Desloratadine

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Desloratadine
Desloratadine.svg
Desloratadine2.png
Systematic (IUPAC) name
8-chloro-6,11-dihydro-11-(4-piperdinylidene)- 5H-benzo[5,6]cyclohepta[1,2-b]pyridine
Clinical data
Trade names Clarinex
AHFS/Drugs.com monograph
MedlinePlus a602002
Licence data EMA:Link, US FDA:link
  • AU: B1
  • US: C (Risk not ruled out)
oral
Pharmacokinetic data
Bioavailability Rapidly absorbed
Protein binding 85%
Metabolism Liver
Half-life 27 hours
Excretion 40% as conjugated metabolites into urine
Similar amount into the feces
Identifiers
100643-71-8 YesY
R06AX27
PubChem CID 124087
DrugBank DB00967 YesY
ChemSpider 110575 YesY
UNII FVF865388R YesY
KEGG D03693 YesY
ChEBI CHEBI:291342 YesY
ChEMBL CHEMBL1172 YesY
Chemical data
Formula C19H19ClN2
310.82
 YesY (what is this?)  (verify)

Desloratadine is a drug used to treat allergies. It is an active metabolite of loratadine.

Use[edit]

Desloratadine is used to treat allergic rhinitis and nasal congestion.[1] It is the major metabolite of loratadine and the two drugs are similar in safety and effectiveness.[1]

Side effects[edit]

Most common side-effects are fatigue, dry mouth, headache, and gastrointestinal disturbances.[1]

Mechanism of action[edit]

Desloratadine is a tricyclic antihistamine, which has a selective and peripheral H1-antagonist action. It is an antagonist at histamine H1 receptors, and an antagonist at all subtypes of the muscarinic acetylcholine receptors. It has a long-lasting effect and in moderate and low doses, does not cause drowsiness because it does not readily enter the central nervous system.[2]

Society and culture[edit]

Desloratadine is available in many dosage forms and under many trade names worldwide.[3]

References[edit]

  1. ^ a b c See S (2003). "Desloratadine for allergic rhinitis". Am Fam Physician 68 (10): 2015–6. PMID 14655812. 
  2. ^ Mann R, Pearce G, Dunn N, Shakir S (2000). "Sedation with "non-sedating" antihistamines: four prescription-event monitoring studies in general practice". BMJ 320 (7243): 1184–6. doi:10.1136/bmj.320.7243.1184. PMC 27362. PMID 10784544. 
  3. ^ Drugs.com Desloratadine entry at drugs.com international Page accessed May 4, 2015