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General or specialized [[Chaperone_(protein)|chaperones]] [[Solubilization|solubilize]] the ribosomal proteins and facilitate their import into the [[Cell_nucleus|nucleus]]. Assembly of the eukaryotic ribosome appears to be driven by the ribosomal proteins in vivo when assembly is also aided by chaperones. Most ribosomal proteins assemble with rRNA co-transcriptionally, becoming associated more stably as assembly proceeds, and the active sites of both subunits are constructed last.<ref name="pmid24524803">{{cite journal| author=Ban N, Beckmann R, Cate JH, Dinman JD, Dragon F, Ellis SR et al.| title=A new system for naming ribosomal proteins. | journal=Curr Opin Struct Biol | year= 2014 | volume= 24 | issue= | pages= 165-9 | pmid=24524803 | doi=10.1016/j.sbi.2014.01.002 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24524803 }} </ref> |
General or specialized [[Chaperone_(protein)|chaperones]] [[Solubilization|solubilize]] the ribosomal proteins and facilitate their import into the [[Cell_nucleus|nucleus]]. Assembly of the eukaryotic ribosome appears to be driven by the ribosomal proteins in vivo when assembly is also aided by chaperones. Most ribosomal proteins assemble with rRNA co-transcriptionally, becoming associated more stably as assembly proceeds, and the active sites of both subunits are constructed last.<ref name="pmid24524803">{{cite journal| author=Ban N, Beckmann R, Cate JH, Dinman JD, Dragon F, Ellis SR et al.| title=A new system for naming ribosomal proteins. | journal=Curr Opin Struct Biol | year= 2014 | volume= 24 | issue= | pages= 165-9 | pmid=24524803 | doi=10.1016/j.sbi.2014.01.002 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24524803 }} </ref> |
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⚫ | Recent ''''de novo'''' proteomics experiments where the authors characterized ''in vivo'' ribosome-assembly intermediates and associated assembly factors from wild-type ''Escherichia coli'' cells using a general quantitative mass spectrometry (qMS) approach have confirmed the presence of all the known small and large subunit components and have identified a total of 21 known and potentially new ribosome-assembly-factors that co-localise with various ribosomal particles.<ref name="pmid23228329">{{cite journal| author=Chen SS, Williamson JR| title=Characterization of the ribosome biogenesis landscape in E. coli using quantitative mass spectrometry. | journal=J Mol Biol | year= 2013 | volume= 425 | issue= 4 | pages= 767-79 | pmid=23228329 | doi=10.1016/j.jmb.2012.11.040 | pmc=PMC3568210 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23228329 }} </ref> |
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⚫ | |||
==Table of E.coli 50S large subunits== |
==Table of E.coli 50S large subunits== |
Revision as of 13:43, 26 February 2015
Welcome
Hi
I am WeigelaPen and I have started editing pages of protein domains, making links to the Pfam database of protein families/domains.
Please feel free to add more up-to-date annotation for any protein domains if you think the current annotation is old and where more recent work gives better explanation of function.
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Notes
Template for Pfam-box or info-box Template:Infobox protein family
Glucose-6-phosphate dehydrogenase, NAD binding domain | |||||||||
---|---|---|---|---|---|---|---|---|---|
![]() glucose 6-phosphate dehydrogenase from leuconostoc mesenteroides | |||||||||
Identifiers | |||||||||
Symbol | G6PD_N | ||||||||
Pfam | PF00479 | ||||||||
Pfam clan | CL0063 | ||||||||
InterPro | IPR022674 | ||||||||
PROSITE | PDOC00067 | ||||||||
SCOP2 | 1dpg / SCOPe / SUPFAM | ||||||||
|
Template for Table Table cell templates provide a set of templates to configure text and color in cells in a standard way, using phrases such as Yes, No or n/a.
