2-dehydropantoate 2-reductase

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
2-dehydropantoate 2-reductase
EC no.
CAS no.37211-74-8
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a 2-dehydropantoate 2-reductase (EC is an enzyme that catalyzes the chemical reaction

(R)-pantoate + NADP+ 2-dehydropantoate + NADPH + H+

Thus, the two substrates of this enzyme are (R)-pantoate and NADP+, whereas its 3 products are 2-dehydropantoate, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-pantoate:NADP+ 2-oxidoreductase. Other names in common use include 2-oxopantoate reductase, 2-ketopantoate reductase, 2-ketopantoic acid reductase, ketopantoate reductase, and ketopantoic acid reductase. This enzyme participates in pantothenate and coa biosynthesis.

Structural studies[edit]

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1KS9, 1YJQ, 1YON, 2EW2, and 2OFP.


  • King HL Jr, Dyar RE, Wilken DR (Aug 10, 1974). "Ketopantoyl lactone and ketopantoic acid reductases: Characterization of the reactions and purification of two forms of ketopantoyl lactone reductase". J. Biol. Chem. 249 (15): 4689–4695. PMID 4603075.