Quifenadine

Quifenadine
Clinical data
Trade names	Fencarol
Other names	3-quinuclidinyldiphenylmethanol
Routes of; administration	Oral (tablets), IM
ATC code	R06AX31 (WHO) ;
Legal status
Legal status	OTC (tablets), ℞-only (solution for IM injection) (RU);
Pharmacokinetic data
Bioavailability	45% (Tmax = 1 hour)
Metabolism	Hepatic
Identifiers
	IUPAC name 1-azabicyclo[2.2.2]octan-3-yl(diphenyl)methanol;
CAS Number	10447-38-8;
PubChem CID	65600;
ChemSpider	59041;
CompTox Dashboard (EPA)	DTXSID6046187 ;
Chemical and physical data
Formula	C20H23NO
Molar mass	293.40 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES OC(c1ccccc1)(c2ccccc2)C4C3CCN(CC3)C4;
	InChI InChI=1S/C20H23NO/c22-20(17-7-3-1-4-8-17,18-9-5-2-6-10-18)19-15-21-13-11-16(19)12-14-21/h1-10,16,19,22H,11-15H2; Key:PZMAHNDJABQWGS-UHFFFAOYSA-N;

Quifenadine (Russian: хифенадин, trade name: Phencarol, Фенкарол) is an 2nd generation antihistamine drug, marketed mainly in post-Soviet countries.^[2]^[3] Chemically, it is a quinuclidine derivative.

Indications

References

^ ^a ^b "Fencarol (quifenadine) Tablets, for Oral Use. Full Prescribing Information". State Register of Medicines (in Russian). Retrieved 4 January 2016.
^ "Quifenadine". Drugs.com. Retrieved 28 January 2014.
^ Makarov, L.; Balykova, L.; Soldatova, O.; Komolyatova, V.; Serebruany, V. (2010). "The antiarrhythmic properties of quifenadine, H1-histamine receptor blocker in children with premature beats: A randomized controlled pilot trial". American journal of therapeutics. 17 (4): 396–401. doi:10.1097/MJT.0b013e3181a86987. PMID 19487925.

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[PI-1] "Fencarol (quifenadine) Tablets, for Oral Use. Full Prescribing Information". State Register of Medicines (in Russian). Retrieved 4 January 2016.

[2] "Quifenadine". Drugs.com. Retrieved 28 January 2014.

[3] Makarov, L.; Balykova, L.; Soldatova, O.; Komolyatova, V.; Serebruany, V. (2010). "The antiarrhythmic properties of quifenadine, H1-histamine receptor blocker in children with premature beats: A randomized controlled pilot trial". American journal of therapeutics. 17 (4): 396–401. doi:10.1097/MJT.0b013e3181a86987. PMID 19487925.

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v t e Antihistamines (R06)
Benzimidazoles (*)	Astemizole Azelastine Bilastine Emedastine Mizolastine Talastine
Diarylmethanes	Diarylmethoxyalkylamines: Bromazine (bromodiphenhydramine) Carbinoxamine Chlorphenoxamine Clemastine Diphenhydramine (+naproxen) Diphenylpyraline Doxylamine Ebastine Orphenadrine Diphenylmethanolpiperidines: Fexofenadine Terfenadine Diphenylmethylpiperazines: Buclizine Cetirizine Levocetirizine Chlorcyclizine Cinnarizine Cyclizine Etodroxizine Hydroxyzine Meclizine Oxatomide Phenylpyridinylpropanamines: Brompheniramine Chlorphenamine Dexbrompheniramine (+pseudoephedrine) Dexchlorpheniramine (+betamethasone) Pheniramine Others: Acrivastine Bamipine Dimetindene Phenyltoloxamine Pyrrobutamine Quifenadine Triprolidine
Ethylenediamines	Antazoline Chloropyramine Histapyrrodine Mepyramine (pyrilamine) Methapyrilene Phenbenzamine Thenalidine Tripelennamine (pyribenzamine)
Tricyclics	Dibenzocycloheptenes: Antidepressants (e.g., amitriptyline) Azatadine Cyproheptadine Deptropine Desloratadine Ketotifen Loratadine Rupatadine Phenothiazines: Alimemazine Fenethazine Hydroxyethylpromethazine Isothipendyl Mequitazine Methdilazine Oxomemazine Promethazine Others: Antidepressants (e.g., doxepin, mirtazapine, trimipramine) Epinastine Latrepirdine Mebhydrolin Olopatadine Perlapine Phenindamine Pimethixene
Others	Phenylpiperazines: Antidepressants (e.g., trazodone) Phenbenzamine
For topical use	Bamipine Chloropyramine Chlorphenoxamine Clemastine Dimetindene Diphenhydramine Doxepin Isothipendyl Mepyramine (pyrilamine) Promethazine