Table
Col 1 | Human gene | C. elegans gene | D. melanogaster gene | S. cerevisiae gene | Sch. pombe gene |
---|---|---|---|---|---|
Ex for col 1, row1 | Ex for col 2 | Ex for col3 | Ex for col4 | Ex for col5 | Ex for col6 |
Ex col1 row 2 a | |||||
CDK8 | CDK8 | cdk-8 | Cdk8 | SSN3 | srb10 |
- a Fungal-specific
- b Protein-name in Sch. pombe
Table of conserved subunits of cytochrome oxidase c complex
No. | Subunit name | Human protein | Protein description from UniProt | Pfam family with Human protein
|
---|---|---|---|---|
1 | Cox1 | COX1_HUMAN | Cytochrome c oxidase subunit 1 | Pfam PF00115 |
2 | Cox2 | COX2_HUMAN | Cytochrome c oxidase subunit 2 | Pfam PF02790, Pfam PF00116 |
3 | Cox3 | COX3_HUMAN | Cytochrome c oxidase subunit 3 | Pfam PF00510 |
4 | Cox4i1 | COX41_HUMAN | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial | Pfam PF02936 |
5 | Cox4a2 | COX42_HUMAN | Cytochrome c oxidase subunit 4 isoform 2, mitochondrial | Pfam PF02936 |
6 | Cox5a | COX5A_HUMAN | Cytochrome c oxidase subunit 5A, mitochondrial | Pfam PF02284 |
7 | Cox5b | COX5B_HUMAN | Cytochrome c oxidase subunit 5B, mitochondrial | Pfam PF01215 |
8 | Cox6a1 | CX6A1_HUMAN | Cytochrome c oxidase subunit 6A1, mitochondrial | Pfam PF02046 |
9 | Cox6a2 | CX6A2_HUMAN | Cytochrome c oxidase subunit 6A2, mitochondrial | Pfam PF02046 |
10 | Cox6b1 | CX6B1_HUMAN | Cytochrome c oxidase subunit 6B1 | Pfam PF02297 |
11 | Cox6b2 | CX6B2_HUMAN | Cytochrome c oxidase subunit 6B2 | Pfam PF02297 |
12 | Cox6c | COX6C_HUMAN | Cytochrome c oxidase subunit 6C | Pfam PF02937 |
13 | Cox7a1 | CX7A1_HUMAN | Cytochrome c oxidase subunit 7A1, mitochondrial | Pfam PF02238 |
14 | Cox7a2 | CX7A2_HUMAN | Cytochrome c oxidase subunit 7A2, mitochondrial | Pfam PF02238 |
15 | Cox7a3 | COX7S_HUMAN | Putative cytochrome c oxidase subunit 7A3, mitochondrial | Pfam PF02238 |
16 | Cox7b | COX7B_HUMAN | Cytochrome c oxidase subunit 7B, mitochondrial | Pfam PF05392 |
17 | Cox7c | COX7C_HUMAN | Cytochrome c oxidase subunit 7C, mitochondrial | Pfam PF02935 |
18 | Cox7r | COX7R_HUMAN | Cytochrome c oxidase subunit 7A-related protein, mitochondrial | Pfam PF02238 |
19 | Cox8a | COX8A_HUMAN | Cytochrome c oxidase subunit 8A, mitochondrial P | Pfam PF02285 |
20 | Cox8c | COX8C_HUMAN | Cytochrome c oxidase subunit 8C, mitochondrial | Pfam PF02285 |
Assembly subunits[1][2][3] | ||||
1 | Coa1 | COA1_HUMAN | Cytochrome c oxidase assembly factor 1 homolog | Pfam PF08695 |
2 | Coa3 | COA3_HUMAN | Cytochrome c oxidase assembly factor 3 homolog, mitochondrial | Pfam PF09813 |
3 | Coa4 | COA4_HUMAN | Cytochrome c oxidase assembly factor 4 homolog, mitochondrial | Pfam PF06747 |
4 | Coa5 | COA5_HUMAN | Cytochrome c oxidase assembly factor 5 | Pfam PF10203 |
5 | Coa6 | COA6_HUMAN | Cytochrome c oxidase assembly factor 6 homolog | Pfam PF02297 |
6 | Coa7 | COA7_HUMAN | Cytochrome c oxidase assembly factor 7, | Pfam PF08238 |
7 | Cox11 | COX11_HUMAN | Cytochrome c oxidase assembly protein COX11 mitochondrial | Pfam PF04442 |
8 | Cox14 | COX14_HUMAN | Cytochrome c oxidase assembly protein | Pfam PF14880 |
9 | Cox15 | COX15_HUMAN | Cytochrome c oxidase assembly protein COX15 homolog | Pfam PF02628 |
10 | Cox16 | COX16_HUMAN | Cytochrome c oxidase assembly protein COX16 homolog mitochondrial | Pfam PF14138 |
11 | Cox17 | COX17_HUMAN | Cytochrome c oxidase copper chaperone | Pfam PF05051 |
12 | Cox18[4] | COX18_HUMAN | Mitochondrial inner membrane protein (Cytochrome c oxidase assembly protein 18) | Pfam PF02096 |
13 | Cox19 | COX19_HUMAN | Cytochrome c oxidase assembly protein | Pfam PF06747 |
14 | Cox20 | COX20_HUMAN | Cytochrome c oxidase protein 20 homolog | Pfam PF12597 |
Table of Subunit composition of Complex III
The bc1 complex, or Complex III, contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1.[5][6]
No. | Subunit name | Human protein | Protein description from UniProt | Pfam family with Human protein |
---|---|---|---|---|
Respiratory subunit proteins | ||||
