40S ribosomal protein S8

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Available structures
PDB Ortholog search: PDBe RCSB
Aliases RPS8, S8, ribosomal protein S8
External IDs MGI: 98166 HomoloGene: 133143 GeneCards: RPS8
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) n/a Chr : 117.15 – 117.16 Mb
PubMed search [2] [3]
View/Edit Human View/Edit Mouse

40S ribosomal protein S8 is a protein that in humans is encoded by the RPS8 gene.[4][5]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S8E family of ribosomal proteins. It is located in the cytoplasm. Increased expression of this gene in colorectal tumors and colon polyps compared to matched normal colonic mucosa has been observed. This gene is co-transcribed with the small nucleolar RNA genes U38A, U38B, U39, and U40, which are located in its fourth, fifth, first, and second introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[5]


  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047675 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Davies B, Fried M (Mar 1993). "The structure of the human intron-containing S8 ribosomal protein gene and determination of its chromosomal location at 1p32-p34.1". Genomics. 15 (1): 68–75. PMID 8432552. doi:10.1006/geno.1993.1011. 
  5. ^ a b "Entrez Gene: RPS8 ribosomal protein S8". 

Further reading[edit]