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D-Deprenyl, also known as or dextro-N-propargyl-N-methylamphetamine, is an MAO-B inhibitor that metabolizes into D-amphetamine and D-methamphetamine, and therefore a norepinephrine-dopamine releasing agent. It is the opposite enantiomer of L-deprenyl (selegiline).
L-Deprenyl, also an MAO-B inhibitor, metabolizes to L-amphetamine and l-methamphetamine, which are both monoamine releasing agents. In contrast, D-deprenyl additionally has dopaminergic effects and has been found to be reinforcing in scientific research, whereas L-Deprenyl is not know to have any appreciable psychological reinforcement.[dubious ]
- Selegiline (L-Deprenyl)
- Yasar S; Gaál J; Panlilio LV et al. (January 2006). "A comparison of drug-seeking behavior maintained by d-amphetamine, l-deprenyl (selegiline) and d-deprenyl under a second-order schedule in squirrel monkeys". Psychopharmacology 183 (4): 413–21. doi:10.1007/s00213-005-0200-7. PMC 1360227. PMID 16292593.
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