1 | MT-CYB / Cyt b | CYB_HUMAN | Cytochrome b | PF13631 |
2 | CYC1 / Cyt c1 | CY1_HUMAN | Cytochrome c1, heme protein, mitochondrial | PF02167 |
3 | Rieske / UCR1 | UCRI_HUMAN | Cytochrome b-c1 complex subunit Rieske, mitochondrial EC=1.10.2.2 | PF02921 , PF00355 |
Core protein subunits | ||||
4 | QCR1 / SU1 | QCR1_HUMAN | Cytochrome b-c1 complex subunit 1, mitochondrial | PF00675, PF05193 |
5 | QCR2 / SU2 | QCR2_HUMAN | Cytochrome b-c1 complex subunit 2, mitochondrial | PF00675, PF05193 |
Low-molucular weight protein subunits | ||||
6 | QCR6 / SU6 | QCR6_HUMAN | Cytochrome b-c1 complex subunit 6, mitochondrial | PF02320 |
7 | QCR7 / SU7 | QCR7_HUMAN | Cytochrome b-c1 complex subunit 7 | PF02271 |
8 | QCR8 / SU8 | QCR8_HUMAN | Cytochrome b-c1 complex subunit 8 | PF02939 |
9 | QCR9 / SU9 / UCRC | QCR9_HUMAN | Cytochrome b-c1 complex subunit 9 | PF05365 |
10 | QCR10 / SU10 | QCR10_HUMAN | Cytochrome b-c1 complex subunit 10 | PF08997 |
11 | QCR11 / SU11 a | UCRI_HUMAN | Cytochrome b-c1 complex subunit 11 | PF09165 |
- a A cleavage product of 8 kDa from the N-terminus of Rieske
|-
| 1 || SdhA || SDHA_HUMAN || Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial ||PF00890, PF02910
|-
| 2 || SdhB || SDHB_HUMAN || Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial ||PF13085, PF13183 |-
| 3 || SdhC || C560_HUMAN || Succinate dehydrogenase cytochrome b560 subunit, mitochondrial ||PF01127
|-
| 4 || SdhD || DHSD_HUMAN || Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial ||PF05328
|-
|}
Table of E.coli small Ribosomal subunits
Subunit No. | Subunit name | E.coli protein | Pfam family with E.coli protein |
---|---|---|---|
1 | 30S ribosomal protein S1 | RS1_ECOLI | PF00575 |
2 | 30S ribosomal protein S2 | RS2_ECOLI | PF00318 |
3 | 30S ribosomal protein S3 | RS3_ECOLI | PF00189 ,PF07650 |
4 | 30S ribosomal protein S4 | RS4_ECOLI | PF00163 ,PF01479 |
5 | 30S ribosomal protein S5 | RS5_ECOLI | PF00333 ,PF03719 |
6 | 30S ribosomal protein S6 | RS6_ECOLI | PF01250 |
7 | 30S ribosomal protein S7 | RS7_ECOLI | PF00177 |
8 | 30S ribosomal protein S8 | RS8_ECOLI | PF00410 |
9 | 30S ribosomal protein S9 | RS9_ECOLI | PF00380 |
10 | 30S ribosomal protein S10 | RS10_ECOLI | PF00338 |
11 | 30S ribosomal protein S11 | RS11_ECOLI | PF00411 |
12 | 30S ribosomal protein S12 | RS12_ECOLI | PF00164 |
13 | 30S ribosomal protein S13 | RS13_ECOLI | PF00416 |
14 | 30S ribosomal protein S14 | RS14_ECOLI | PF00253 |
15 | 30S ribosomal protein S15 | RS15_ECOLI | PF00312 |
16 | 30S ribosomal protein S16 | RS16_ECOLI | PF00886 |
27 | 30S ribosomal protein S17 | RS17_ECOLI | PF00366 |
28 | 30S ribosomal protein S18 | RS18_ECOLI | PF01084 |
29 | 30S ribosomal protein S19 | RS19_ECOLI | PF00203 |
20 | 30S ribosomal protein S20 | RS20_ECOLI | PF01649 |
21 | 30S ribosomal protein S21 | RS21_ECOLI | PF01165 |
Table of Human small Ribosomal subunits
Subunit No. | Subunit name | Human protein | Pfam family with Human protein | Pfam family description
|
---|---|---|---|---|
2 | ribosomal protein S2 | RS2_HUMAN | PF03719 | Ribosomal protein S5, C-terminal domain |
2 | ribosomal protein S2 | RS2_HUMAN | PF00333 | Ribosomal protein S5, N-terminal domain |
3 | ribosomal protein S3 | RS3_HUMAN | PF00189 | Ribosomal protein S3, C-terminal domain |
3a | ribosomal protein S3a | RS3A_HUMAN | PF01015 | Ribosomal S3Ae family |
4 | ribosomal protein S4, X isoform | RS4X_HUMAN | PF08071 | RS4NT (NUC023) domain |
4 | ribosomal protein S4, X isoform | RS4X_HUMAN | PF01479 | S4 domain |
4 | ribosomal protein S4, X isoform | RS4X_HUMAN | PF00900 | Ribosomal family S4e |
4 | ribosomal protein S4, X isoform | RS4X_HUMAN | PF16121 | 40S ribosomal protein S4 C-terminus |
4 | ribosomal protein S4, Y isoform 1 | RS4Y1_HUMAN | PF08071 | RS4NT (NUC023) domain |
4 | ribosomal protein S4, Y isoform 1 | RS4Y1_HUMAN | PF00900 | Ribosomal family S4e |
4 | ribosomal protein S4, Y isoform 1 | RS4Y1_HUMAN | PF16121 | 40S ribosomal protein S4 C-terminus |
