The club was founded in 1990. The club's former name was "ISKI SK" and they were owned by the municipality's water distribution company. ISKI SK competed in the Regional Amateur Football League in the 1990–91 season and were promoted to the TFF Second League. After promotion, the club's name changed to İstanbul Büyüksehir Belediyesi. The club played in the TFF Second League until 1996, but after the 2006–07 season they were promoted to the Süper Lig. Finishing 12th in the 2007–08 season enabled them to remain in the Süper Lig for the 2007–08 season. In the 2009–10 season, the club finished the season in 6th place. In the 2012–13 season, the club finished 16th and relegated to the TFF First League. But it finished in the TFF First League as champions and made an immediate return to the top level in the 2013–14 season. In June 2014, the club's name changed to "İstanbul Başakşehir Futbol Kulübü".[3] On following seasons 2014–15 and 2015–16 the club finished in 4th place. On 25 May 2015, İstanbul Başakşehir Futbol Kulübü signed a sponsorship agreement with "Medipol Eğitim ve Sağlık Grubu" (Medipol Education and Health Group) for four years and the team's name changed to "Medipol Başakşehir Futbol Kulübü".[4]
Before the name change İstanbul Başakşehir were playing their games at Atatürk Olympic Stadium but starting from 2014–15 season they play the games at Başakşehir Fatih Terim Stadium. 26 July 2014 opened officially to public. The venue has a capacity of 17,800 spectators. It is the new home of İstanbul Başakşehir playing in the Süper Lig. The construction of the stadium was completed in about 16 months, and it cost ₺178 million.
Only professional players and/or players with first team numbers are listed.
Note: Flags indicate national team as defined under FIFA eligibility rules. Players may hold more than one non-FIFA nationality.