Pancuronium bromide

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Pancuronium
Pancuronium.svg
Pancuronium-3D-sticks.png
Systematic (IUPAC) name
[(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-
17-acetyloxy-10,13-dimethyl-2,16-bis(1-methyl-
3,4,5,6-tetrahydro-2H-pyridin-1-yl)-2,3,4,5,6,7,
8,9,11,12,14,15,16,17-tetradecahydro-1H-
cyclopenta[a]phenanthren-3-yl] acetate
Clinical data
AHFS/Drugs.com monograph
Pregnancy cat.
Legal status
Routes Intravenous
Pharmacokinetic data
Bioavailability NA
Protein binding 77 to 91%
Metabolism Hepatic
Half-life 1.5 to 2.7 hours
Excretion Renal and biliary
Identifiers
CAS number 16974-53-1 YesY
15500-66-0 (bromide)
ATC code M03AC01
PubChem CID 441289
IUPHAR ligand 4001
DrugBank DB01337
ChemSpider 25453 N
UNII U9LY9Y75X2 N
KEGG D00492 YesY
ChEBI CHEBI:7908 N
ChEMBL CHEMBL185073 N
Chemical data
Formula C35H60N2O4 
Mol. mass 572.861 g/mol
 N (what is this?)  (verify)

Pancuronium (trademarked as Pavulon) is a muscle relaxant with various purposes. It is the second of three drugs administered during most lethal injections in the United States.

Mechanism of action[edit]

Pancuronium is a typical non-depolarizing curare-mimetic muscle relaxant. It acts as a competitive acetylcholine antagonist on neuromuscular junctions, displacing acetylcholine (hence competitive) from its post-synaptic nicotinic acetylcholine receptors. It is (unlike suxamethonium) a non-depolarizing agent, which means that it causes no spontaneous depolarizations upon association with the nicotinic receptor in neuromuscular junction, thus producing no muscle fasciculations upon administration. Despite being a steroid, pancuronium has no hormonal activity. It exerts slight vagolytic activity (i.e. diminishing activity of the vagus nerve) and no ganglioplegic (i.e. blocking ganglions) activity. Pancuronium is a very potent muscle relaxant/curaremimetic. The ED95 (i.e. the dose that causes 95% depression of muscle twitch response) is only 60 µg/kg body weight administered intravenously. Muscle relaxation suitable for intubation sets in about 90–120 seconds after administration of the drug. Full muscle paralysis for major surgery is achieved about 2–4 minutes after application. Clinical effects (muscle activity lower than 25% of physiological) last for about 100 minutes. The time needed for full (over 90% muscle activity) recovery after single administration is about 120–180 minutes in healthy adults, but can be protracted to more hours in poor health subjects and when concomitantly administered with other long-acting anesthetics (e.g., some opioids, barbiturates, inhalation anesthetics). The effects of pancuronium can be at least partially reversed by anticholinesterasics, such as neostigmine, pyridostigmine, and edrophonium.

Development[edit]

Pancuronium is designed to mimic the action of two molecules of acetylcholine with the quaternary nitrogen atoms spaced rigidly apart by the steroid rings at a distance of ten atoms (interonium distance). Decamethonium and suxamethonium also have this same interonium distance.

Uses in medicine[edit]

Pancuronium is used with general anaesthesia in surgery for muscle relaxation and as an aid to intubation or ventilation. It does not have sedative or analgesic effects.

Side-effects include moderately raised heart rate and thereby arterial pressure and cardiac output, excessive salivation, apnea and respiratory depression, rashes, flushing, and sweating. The muscular relaxation can be dangerous in the seriously ill and it can accumulate leading to extended weakness. Pancuronium is not preferable in long-term use in ICU-ventilated patients.

In Belgium and the Netherlands, pancuronium is recommended in the protocol for euthanasia. After administering sodium thiopental to induce coma, pancuronium is delivered in order to stop breathing.[1]

In 2007, Dr Michael Munro, a Scottish neonatologist at Aberdeen Maternity Hospital, was cleared of malpractice by the GMC Fitness to Practice panel after giving 23 times the standard dose of pancuronium to two dying neonates. In the final minutes of life, each baby was suffering from agonal gasping and violent body spasms, which was highly distressing for the parents to witness. Dr Munro then administered pancuronium to the babies after advising the parents that this would ease their suffering, but could also hasten death.[2][3] It is on record that neither of the children's parents was unhappy with Dr Munro's treatment of their babies.[4]

Uses in execution[edit]

Procedure[edit]

It is also used as one component of a lethal injection in administration of the death penalty in some parts of the United States.[5]

Controversy[edit]

Pancuronium bromide has no hypnotic effects, and, if the anaesthetic agent used in lethal injection is ineffective, the individual may never achieve unconsciousness, and thus be able to feel all of the pain associated with the procedure, but unable to cry out or move due to the pancuronium's complete paralytic action. There have also been several high-profile civil lawsuits alleging similar failures to achieve analgesia or unconsciousness prior to general surgical procedures. These, too, have been blamed largely on improper or insufficient dosages of anaesthetic in concert with normal dosages of pancuronium bromide.

Echoing this sentiment, Amnesty International has objected to its use in lethal injections on the grounds that it "may mask the condemned prisoner's suffering during the execution,"[6] thereby leading observers to conclude that lethal injection is painless, or less cruel than other forms of execution.

In September 2007, the US Supreme Court agreed to hear their first case of whether or not the use of lethal injection does in fact violate the US Constitution's Eighth Amendment's ban on cruel and unusual punishment.[7] On April 16, 2008, the court upheld the constitutionality of Kentucky's lethal injection practices.[8]

Uses in crime[edit]

Pancuronium is the compound that was used in Efren Saldivar's killing spree.[9] It was also used by the Skin Hunters to kill patients in the Polish city of Łódź. Pavulon was also used by Richard Angelo in 1987 to kill at least 10 patients under his care at the Good Samaritan Hospital in New York.

References[edit]

  1. ^ "Administration and Compounding Of Euthanasic Agents". Retrieved 15 July 2008. 
  2. ^ "Baby doctor cleared of misconduct". BBC News. 2007-07-11. Retrieved 2010-05-21. 
  3. ^ "Doctor cleared over baby deaths". The Guardian. 11 July 2007. 
  4. ^ "Doctor felt babies were suffering". BBC News. 2007-07-09. Retrieved 2010-05-21. 
  5. ^ BBC article on lethal injection. Small panel lists the chemicals used.
  6. ^ Amnesty International
  7. ^ "Court to decide lethal injection, voter ID cases". CNN. 2007. Archived from the original on 2008-01-12. Retrieved 2007-09-25. 
  8. ^ "US Supreme Court published opinions" (PDF). US Supreme Court. 2008. 
  9. ^ Crimelibrary

External links[edit]