4 | ribosomal protein S4, Y isoform 2 | RS4Y2_HUMAN | PF08071 | RS4NT (NUC023) domain |
4 | ribosomal protein S4, Y isoform 2 | RS4Y2_HUMAN | PF00900 | Ribosomal family S4e |
4 | ribosomal protein S4, Y isoform 2 | RS4Y2_HUMAN | PF16121 | 40S ribosomal protein S4 C-terminus |
5 | ribosomal protein S5 | RS5_HUMAN | PF00177 | Ribosomal protein S7p/S5e |
6 | ribosomal protein S6 | RS6_HUMAN | PF01092 | Ribosomal protein S6e |
7 | ribosomal protein S7 | RS7_HUMAN | PF01251 | Ribosomal protein S7e |
8 | ribosomal protein S8 | RS8_HUMAN | PF01201 | Ribosomal protein S8e |
9 | ribosomal protein S9 | RS9_HUMAN | PF01479 | S4 domain |
9 | ribosomal protein S9 | RS9_HUMAN | PF00163 | Ribosomal protein S4/S9 N-terminal domain |
10 | ribosomal protein S10 | RS10_HUMAN | PF03501 | Plectin/S10 domain |
11 | ribosomal protein S11 | RS11_HUMAN | PF16205 | Ribosomal_S17 N-terminal |
11 | ribosomal protein S11 | RS11_HUMAN | PF00366 | Ribosomal protein S17 |
12 | ribosomal protein S12 | RS12_HUMAN | PF01248 | Ribosomal protein L7Ae/L30e/S12e/Gadd45 family |
13 | ribosomal protein S13 | RS13_HUMAN | PF08069 | Ribosomal S13/S15 N-terminal domain |
13 | ribosomal protein S13 | RS13_HUMAN | PF00312 | Ribosomal protein S15 |
14 | ribosomal protein S14 | RS14_HUMAN | PF00411 | Ribosomal protein S11 |
15 | ribosomal protein S15 | RS15_HUMAN | PF00203 | Ribosomal protein S19 |
15a | ribosomal protein S15a | RS15A_HUMAN | PF00410 | Ribosomal protein S8 |
16 | ribosomal protein S16 | RS16_HUMAN | PF00380 | Ribosomal protein S9/S16 |
17 | ribosomal protein S17 | RS17_HUMAN | PF00833 | Ribosomal S17 |
18 | ribosomal protein S18 | RS18_HUMAN | PF00416 | Ribosomal protein S13/S18 |
19 | ribosomal protein S19 | RS19_HUMAN | PF01090 | Ribosomal protein S19e |
20 | ribosomal protein S20 | RS20_HUMAN | PF00338 | Ribosomal protein S10p/S20e |
21 | ribosomal protein S21 | RS21_HUMAN | PF01249 | Ribosomal protein S21e |
23 | ribosomal protein S23 | RS23_HUMAN | PF00164 | Ribosomal protein S12/S23 |
24 | ribosomal protein S24 | RS24_HUMAN | PF01282 | Ribosomal protein S24e |
25 | ribosomal protein S25 | RS25_HUMAN | PF03297 | S25 ribosomal protein |
26 | ribosomal protein S26 | RS26_HUMAN | PF01283 | Ribosomal protein S26e |
27 | ribosomal protein S27 | RS27_HUMAN | PF01667 | Ribosomal protein S27 |
28 | ribosomal protein S28 | RS28_HUMAN | PF01200 | Ribosomal protein S28e |
29 | ribosomal protein S29 | RS29_HUMAN | PF00253 | Ribosomal protein S14p/S29e |
30 | ribosomal protein S30 | RS30_HUMAN | PF04758 | Ribosomal protein S30 |
A | ribosomal protein SA | RSSA_HUMAN | PF16122 | 40S ribosomal protein SA C-terminus |
A | ribosomal protein SA | RSSA_HUMAN | PF00318 | Ribosomal protein S2 |
Assembly of the ribosome in eukaryotes
Ribosomes, which synthesize the proteome of cells, are complex ribonucleoproteins that, in eukaryotes, contain 79–80 proteins and four ribosomal RNAs(rRNAs). General or specialized chaperones solubilize the ribosomal proteins and facilitate their import into the nucleus. Assembly of the eukaryotic ribosome appears to be driven by the ribosomal proteins in vivo when assembly is also aided by chaperones. Most ribosomal proteins assemble with rRNA co-transcriptionally, becoming associated more stably as assembly proceeds, and the active sites of both subunits are constructed last.[7]
Recent 'de novo' proteomics experiments where the authors characterized in vivo ribosome-assembly intermediates and associated assembly factors from wild-type Escherichia coli cells using a general quantitative mass spectrometry (qMS) approach have confirmed the presence of all the known small and large subunit components and have identified a total of 21 known and potentially new ribosome-assembly-factors that co-localise with various ribosomal particles.[8]
Table of E.coli 50S large subunits
|- | 1 || 50S ribosomal protein L1 || RL1_ ECOLI || PF00687 Ribosomal protein L1p/L10e family |-
