Ribosomal protein s6

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ribosomal protein S6
Symbol RPS6
Entrez 6194
HUGO 10429
OMIM 180460
RefSeq NM_001010
UniProt P62753
Other data
Locus Chr. 9 p21

Ribosomal protein S6 (rpS6) is a component of the 40S ribosomal subunit and is therefore thought to be involved in regulating translation. While the true function of rpS6 is currently under investigation, studies have shown that it is involved in the regulation of cell size, cell proliferation, and glucose homeostasis.[1]

Studies show that the p70 ribosomal protein S6 kinases (S6K1 and S6K2) and p90 ribosomal protein S6 kinases (RSK) both phosphorylate rpS6 and that S6K1 and S6K2 predominate this function.


  1. ^ Magnuson B1, Ekim B, Fingar DC (2012). "Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks". Biochemical Journal. 441 (1): 1–21. doi:10.1042/BJ20110892. PMID 22168436. 

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