A-84,543

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A-84,543
A-84543 structure.png
Systematic (IUPAC) name
3-(1-methyl-2-(S)-pyrrolidinylmethoxy)pyridine
Clinical data
Legal status
?
Identifiers
CAS number  YesY
ATC code ?
PubChem CID 178052
ChemSpider 155000 YesY
ChEMBL CHEMBL127071 YesY
Chemical data
Formula C11H16N2O 
Mol. mass 192.257
 YesY (what is this?)  (verify)

A-84543 is a drug developed by Abbott, which acts as an agonist at neural nicotinic acetylcholine receptors with high selectivity for the α4β2 subtype. It is widely used in scientific research into the structure and function of this receptor subtype and has been the lead compound for the development of a large family of related derivatives.[1][2][2][3][4]

References[edit]

  1. ^ Abreo, M.; Lin, N.; Garvey, D.; Gunn, D.; Hettinger, A.; Wasicak, J.; Pavlik, P.; Martin, Y.; Donnelly-Roberts, D.; Anderson, D. J.; Sullivan, J. P.; Williams, M.; Arneric, S. P.; Holladay, M. W. (1996). "Novel 3-Pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors". Journal of Medical Chemistry 39 (4): 817–825. doi:10.1021/jm9506884. PMID 8632405.  edit
  2. ^ a b Lin, N. H.; Gunn, D. E.; Li, Y.; He, Y.; Bai, H.; Ryther, K. B.; Kuntzweiler, T.; Donnelly-Roberts, D. L.; Anderson, D. J.; Campbell, J. E.; Sullivan, J. P.; Arneric, S. P.; Holladay, M. W. (1998). "Synthesis and structure-activity relationships of pyridine-modified analogs of 3-2-((S)-pyrrolidinyl)methoxypyridine, A-84543, a potent nicotinic acetylcholine receptor agonist". Bioorganic & Medicinal Chemistry Letters 8 (3): 249–254. doi:10.1016/S0960-894X(98)00019-5. PMID 9871663.  edit
  3. ^ Wei, Z.; Xiao, Y.; Yuan, H.; Baydyuk, M.; Petukhov, P.; Musachio, J.; Kellar, K.; Kozikowski, A. (2005). "Novel pyridyl ring C5 substituted analogues of epibatidine and 3-(1-methyl-2(S)-pyrrolidinylmethoxy)pyridine (A-84543) as highly selective agents for neuronal nicotinic acetylcholine receptors containing beta2 subunits". Journal of Medicinal Chemistry 48 (6): 1721–1724. doi:10.1021/jm0492406. PMID 15771418.  edit
  4. ^ Carreras, J.; Avenoza, A.; Busto, J.; Peregrina, J. (2007). "Synthesis of azabicyclo2.2.nalkane systems as analogues of 3-1-methyl-2-(S)-pyrrolidinyl- methoxypyridine (A-84543)". The Journal of Organic Chemistry 72 (8): 3112–3115. doi:10.1021/jo0700732. PMID 17371077.  edit