| 2 || 50S ribosomal protein L2 || RL2_ ECOLI || PF03947 Ribosomal Proteins L2, C-terminal domain |-
| 2 || 50S ribosomal protein L2 || RL2_ ECOLI || PF00181 Ribosomal Proteins L2, RNA binding domain |-
| 3 || 50S ribosomal protein L3 || RL3_ ECOLI || PF00297 Ribosomal protein L3 |-
| 4 || 50S ribosomal protein L4 || RL4_ ECOLI || PF00573 Ribosomal protein L4/L1 family |-
| 5 || 50S ribosomal protein L5 || RL5_ ECOLI || PF00281 Ribosomal protein L5 |-
| 5 || 50S ribosomal protein L5 || RL5_ ECOLI || PF00673 ribosomal L5P family C-terminus |-
| 6 || 50S ribosomal protein L6 || RL6_ ECOLI || PF00347 Ribosomal protein L6 |-
| 7/12 || 50S ribosomal protein L7/L12 || RL7_ ECOLI || PF16320 Ribosomal protein L7/L12 dimerisation domain |-
| 8 || 50S ribosomal protein L7/L12 || RL7_ ECOLI || PF00542 Ribosomal protein L7/L12 C-terminal domain |-
| 9 || 50S ribosomal protein L9 || RL9_ ECOLI || PF03948 Ribosomal protein L9, C-terminal domain |-
| 9 || 50S ribosomal protein L9 || RL9_ ECOLI || PF01281 Ribosomal protein L9, N-terminal domain |-
| 10 || 50S ribosomal protein L10 || RL10_ ECOLI || PF00466 Ribosomal protein L10 |-
| 11 || 50S ribosomal protein L11 || RL11_ ECOLI || PF03946 Ribosomal protein L11, N-terminal domain |-
| 11 || 50S ribosomal protein L11 || RL11_ ECOLI || PF00298 Ribosomal protein L11, RNA binding domain |-
| 13 || 50S ribosomal protein L13 || RL13_ ECOLI || PF00572 Ribosomal protein L13 |-
| 14 || 50S ribosomal protein L14 || RL14_ ECOLI || PF00238 Ribosomal protein L14p/L23e |-
| 15 || 50S ribosomal protein L15 || RL15_ ECOLI || PF00828 Ribosomal protein L18e/L15 |-
| 16 || 50S ribosomal protein L16 || RL16_ ECOLI || PF00252 Ribosomal protein L16p/L10e |-
| 17 || 50S ribosomal protein L17 || RL17_ ECOLI || PF01196 Ribosomal protein L17 |-
| 18 || 50S ribosomal protein L18 || RL18_ ECOLI || PF00861 Ribosomal L18p/L5e family |-
| 19 || 50S ribosomal protein L19 || RL19_ ECOLI || PF01245 Ribosomal protein L19 |-
| 20 || 50S ribosomal protein L20 || RL20_ ECOLI || PF00453 Ribosomal protein L20 |-
| 21 || 50S ribosomal protein L21 || RL21_ ECOLI || PF00829 Ribosomal prokaryotic L21 protein |-
| 22 || 50S ribosomal protein L22 || RL22_ ECOLI || PF00237 Ribosomal protein L22p/L17e |-
| 23 || 50S ribosomal protein L23 || RL23_ ECOLI || PF00276 Ribosomal protein L23 |-
| 24 || 50S ribosomal protein L24 || RL24_ ECOLI || PF00467 KOW motif |-
| 25 || 50S ribosomal protein L25 || RL25_ ECOLI || PF01386 Ribosomal L25p family |-
| 27 || 50S ribosomal protein L27 || RL27_ ECOLI || PF01016 Ribosomal L27 protein |-
| 28 || 50S ribosomal protein L28 || RL28_ ECOLI || PF00830 Ribosomal L28 family |-
| 29 || 50S ribosomal protein L29 || RL29_ ECOLI || PF00831 Ribosomal L29 protein |-
| 30 || 50S ribosomal protein L30 || RL30_ ECOLI || PF00327 Ribosomal protein L30p/L7e |-
| 31 || 50S ribosomal protein L31 || RL31_ ECOLI || PF01197 Ribosomal protein L31 |-
| 31B || 50S ribosomal protein L31 type B || RL31B_ ECOLI || PF01197 Ribosomal protein L31 |-
| 32 || 50S ribosomal protein L32 || RL32_ ECOLI || PF01783 Ribosomal L32p protein family |-
| 33 || 50S ribosomal protein L33 || RL33_ ECOLI || PF00471 Ribosomal protein L33 |-
| 34 || 50S ribosomal protein L34 || RL34_ ECOLI || PF00468 Ribosomal protein L34 |-
| 35 || 50S ribosomal protein L35 || RL35_ ECOLI || PF01632 Ribosomal protein L35 |-
| 36 || 50S ribosomal protein L36 || RL36_ ECOLI || PF00444 Ribosomal protein L36 |-
|}
infoboxes lost to ComplexI
NADH-Ubiquinone/plastoquinone (complex I), various chains | |||||||||
---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||
Symbol | Oxidored_q1 | ||||||||
Pfam | PF00361 | ||||||||
Pfam clan | CL0425 | ||||||||
InterPro | IPR001750 | ||||||||
TCDB | 3.D.9 | ||||||||
OPM superfamily | 279 | ||||||||
OPM protein | 3rko | ||||||||
|
NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus | |||||||||
---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||
Symbol | Oxidored_q1_C | ||||||||
Pfam | PF01010 | ||||||||
