Buclizine

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Buclizine
Buclizine.svg
Systematic (IUPAC) name
(RS)-1-[(4-chlorophenyl)- phenyl-methyl]-4- [(4-tert-butylphenyl) methyl] piperazine
Clinical data
AHFS/Drugs.com Micromedex Detailed Consumer Information
Legal status ?
Identifiers
CAS number 82-95-1 YesY
ATC code R06AE01
PubChem CID 6729
DrugBank DB00354
ChemSpider 6473 YesY
UNII 0C94V6X681 YesY
ChEBI CHEBI:3205 YesY
ChEMBL CHEMBL1201271 N
Chemical data
Formula C28H33ClN2 
Mol. mass 433.028 g/mol
 N (what is this?)  (verify)

Buclizine is an antihistamine and anticholinergic of the piperazine derivative family. It is considered to be an antiemetic, similar to meclizine.[1]

In the United Kingdom, buclizine is one of three drugs contained in Migraleve tablets, marketed by McNeil Healthcare at migraine sufferers.[2]

References[edit]

  1. ^ Mostafa, G. A. E.; Al-Badr, A. A. (2011). "Buclizine". Profiles of drug substances, excipients, and related methodology. Profiles of Drug Substances, Excipients and Related Methodology 36: 1–33. doi:10.1016/B978-0-12-387667-6.00001-4. ISBN 9780123876676. PMID 22469258.  edit
  2. ^ Behrendt, W. A.; Cserepes, J. (1985). "Acute toxicity and analgesic action of a combination of buclizine, codeine and paracetamol ('Migraleve') in tablet and suppository form in rats". Pharmatherapeutica 4 (5): 322–331. PMID 4070325.  edit