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Ribosomal protein S18
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RPS18 ; D6S218E; HKE3; KE-3; KE3; S18
External IDs OMIM180473 MGI98146 HomoloGene88764 GeneCards: RPS18 Gene
Species Human Mouse
Entrez 6222 20084
Ensembl ENSG00000096150 ENSMUSG00000008668
UniProt P62269 P62270
RefSeq (mRNA) NM_022551 NM_011296
RefSeq (protein) NP_072045 NP_035426
Location (UCSC) Chr 6:
33.27 – 33.28 Mb
Chr 17:
33.95 – 33.96 Mb
PubMed search [1] [2]

40S ribosomal protein S18 is a protein that in humans is encoded by the RPS18 gene.[1][2][3]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S13P family of ribosomal proteins. It is located in the cytoplasm. The gene product of the E. coli ortholog (ribosomal protein S13) is involved in the binding of fMet-tRNA, and thus, in the initiation of translation. This gene is an ortholog of mouse Ke3. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[3]


  1. ^ Chassin D, Bellet D, Koman A (Mar 1993). "The human homolog of ribosomal protein S18". Nucleic Acids Res 21 (3): 745. doi:10.1093/nar/21.3.745. PMC 309181. PMID 8441687. 
  2. ^ Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194. 
  3. ^ a b "Entrez Gene: RPS18 ribosomal protein S18". 

Further reading[edit]