InterPro | IPR002128 | ||||||||
|
NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus | |||||||||
---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||
Symbol | Oxidored_q1_N | ||||||||
Pfam | PF00662 | ||||||||
InterPro | IPR001516 | ||||||||
|
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L | |||||||||
---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||
Symbol | Oxidored_q2 | ||||||||
Pfam | PF00420 | ||||||||
InterPro | IPR001133 | ||||||||
|
NADH-ubiquinone/plastoquinone oxidoreductase chain 6 | |||||||||
---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||
Symbol | Oxidored_q3 | ||||||||
Pfam | PF00499 | ||||||||
InterPro | IPR001457 | ||||||||
|
NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 | |||||||||
---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||
Symbol | Oxidored_q4 | ||||||||
Pfam | PF00507 | ||||||||
InterPro | IPR000440 | ||||||||
|
NADH-ubiquinone oxidoreductase chain 4, amino terminus | |||||||||
---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||
Symbol | Oxidored_q5_N | ||||||||
Pfam | PF01059 | ||||||||
InterPro | IPR000260 | ||||||||
|
NADH ubiquinone oxidoreductase, 20 Kd subunit | |||||||||
---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||
Symbol | Oxidored_q6 | ||||||||
Pfam | PF01058 | ||||||||
InterPro | IPR006137 | ||||||||
PROSITE | PDOC00858 | ||||||||
|
Reference management
- [ Help:Userspace_draft Help:Userspace_draft]
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No. | Human/Bovine subunit | Human protein | Protein description (UniProt) | Pfam family with Human protein |
---|---|---|---|---|
Core Subunitsa | ||||
1 | NDUFS7 / PSST / NUKM | NDUS7_HUMAN | NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial EC=1.6.5.3 EC=1.6.99.3 | PF01058 |
2 | NDUFS8 / TYKY / NUIM | NDUS8_HUMAN | NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial EC=1.6.5.3 EC=1.6.99.3 | PF12838 |
3 | NDUFV2 / 24kD / NUHM | NDUV2_HUMAN | NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial EC=1.6.5.3 EC=1.6.99.3 | PF01257 |
4 | NDUFS3 / 30kD / NUGM | NDUS3_HUMAN | NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial EC=1.6.5.3 EC=1.6.99.3 | PF00329 |
5 | NDUFS2 / 49kD / NUCM | NDUS2_HUMAN | NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial EC=1.6.5.3 EC=1.6.99.3 | PF00346 |
6 | NDUFV1 / 51kD / NUBM | NDUV1_HUMAN | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial EC=1.6.5.3 EC=1.6.99.3 | PF01512 |
7 | NDUFS1 / 75kD / NUAM | NDUS1_HUMAN | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial EC=1.6.5.3 EC=1.6.99.3 | PF00384 |
8 | ND1 / NU1M | NU1M_HUMAN | NADH-ubiquinone oxidoreductase chain 1 EC=1.6.5.3 | PF00146 |
9 | ND2 / NU2M | NU2M_HUMAN | NADH-ubiquinone oxidoreductase chain 2 EC=1.6.5.3 | PF00361, PF06444 |
10 | ND3 / NU3M | NU3M_HUMAN | NADH-ubiquinone oxidoreductase chain 3 EC=1.6.5.3 | PF00507 |
11 | ND4 / NU4M | NU4M_HUMAN | NADH-ubiquinone oxidoreductase chain 4 EC=1.6.5.3 | PF01059,PF00361 |
12 | ND4L / NULM | NU4LM_HUMAN | NADH-ubiquinone oxidoreductase chain 4L EC=1.6.5.3 | PF00420 |
13 | ND5 / NU5M | NU5M_HUMAN | NADH-ubiquinone oxidoreductase chain 5 EC=1.6.5.3 | PF00361 |
14 | ND6 / NU6M | NU6M_HUMAN | NADH-ubiquinone oxidoreductase chain 6 EC=1.6.5.3 | PF00499 |
Core accessory subunitsb | ||||
15 | NDUFS6 / 13A | NDUS6_HUMAN | NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial | PF10276 |
16 | NDUFA12 / B17.2 | NDUAC_HUMAN | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 | PF05071 |
17 | NDUFS4 / AQDQ | NDUS4_HUMAN | NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial | PF04800 |
18 | NDUFA9 / 39kDa | NDUA9_HUMAN | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial | PF01370 |
19 | NDUFAB1 / ACPM | ACPM_HUMAN | Acyl carrier protein, mitochondrial | PF00550 |
20 | NDUFA2 / B8 | NDUA2_HUMAN | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 | PF05047 |
21 | NDUFA1 / MFWE | NDUA1_HUMAN | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | PF15879 |
