Epinastine

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Epinastine
Epinastine.svg
Systematic (IUPAC) name
(RS)-3-amino-9,13b-dihydro-1H-dibenz(c,f)imidazo(1,5-a)azepine
Clinical data
AHFS/Drugs.com monograph
MedlinePlus a604011
Pregnancy cat. C
Legal status ?
Routes Eye drops
Pharmacokinetic data
Protein binding 64%
Half-life 12 hours
Identifiers
CAS number 80012-43-7 YesY
ATC code R06AX24 S01GX10
PubChem CID 3241
DrugBank DB00751
ChemSpider 3128 YesY
UNII Q13WX941EF YesY
KEGG D07900 YesY
ChEBI CHEBI:51032 YesY
ChEMBL CHEMBL1106 YesY
Chemical data
Formula C16H15N3 
Mol. mass 249.311 g/mol
 YesY (what is this?)  (verify)

Epinastine (brand names Alesion, Elestat, Purivist, Relestat) is a second-generation antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis. It is produced by Allergan and marketed by Inspire in the United States.[1] It is highly selective for the H1 receptor and does not cross the blood-brain-barrier.[2]

References[edit]

  1. ^ Pradhan, S; Abhishek, K; Mah, F (2009). "Epinastine: topical ophthalmic second generation antihistamine without significant systemic side effects". Expert opinion on drug metabolism & toxicology 5 (9): 1135–40. doi:10.1517/17425250903117284. PMID 19630694. 
  2. ^ Walther G, Daniel H, Bechtel WD, Brandt K (April 1990). "New tetracyclic guanidine derivatives with H1-antihistaminic properties. Chemistry of epinastine". Arzneimittel-Forschung 40 (4): 440–6. PMID 1972625. 

External links[edit]