-19-12-15(21)5-7-17(18)19/h5-12,25H,3-4,13H2,1-2H3,(H,22,23) Y Key:OVCDSSHSILBFBN-UHFFFAOYSA-N Y
N(what is this?)  (verify)

Amodiaquine (trade names Camoquin, Flavoquine) is a 4-aminoquinoline compound related to chloroquine, used as an antimalarial and anti-inflammatory agent.

Amodiaquine has been shown to be more effective than chloroquine in treating CRPF (chloroquine-resistant Plasmodium falciparum) malaria infections and may afford more protection than chloroquine when used as weekly prophylaxis. Amodiaquine, like chloroquine, is generally well tolerated. Although licensed, this drug is not marketed in the United States but is widely available in Africa. Its use, therefore, is probably more practicable in long-term visitors and persons who will reside in Africa.

Amodiaquine is a histamine N-methyltransferase inhibitor.