The campaign classification established by the United StatesNational Park Service is more fine-grained than the one used in this article. Some minor NPS campaigns have been omitted and some have been combined into larger categories. Only a few of the 75 battles the NPS classifies for this theater are described. Boxed text in the right margin show the NPS campaigns associated with each section.
The Battle of Glorieta Pass was a small skirmish in terms of both numbers involved and losses (140 Union, 190 Confederate). Yet the issues were large, and the battle was decisive in resolving them. The Confederates might well have taken Fort Union and Denver had they not been stopped at Glorieta. As one Texan put it, "If it had not been for those devils from Pike's Peak, this country would have been ours."
This small battle dissolved any possibility of the Confederacy taking New Mexico and the far west territories. In April, the California Column, Union volunteers from California, pushed the remaining Confederates out of present-day Arizona at the Battle of Picacho Pass. In the Eastern United States, the fighting dragged on for three more years, but in the Southwest the war against the Confederacy was over, but the war against the Apache, Navaho and Comanche continued for the California garrisons until they were replaced by U. S. Army troops after the Civil War ended.
Several battles occurred between Confederate soldiers and or militia within Confederate Arizona, the height of the Apache campaigns against rebel forces was during mid to late 1861.
Though a slave state with a highly organized and militant secessionist movement, thanks to the pro-slavery "border ruffians" who battled antislavery militias in Kansas in the 1850s, Missourians sided with the Union by a ratio of two or three to one. Pro-Confederate Governor Claiborne F. Jackson and his small state guard under General Sterling Price linked up with Confederate forces under General Ben McCulloch. After victories at the Battle of Wilson's Creek and at Lexington, Missouri, Confederate forces were driven out of the state by the arrival of large Union forces in February 1862 and were effectively locked out by defeat at the Battle of Pea Ridge, Arkansas, on March 7 and March 8.
A guerrilla conflict began to wrack Missouri. Gangs of Confederate insurgents, commonly known as "bushwhackers", ambushed and battled Union troops and Unionist state militia forces. Much of the fighting was between Missourians of different persuasions; both sides carried out large-scale atrocities against civilians, ranging from forced resettlement to murder. Historians estimate that the population of the state fell by one-third during the war; most survived but fled or were driven out by one side or the other. Many of the most brutal bushwhacker leaders, such as William C. Quantrill and William T. "Bloody Bill" Anderson, won national notoriety. A group of their followers remained under arms and carried out robberies and murders for sixteen years after the war, under the leadership of Jesse James, his brother Frank James, and Cole Younger and his brothers.
By most measures, the Confederate guerrilla insurgency in Missouri during the Civil War was the worst such conflict ever to occur on American soil. By one calculation, nearly twenty-seven thousand Missourians died in the violence. Historians have offered various explanations for the anomalously high level of guerrilla activity in Missouri, including the possibility that the violence was linked to thousands of court-ordered sales of property belonging to the state’s Confederate sympathizers, beginning in 1862 and continuing throughout the war. The property sales arose from court judgments for defaulted debts incurred early in the war to arm rebel troops. 
The Union mounted several attempts to capture the trans-Mississippi regions of Texas and Louisiana from 1862 until the war's end. With ports to the east under blockade or captured, Texas in particular became a blockade-running haven. Referred to as the "back door" of the Confederacy, Texas and western Louisiana continued to provide cotton crops that were transferred overland to the Mexican border towns of Matamoros and the port of Bagdad, and shipped to Europe by means of blockade runners in exchange for supplies.
Determined to close this trade, the Union mounted several invasion attempts of Texas, each of them unsuccessful. Confederate victories at Galveston, Texas, the Battle of Sabine Pass and the Second Bayou Teche Campaign repulsed invasion forces. The Union's disastrous Red River Campaign in western Louisiana, including a defeat at the Battle of Mansfield, effectively ended the Union's final invasion attempt of the region until the fall of the Confederacy. Jeffery Prushankin argues that Kirby Smith's "pride, poor judgment, and lack of military skill" prevented General Richard Taylor from potentially winning a victory that could have greatly affected the military and political situation east of the Mississippi River.
Isolated from events in the east, the Civil War continued at a low level in the Trans-Mississippi theater for several months after Lee's surrender in April 1865. The last battle of the war occurred at Palmito Ranch in southern Texas – a Confederate victory.