22 | NDUFB3 / B12 | NDUB3_HUMAN | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 | PF08122 |
23 | NDUFA5 / AB13 | NDUA5_HUMAN | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 | - |
24 | NDUFA6 / B14 | NDUA6_HUMAN | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 | PF05347 |
25 | NDUFA11 / B14.7 | NDUAB_HUMAN | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 | PF02466 |
26 | NDUFB11 / ESSS | NDUBB_HUMAN | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial | PF10183 |
27 | NDUFS5 / PFFD | NDUS5_HUMAN | NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 | PF10200 |
28 | NDUFB4 / B15 | NDUB4_HUMAN | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 | PF07225 |
29 | NDUFA13 /A13 | NDUAD_HUMAN | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 | PF06212 |
30 | NDUFB7 / B18 | NDUB7_HUMAN | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 | PF05676 |
31 | NDUFA8 / PGIV | NDUA8_HUMAN | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 | PF06747 |
32 | NDUFB9 / B22 | NDUB9_HUMAN | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 | PF05347 |
33 | NDUFB10 / PDSW | NDUBA_HUMAN | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 | PF10249 |
34 | NDUFB8 / ASHI | NDUB8_HUMAN | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial | PF05821 |
35 | NDUFC2 / B14.5B | NDUC2_HUMAN | NADH dehydrogenase [ubiquinone] 1 subunit C2 | PF06374 |
36 | NDUFB2 / AGGG | NDUB2_HUMAN | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial | PF14813 |
37 | NDUFA7 / B14.5A | NDUA7_HUMAN | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 | PF07347 |
38 | NDUFA3 / B9 | NDUA3_HUMAN | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 | PF14987 |
39 | NDUFA4 / MLRQ | NDUA4_HUMAN | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 | PF06522 |
40 | NDUFB5 / SGDH | NDUB5_HUMAN | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial | PF09781 |
41 | NDUFB1 / MNLL | NDUB1_HUMAN | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 | PF08040 |
42 | NDUFC1 / KFYI | NDUC1_HUMAN | NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial | PF15088 |
43 | NDUFA10 / 42kD | NDUAA_HUMAN | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial | PF01712 |
44 | NDUFA4L2 | NUA4L_HUMAN | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 | PF15880 |
45 | NDUFV3 | NDUV3_HUMAN | NADH dehydrogenase [ubiquinone] flavoprotein 3, 10kDa | - |
46 | NDUFB6 | NDUB6_HUMAN | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 | PF09782 |
Assembly factor proteins[11] | ||||
47 | NDUFAF1 | CIA30_HUMAN | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex, assembly factor 1 | PF08547 |
48 | NDUFAF2 | MIMIT_HUMAN | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex, assembly factor 2 | PF05071 |
49 | NDUFAF3 | NDUF3_HUMAN | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 | PF05071 |
50 | NDUFAF4 | NDUF4_HUMAN | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex, assembly factor 4 | PF06784 |
- a Found in all species
- b May or may not be present in any species
Pages under construction
- User:WeigelaPen/Sandpit
Cyclin | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
![]() Structure of the Pho85-Pho80 CDK-cyclin Complex of the Phosphate-responsive Signal
Transduction Pathway *************needs reference | |||||||||||
Identifiers | |||||||||||
Symbol | ? | ||||||||||
Pfam | PF08613 | ||||||||||
Pfam clan | CL0065 | ||||||||||
InterPro | IPR013922 | ||||||||||
PROSITE | PDOC00264 | ||||||||||
SCOP2 | 47954 / SCOPe / SUPFAM | ||||||||||
|
For Article on WINE, to add:See also
External links |
- ^ Szklarczyk R, Wanschers BF, Cuypers TD, Esseling JJ, Riemersma M, van den Brand MA; et al. (2012). "Iterative orthology prediction uncovers new mitochondrial proteins and identifies C12orf62 as the human ortholog of COX14, a protein involved in the assembly of cytochrome c oxidase". Genome Biol. 13 (2): R12. doi:10.1186/gb-2012-13-2-r12. PMC 3334569. PMID 22356826.
