40S ribosomal protein S2

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Available structures
PDBOrtholog search: PDBe RCSB
AliasesRPS2, LLREP3, S2, ribosomal protein S2
External IDsOMIM: 603624 MGI: 105110 HomoloGene: 37714 GeneCards: RPS2
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for RPS2
Genomic location for RPS2
Band16p13.3Start1,962,058 bp[1]
End1,964,841 bp[1]
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 16: 1.96 – 1.96 MbChr 17: 24.72 – 24.72 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

The RPS2 gene is the gene which, in humans, encodes the 40S ribosomal protein S2.[5][6]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S5P family of ribosomal proteins. It is located in the cytoplasm. This gene shares sequence similarity with mouse LLRep3. It is co-transcribed with the small nucleolar RNA gene U64, which is located in its third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[6]


RPS2 has been shown to interact with PRMT3.[7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000140988 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044533 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
  6. ^ a b "Entrez Gene: RPS2 ribosomal protein S2".
  7. ^ Choi, Seeyoung; Jung Cho-Rok; Kim Jin-Young; Im Dong-Soo (Sep 2008). "PRMT3 inhibits ubiquitination of ribosomal protein S2 and together forms an active enzyme complex". Biochim. Biophys. Acta. 1780 (9): 1062–9. doi:10.1016/j.bbagen.2008.05.010. ISSN 0006-3002. PMID 18573314.

Further reading[edit]