{{cite journal}}
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(help)CS1 maint: PMC format (link) CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - ^ Mick DU, Dennerlein S, Wiese H, Reinhold R, Pacheu-Grau D, Lorenzi I; et al. (2012). "MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation". Cell. 151 (7): 1528–41. doi:10.1016/j.cell.2012.11.053. PMID 23260140.
{{cite journal}}
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(help)CS1 maint: multiple names: authors list (link) - ^ Kozjak-Pavlovic V, Prell F, Thiede B, Götz M, Wosiek D, Ott C; et al. (2014). "C1orf163/RESA1 is a novel mitochondrial intermembrane space protein connected to respiratory chain assembly". J Mol Biol. 426 (4): 908–20. doi:10.1016/j.jmb.2013.12.001. PMID 24333015.
{{cite journal}}
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(help)CS1 maint: multiple names: authors list (link) - ^ Gaisne M, Bonnefoy N (2006). "The COX18 gene, involved in mitochondrial biogenesis, is functionally conserved and tightly regulated in humans and fission yeast". FEMS Yeast Res. 6 (6): 869–82. doi:10.1111/j.1567-1364.2006.00083.x. PMID 16911509.
- ^ Zhang Z, Huang L, Shulmeister VM, Chi YI, Kim KK, Hung LW; et al. (1998). "Electron transfer by domain movement in cytochrome bc1". Nature. 392 (6677): 677–84. doi:10.1038/33612. PMID 9565029.
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(help)CS1 maint: multiple names: authors list (link) - ^ Hao GF, Wang F, Li H, Zhu XL, Yang WC, Huang LS; et al. (2012). "Computational discovery of picomolar Q(o) site inhibitors of cytochrome bc1 complex". J Am Chem Soc. 134 (27): 11168–76. doi:10.1021/ja3001908. PMID 22690928.
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(help)CS1 maint: multiple names: authors list (link) - ^ Ban N, Beckmann R, Cate JH, Dinman JD, Dragon F, Ellis SR; et al. (2014). "A new system for naming ribosomal proteins". Curr Opin Struct Biol. 24: 165–9. doi:10.1016/j.sbi.2014.01.002. PMID 24524803.
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(help)CS1 maint: multiple names: authors list (link) - ^ Chen SS, Williamson JR (2013). "Characterization of the ribosome biogenesis landscape in E. coli using quantitative mass spectrometry". J Mol Biol. 425 (4): 767–79. doi:10.1016/j.jmb.2012.11.040. PMC 3568210. PMID 23228329.
{{cite journal}}
: CS1 maint: PMC format (link) - ^ Cardol P (2011). "Mitochondrial NADH:ubiquinone oxidoreductase (complex I) in eukaryotes: a highly conserved subunit composition highlighted by mining of protein databases". Biochim Biophys Acta. 1807 (11): 1390–7. doi:10.1016/j.bbabio.2011.06.015. PMID 21749854.
- ^ Vogel RO, Dieteren CE, van den Heuvel LP, Willems PH, Smeitink JA, Koopman WJ; et al. (2007). "Identification of mitochondrial complex I assembly intermediates by tracing tagged NDUFS3 demonstrates the entry point of mitochondrial subunits". J Biol Chem. 282 (10): 7582–90. doi:10.1074/jbc.M609410200. PMID 17209039.
{{cite journal}}
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(help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - ^ Ogilvie I, Kennaway NG, Shoubridge EA (2005). "A molecular chaperone for mitochondrial complex I assembly is mutated in a progressive encephalopathy". J Clin Invest. 115 (10): 2784–92. doi:10.1172/JCI26020. PMC 1236688. PMID 16200211.
{{cite journal}}
: CS1 maint: PMC format (link) CS1 maint: multiple names: authors list (link) - ^ Dunning CJ, McKenzie M, Sugiana C, Lazarou M, Silke J, Connelly A; et al. (2007). "Human CIA30 is involved in the early assembly of mitochondrial complex I and mutations in its gene cause disease". EMBO J. 26 (13): 3227–37. doi:10.1038/sj.emboj.7601748. PMC 1914096. PMID 17557076.
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(help)CS1 maint: PMC format (link) CS1 maint: multiple names: authors list (link) - ^ Saada A, Vogel RO, Hoefs SJ, van den Brand MA, Wessels HJ, Willems PH; et al. (2009). "Mutations in NDUFAF3 (C3ORF60), encoding an NDUFAF4 (C6ORF66)-interacting complex I assembly protein, cause fatal neonatal mitochondrial disease". Am J Hum Genet. 84 (6): 718–27. doi:10.1016/j.ajhg.2009.04.020. PMC 2694978. PMID 19463981.
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(help)CS1 maint: PMC format (link) CS1 maint: multiple names: authors list (link) - ^ Brown NR, Noble (1995). "The crystal structure of cyclin A". Structure. 3 (11): 1235–47. PMID 8591034.
{{cite journal}}
: Text "10.1016/S0969-2126(01)00259-3" ignored (help); Text "ME, Endicott JA, et al." ignored (help)